gene
stringlengths 2
16
| uniprot_id
stringlengths 6
10
⌀ | protein_name
stringlengths 0
112
⌀ | protein_function
stringlengths 0
12.5k
⌀ | protein_domains
listlengths 0
285
| protein_interactions
listlengths 0
499
| go_terms
listlengths 0
230
| pathways
listlengths 1
1.11k
|
|---|---|---|---|---|---|---|---|
A1BG
|
P04217
|
Alpha-1B-glycoprotein
|
[
"Ig-like V-type 1",
"Ig-like V-type 2",
"Ig-like V-type 3",
"Ig-like V-type 4",
"Ig-like V-type 5"
] |
[] |
[
"C:blood microparticle",
"C:extracellular exosome",
"C:extracellular region",
"C:extracellular space",
"C:ficolin-1-rich granule lumen",
"C:plasma membrane",
"C:platelet alpha granule lumen",
"C:secretory granule lumen",
"P:immune response-regulating signaling pathway"
] |
[
"GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_IMMUNE_RESPONSE",
"GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOCC_BLOOD_MICROPARTICLE",
"GOCC_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX",
"GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE",
"GOCC_FICOLIN_1_RICH_GRANULE",
"GOCC_FICOLIN_1_RICH_GRANULE_LUMEN",
"GOCC_PLATELET_ALPHA_GRANULE",
"GOCC_PLATELET_ALPHA_GRANULE_LUMEN",
"GOCC_SECRETORY_GRANULE",
"GOCC_SECRETORY_VESICLE",
"GOCC_VESICLE_LUMEN",
"REACTOME_HEMOSTASIS",
"REACTOME_INNATE_IMMUNE_SYSTEM",
"REACTOME_NEUTROPHIL_DEGRANULATION",
"REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION",
"REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2"
] |
|
A1BG-AS1
| null | null | null |
[] |
[] |
[] |
[
"SRC_UP.V1_UP"
] |
A1CF
|
Q9NQ94
|
APOBEC1 complementation factor
|
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay
|
[
"RRM 1",
"RRM 2",
"RRM 3"
] |
[
"ACTMAP",
"CYSRT1",
"DOK3",
"ECM1",
"EIF4G1",
"FHL2",
"FHL3",
"HSPB2",
"KLHDC7B",
"KRT31",
"KRT34",
"METTL27",
"OIP5",
"PLEKHG4",
"POGZ",
"REL",
"RIMBP3",
"SPMIP6",
"TRAF1",
"CAVIN2"
] |
[
"C:apolipoprotein B mRNA editing enzyme complex",
"C:cytoplasm",
"C:endoplasmic reticulum",
"C:mRNA editing complex",
"C:nucleoplasm",
"C:nucleus",
"F:enzyme-substrate adaptor activity",
"F:mRNA binding",
"F:single-stranded RNA binding",
"P:chromosomal 5-methylcytosine DNA demethylation pathway",
"P:cytidine to uridine editing",
"P:embryo implantation",
"P:mRNA localization resulting in post-transcriptional regulation of gene expression",
"P:mRNA modification",
"P:mRNA processing",
"P:negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay",
"P:protein stabilization"
] |
[
"GOBP_BASE_CONVERSION_OR_SUBSTITUTION_EDITING",
"GOBP_CHROMOSOMAL_5_METHYLCYTOSINE_DNA_DEMETHYLATION_PATHWAY",
"GOBP_CYTIDINE_TO_URIDINE_EDITING",
"GOBP_DNA_METABOLIC_PROCESS",
"GOBP_EMBRYO_IMPLANTATION",
"GOBP_INTRACELLULAR_MRNA_LOCALIZATION",
"GOBP_MACROMOLECULE_CATABOLIC_PROCESS",
"GOBP_MRNA_CATABOLIC_PROCESS",
"GOBP_MRNA_METABOLIC_PROCESS",
"GOBP_MRNA_MODIFICATION",
"GOBP_MRNA_PROCESSING",
"GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION",
"GOBP_NEGATIVE_REGULATION_OF_MRNA_CATABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY",
"GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_RNA_CATABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_RNA_METABOLIC_PROCESS",
"GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS",
"GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY",
"GOBP_NUCLEIC_ACID_CATABOLIC_PROCESS",
"GOBP_NUCLEOBASE_CONTAINING_COMPOUND_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_GENE_EXPRESSION",
"GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION",
"GOBP_PROTEIN_STABILIZATION",
"GOBP_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_MRNA_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY",
"GOBP_REGULATION_OF_PROTEIN_STABILITY",
"GOBP_REPRODUCTIVE_PROCESS",
"GOBP_RNA_LOCALIZATION",
"GOBP_RNA_MODIFICATION",
"GOBP_RNA_PROCESSING",
"GOCC_APOLIPOPROTEIN_B_MRNA_EDITING_ENZYME_COMPLEX",
"GOCC_CATALYTIC_COMPLEX",
"GOCC_MRNA_EDITING_COMPLEX",
"GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX",
"GOMF_DOUBLE_STRANDED_RNA_BINDING",
"GOMF_ENZYME_SUBSTRATE_ADAPTOR_ACTIVITY",
"GOMF_MOLECULAR_ADAPTOR_ACTIVITY",
"GOMF_MRNA_BINDING",
"GOMF_SINGLE_STRANDED_RNA_BINDING",
"IL21_UP.V1_DN",
"IL2_UP.V1_DN",
"REACTOME_METABOLISM_OF_RNA",
"REACTOME_MRNA_EDITING",
"REACTOME_MRNA_EDITING_C_TO_U_CONVERSION"
] |
A2M
|
P01023
|
Alpha-2-macroglobulin
|
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
|
[] |
[
"ABHD17C",
"AP2B1",
"ATP5IF1",
"BRK1",
"CLEC2B",
"COPS3",
"CSF2",
"CTNNB1",
"CYFIP1",
"DAZ3",
"DDX20",
"DNTTIP1",
"ERAL1",
"FOXA2",
"FOXR1",
"FZD4",
"H2AZ1",
"H3C12",
"HOXC4",
"IQSEC1",
"KAT5",
"KAT5",
"KRTAP10-7",
"KRTAP8-1",
"LHX6",
"LNX1",
"LYN",
"MGARP",
"MKL1",
"MNDA",
"MRFAP1",
"OTUB1",
"OTUD7B",
"PARK7",
"PIAS1",
"PIK3R1",
"PRDM1",
"RAB38",
"RNF112",
"RNF183",
"S100B",
"SMN2",
"SPATA12",
"STUB1",
"STX11",
"STX19",
"SYK",
"TEAD1",
"TRIM69",
"TWIST2",
"TXN",
"UTP14A",
"VPS29",
"VPS33A",
"ZNF366",
"Ppif"
] |
[
"C:blood microparticle",
"C:extracellular exosome",
"C:extracellular matrix",
"C:extracellular region",
"C:extracellular space",
"C:platelet alpha granule lumen",
"F:calcium-dependent protein binding",
"F:endopeptidase inhibitor activity",
"F:enzyme binding",
"F:growth factor binding",
"F:interleukin-1 binding",
"F:interleukin-8 binding",
"F:protease binding",
"F:serine-type endopeptidase inhibitor activity",
"F:signaling receptor binding",
"F:tumor necrosis factor binding",
"P:negative regulation of complement activation, lectin pathway",
"P:stem cell differentiation"
] |
[
"ATF2_S_UP.V1_DN",
"BMI1_DN_MEL18_DN.V1_DN",
"CYCLIN_D1_KE_.V1_DN",
"EGFR_UP.V1_UP",
"GOBP_ACTIVATION_OF_IMMUNE_RESPONSE",
"GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS",
"GOBP_COMPLEMENT_ACTIVATION",
"GOBP_COMPLEMENT_ACTIVATION_LECTIN_PATHWAY",
"GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM",
"GOBP_DEFENSE_RESPONSE_TO_SYMBIONT",
"GOBP_HUMORAL_IMMUNE_RESPONSE",
"GOBP_IMMUNE_EFFECTOR_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_COMPLEMENT_ACTIVATION",
"GOBP_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE",
"GOBP_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE",
"GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE",
"GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS",
"GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS",
"GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE",
"GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_COMPLEMENT_ACTIVATION",
"GOBP_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE",
"GOBP_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS",
"GOBP_REGULATION_OF_IMMUNE_RESPONSE",
"GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE",
"GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS",
"GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_REGULATION_OF_RESPONSE_TO_STRESS",
"GOBP_STEM_CELL_DIFFERENTIATION",
"GOCC_BLOOD_MICROPARTICLE",
"GOCC_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX",
"GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE",
"GOCC_PLATELET_ALPHA_GRANULE",
"GOCC_PLATELET_ALPHA_GRANULE_LUMEN",
"GOCC_SECRETORY_GRANULE",
"GOCC_SECRETORY_VESICLE",
"GOCC_VESICLE_LUMEN",
"GOMF_CALCIUM_DEPENDENT_PROTEIN_BINDING",
"GOMF_CHEMOKINE_BINDING",
"GOMF_CYTOKINE_BINDING",
"GOMF_C_X_C_CHEMOKINE_BINDING",
"GOMF_ENDOPEPTIDASE_ACTIVITY",
"GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY",
"GOMF_ENZYME_INHIBITOR_ACTIVITY",
"GOMF_ENZYME_REGULATOR_ACTIVITY",
"GOMF_GROWTH_FACTOR_BINDING",
"GOMF_INTERLEUKIN_1_BINDING",
"GOMF_MOLECULAR_FUNCTION_INHIBITOR_ACTIVITY",
"GOMF_PEPTIDASE_ACTIVITY",
"GOMF_PEPTIDASE_INHIBITOR_ACTIVITY",
"GOMF_PEPTIDASE_REGULATOR_ACTIVITY",
"GOMF_PROTEASE_BINDING",
"GOMF_SERINE_HYDROLASE_ACTIVITY",
"GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY",
"GOMF_SIGNALING_RECEPTOR_BINDING",
"GOMF_TUMOR_NECROSIS_FACTOR_BINDING",
"HALLMARK_COAGULATION",
"HALLMARK_IL6_JAK_STAT3_SIGNALING",
"KEGG_COMPLEMENT_AND_COAGULATION_CASCADES",
"KRAS.300_UP.V1_UP",
"KRAS.50_UP.V1_UP",
"KRAS.600.LUNG.BREAST_UP.V1_UP",
"KRAS.600_UP.V1_UP",
"KRAS.BREAST_UP.V1_UP",
"KRAS.KIDNEY_UP.V1_UP",
"KRAS.LUNG.BREAST_UP.V1_UP",
"MEL18_DN.V1_DN",
"PID_IL6_7_PATHWAY",
"REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX",
"REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION",
"REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE",
"REACTOME_HDL_ASSEMBLY",
"REACTOME_HEMOSTASIS",
"REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION",
"REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY",
"REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE",
"REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION",
"REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"STK33_NOMO_UP"
] |
A2ML1
|
A8K2U0
|
Alpha-2-macroglobulin-like protein 1
|
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases
|
[] |
[] |
[
"C:extracellular exosome",
"C:extracellular space",
"F:peptidase inhibitor activity",
"F:serine-type endopeptidase inhibitor activity",
"P:regulation of endopeptidase activity"
] |
[
"GOBP_PROTEOLYSIS",
"GOBP_REGULATION_OF_CATALYTIC_ACTIVITY",
"GOBP_REGULATION_OF_ENDOPEPTIDASE_ACTIVITY",
"GOBP_REGULATION_OF_HYDROLASE_ACTIVITY",
"GOBP_REGULATION_OF_MOLECULAR_FUNCTION",
"GOBP_REGULATION_OF_PEPTIDASE_ACTIVITY",
"GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_PROTEOLYSIS",
"GOMF_ENDOPEPTIDASE_ACTIVITY",
"GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY",
"GOMF_ENZYME_INHIBITOR_ACTIVITY",
"GOMF_ENZYME_REGULATOR_ACTIVITY",
"GOMF_MOLECULAR_FUNCTION_INHIBITOR_ACTIVITY",
"GOMF_PEPTIDASE_ACTIVITY",
"GOMF_PEPTIDASE_INHIBITOR_ACTIVITY",
"GOMF_PEPTIDASE_REGULATOR_ACTIVITY",
"GOMF_SERINE_HYDROLASE_ACTIVITY",
"GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY"
] |
A3GALT2
|
U3KPV4
|
Alpha-1,3-galactosyltransferase 2
|
Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures
|
[] |
[] |
[
"C:Golgi apparatus",
"C:Golgi cisterna membrane",
"C:vesicle",
"F:glycosyltransferase activity",
"F:metal ion binding",
"F:N-acetyllactosaminide 3-alpha-galactosyltransferase activity",
"P:carbohydrate metabolic process",
"P:glycosphingolipid biosynthetic process"
] |
[
"GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_CARBOHYDRATE_METABOLIC_PROCESS",
"GOBP_GLYCOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCOSPHINGOLIPID_METABOLIC_PROCESS",
"GOBP_GLYCOSYLATION",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_GLYCOSYLATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LIPID_MODIFICATION",
"GOBP_LIPOSACCHARIDE_METABOLIC_PROCESS",
"GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS",
"GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_SPHINGOLIPID_METABOLIC_PROCESS",
"GOCC_GOLGI_APPARATUS",
"GOCC_GOLGI_APPARATUS_SUBCOMPARTMENT",
"GOCC_GOLGI_CISTERNA",
"GOCC_GOLGI_CISTERNA_MEMBRANE",
"GOCC_GOLGI_STACK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOMF_GALACTOSYLTRANSFERASE_ACTIVITY",
"GOMF_GLYCOSYLTRANSFERASE_ACTIVITY",
"GOMF_HEXOSYLTRANSFERASE_ACTIVITY",
"GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY",
"WP_GANGLIO_SPHINGOLIPID_METABOLISM",
"WP_GLYCOSPHINGOLIPID_METABOLISM",
"WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES"
] |
A4GALT
|
Q9NPC4
|
Lactosylceramide 4-alpha-galactosyltransferase
|
Glycosyltransferase involved in biosynthesis of P1, P(k) and the rare NOR antigens of P1PK histo-blood group system (PubMed:10747952, PubMed:10748143, PubMed:22965229, PubMed:26773500, PubMed:29572228, PubMed:33460651). Catalyzes the transfer of galactose from UDP-alpha-D-galactose in an alpha1,4 linkage to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)), also known as P(k) antigen or CD77 (PubMed:10748143, PubMed:10747952, PubMed:26773500, PubMed:29572228, PubMed:22965229). Globoside Gb3Cer/P(k)/CD77 is a root structure in biosynthesis pathway of neutral glycosphingolipids of the globo-series. Broadly expressed in cell membranes of immune cells and other tissues, Gb3Cer/P(k)/CD77 antigen may participate in mechanisms that regulate cell-cell interactions and cell differentiation. In germinal center B cells, Gb3Cer/CD77 interacts with CD19 to drive centroblast-to-centrocyte transition, B cell receptor complex assembly and T follicular helper cell differentiation. In epithelium, Gb3Cer regulates CDH1/E-cadherin-dependent cell-cell adhesion counteracting epithelial-to-mesenchymal transition (By similarity) (PubMed:29572228). Synthesizes P1 glycan epitope (alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-GlcNAc-R) by transferring a galactose moiety to paragloboside nLc4 or to complex-type N-glycans (PubMed:26773500, PubMed:29572228, PubMed:33460651). Generates the rare NOR1 and NOR2 antigens which carry a Gal(alpha1->4)GalNAc terminal moiety and are both derived from Gb4Cer precursor (PubMed:22965229, PubMed:26773500, PubMed:33460651). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143)
|
[] |
[] |
[
"C:Golgi membrane",
"C:membrane",
"F:galactosyltransferase activity",
"F:lactosylceramide 4-alpha-galactosyltransferase activity",
"F:toxic substance binding",
"P:globoside biosynthetic process",
"P:glycosphingolipid biosynthetic process",
"P:plasma membrane organization"
] |
[
"AKT_UP_MTOR_DN.V1_UP",
"E2F1_UP.V1_DN",
"ESC_J1_UP_EARLY.V1_UP",
"GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION",
"GOBP_GLYCOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCOSPHINGOLIPID_METABOLIC_PROCESS",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LIPOSACCHARIDE_METABOLIC_PROCESS",
"GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_PLASMA_MEMBRANE_ORGANIZATION",
"GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_SPHINGOLIPID_METABOLIC_PROCESS",
"GOCC_GOLGI_APPARATUS",
"GOCC_GOLGI_MEMBRANE",
"GOMF_GALACTOSYLTRANSFERASE_ACTIVITY",
"GOMF_GLYCOSYLTRANSFERASE_ACTIVITY",
"GOMF_HEXOSYLTRANSFERASE_ACTIVITY",
"GOMF_TOXIC_SUBSTANCE_BINDING",
"GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY",
"KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES",
"REACTOME_GLYCOSPHINGOLIPID_BIOSYNTHESIS",
"REACTOME_GLYCOSPHINGOLIPID_METABOLISM",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_SPHINGOLIPID_METABOLISM",
"WNT_UP.V1_UP",
"WP_GLYCOSPHINGOLIPID_METABOLISM",
"WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES"
] |
A4GNT
|
Q9UNA3
|
Alpha-1,4-N-acetylglucosaminyltransferase
|
Catalyzes the transfer of N-acetylglucosamine (GlcNAc) residues from UDP-N-acetyl-alpha-D-glucosamine donnors to beta (1->4)-linked or beta-(1->3)-linked galactose residues on O-glycans like core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity)
|
[] |
[] |
[
"C:Golgi membrane",
"C:membrane",
"F:acetylglucosaminyltransferase activity",
"P:carbohydrate metabolic process",
"P:epithelial cell proliferation",
"P:glycoprotein biosynthetic process",
"P:negative regulation of epithelial cell proliferation",
"P:protein O-linked glycosylation",
"P:protein O-linked glycosylation via N-acetyl-galactosamine"
] |
[
"GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_CARBOHYDRATE_METABOLIC_PROCESS",
"GOBP_EPITHELIAL_CELL_PROLIFERATION",
"GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCOPROTEIN_METABOLIC_PROCESS",
"GOBP_GLYCOSYLATION",
"GOBP_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION",
"GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION",
"GOBP_O_GLYCAN_PROCESSING",
"GOBP_PROTEIN_O_LINKED_GLYCOSYLATION",
"GOBP_REGULATION_OF_CELL_POPULATION_PROLIFERATION",
"GOBP_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION",
"GOCC_GOLGI_APPARATUS",
"GOCC_GOLGI_MEMBRANE",
"GOMF_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY",
"GOMF_GLYCOSYLTRANSFERASE_ACTIVITY",
"GOMF_HEXOSYLTRANSFERASE_ACTIVITY",
"GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY",
"IL21_UP.V1_DN",
"IL2_UP.V1_DN",
"REACTOME_O_LINKED_GLYCOSYLATION",
"REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS",
"REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION"
] |
AAAS
|
Q9NRG9
|
Aladin
|
Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606)
|
[] |
[] |
[
"C:centrosome",
"C:cytosol",
"C:membrane",
"C:mitotic spindle",
"C:nuclear envelope",
"C:nuclear membrane",
"C:nuclear pore",
"C:nucleoplasm",
"C:nucleus",
"C:sperm end piece",
"C:spindle pole",
"P:fertilization",
"P:glutathione metabolic process",
"P:learning",
"P:microtubule bundle formation",
"P:mitotic spindle assembly",
"P:mRNA transport",
"P:multicellular organism growth",
"P:nucleocytoplasmic transport",
"P:protein transport",
"P:regulation of nucleocytoplasmic transport",
"P:response to oxidative stress"
] |
[
"CAMP_UP.V1_UP",
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_BEHAVIOR",
"GOBP_CELL_CYCLE",
"GOBP_CELL_CYCLE_PROCESS",
"GOBP_CHROMOSOME_ORGANIZATION",
"GOBP_CHROMOSOME_SEGREGATION",
"GOBP_COGNITION",
"GOBP_CYTOSKELETON_ORGANIZATION",
"GOBP_DEVELOPMENTAL_GROWTH",
"GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_ESTABLISHMENT_OF_RNA_LOCALIZATION",
"GOBP_FERTILIZATION",
"GOBP_GLUTATHIONE_METABOLIC_PROCESS",
"GOBP_GROWTH",
"GOBP_INTRACELLULAR_TRANSPORT",
"GOBP_LEARNING",
"GOBP_MEMBRANELESS_ORGANELLE_ASSEMBLY",
"GOBP_MICROTUBULE_BASED_PROCESS",
"GOBP_MICROTUBULE_BUNDLE_FORMATION",
"GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION",
"GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS",
"GOBP_MITOTIC_CELL_CYCLE",
"GOBP_MITOTIC_CELL_CYCLE_PROCESS",
"GOBP_MITOTIC_NUCLEAR_DIVISION",
"GOBP_MITOTIC_SISTER_CHROMATID_SEGREGATION",
"GOBP_MITOTIC_SPINDLE_ASSEMBLY",
"GOBP_MITOTIC_SPINDLE_ORGANIZATION",
"GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_MRNA_TRANSPORT",
"GOBP_MULTICELLULAR_ORGANISM_GROWTH",
"GOBP_NERVOUS_SYSTEM_PROCESS",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NUCLEAR_CHROMOSOME_SEGREGATION",
"GOBP_NUCLEAR_TRANSPORT",
"GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT",
"GOBP_ORGANELLE_ASSEMBLY",
"GOBP_ORGANELLE_FISSION",
"GOBP_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_INTRACELLULAR_TRANSPORT",
"GOBP_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_REPRODUCTIVE_PROCESS",
"GOBP_RESPONSE_TO_OXIDATIVE_STRESS",
"GOBP_RNA_LOCALIZATION",
"GOBP_SEXUAL_REPRODUCTION",
"GOBP_SISTER_CHROMATID_SEGREGATION",
"GOBP_SPINDLE_ASSEMBLY",
"GOBP_SPINDLE_ORGANIZATION",
"GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS",
"GOCC_CENTROSOME",
"GOCC_MICROTUBULE_CYTOSKELETON",
"GOCC_MICROTUBULE_ORGANIZING_CENTER",
"GOCC_MITOTIC_SPINDLE",
"GOCC_NUCLEAR_ENVELOPE",
"GOCC_NUCLEAR_MEMBRANE",
"GOCC_NUCLEAR_PORE",
"GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX",
"GOCC_ORGANELLE_ENVELOPE",
"GOCC_SPINDLE",
"GOCC_SPINDLE_POLE",
"HALLMARK_DNA_REPAIR",
"KRAS.600.LUNG.BREAST_UP.V1_DN",
"RB_DN.V1_UP",
"REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES",
"REACTOME_CELLULAR_RESPONSES_TO_STIMULI",
"REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS",
"REACTOME_CELL_CYCLE",
"REACTOME_CELL_CYCLE_MITOTIC",
"REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS",
"REACTOME_GENE_SILENCING_BY_RNA",
"REACTOME_GLUCOSE_METABOLISM",
"REACTOME_HCMV_EARLY_EVENTS",
"REACTOME_HCMV_INFECTION",
"REACTOME_HCMV_LATE_EVENTS",
"REACTOME_HIV_INFECTION",
"REACTOME_HIV_LIFE_CYCLE",
"REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS",
"REACTOME_INFECTIOUS_DISEASE",
"REACTOME_INFLUENZA_INFECTION",
"REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS",
"REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS",
"REACTOME_INTERFERON_SIGNALING",
"REACTOME_ISG15_ANTIVIRAL_MECHANISM",
"REACTOME_METABOLISM_OF_CARBOHYDRATES_AND_CARBOHYDRATE_DERIVATIVES",
"REACTOME_METABOLISM_OF_RNA",
"REACTOME_MITOTIC_PROPHASE",
"REACTOME_M_PHASE",
"REACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS",
"REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN",
"REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN",
"REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY",
"REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION",
"REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA",
"REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN",
"REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE",
"REACTOME_RHOA_GTPASE_CYCLE",
"REACTOME_RHO_GTPASE_CYCLE",
"REACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES",
"REACTOME_SARS_COV_2_HOST_INTERACTIONS",
"REACTOME_SARS_COV_2_INFECTION",
"REACTOME_SARS_COV_INFECTIONS",
"REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3",
"REACTOME_SLC_TRANSPORTER_DISORDERS",
"REACTOME_SNRNP_ASSEMBLY",
"REACTOME_SUMOYLATION",
"REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS",
"REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS",
"REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS",
"REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS",
"REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS",
"REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS",
"REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS",
"REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS",
"REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM",
"REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA",
"REACTOME_TRNA_PROCESSING",
"REACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS",
"REACTOME_VIRAL_INFECTION_PATHWAYS",
"REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS",
"SRC_UP.V1_UP",
"WP_PRADERWILLI_AND_ANGELMAN_SYNDROME"
] |
AACS
|
Q86V21
|
Acetoacetyl-CoA synthetase
|
Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity)
|
[] |
[
"CMTM5"
] |
[
"C:cytosol",
"F:acetoacetate-CoA ligase activity",
"F:ATP binding",
"P:fatty acid metabolic process",
"P:ketone body biosynthetic process",
"P:positive regulation of insulin secretion"
] |
[
"GOBP_AMIDE_TRANSPORT",
"GOBP_CELL_CELL_SIGNALING",
"GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_EXPORT_FROM_CELL",
"GOBP_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS",
"GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY",
"GOBP_HORMONE_TRANSPORT",
"GOBP_INSULIN_SECRETION",
"GOBP_KETONE_BODY_BIOSYNTHETIC_PROCESS",
"GOBP_KETONE_BODY_METABOLIC_PROCESS",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_PEPTIDE_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_SIGNALING",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION",
"GOBP_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_REGULATION_OF_HORMONE_LEVELS",
"GOBP_REGULATION_OF_HORMONE_SECRETION",
"GOBP_REGULATION_OF_INSULIN_SECRETION",
"GOBP_REGULATION_OF_PEPTIDE_TRANSPORT",
"GOBP_REGULATION_OF_PROTEIN_SECRETION",
"GOBP_REGULATION_OF_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_SECRETION",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_SECRETION",
"GOBP_SIGNAL_RELEASE",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOMF_ACID_THIOL_LIGASE_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_COA_LIGASE_ACTIVITY",
"GOMF_LIGASE_ACTIVITY",
"GOMF_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS",
"KEGG_BUTANOATE_METABOLISM",
"REACTOME_KETONE_BODY_METABOLISM",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_SYNTHESIS_OF_KETONE_BODIES"
] |
AADAC
|
P22760
|
Arylacetamide deacetylase
|
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity
|
[] |
[
"APPBP2"
] |
[
"C:endoplasmic reticulum membrane",
"F:catalytic activity",
"F:deacetylase activity",
"F:lipase activity",
"F:serine hydrolase activity",
"F:triacylglycerol lipase activity",
"P:lipid metabolic process",
"P:positive regulation of triglyceride catabolic process",
"P:xenobiotic metabolic process"
] |
[
"ATF2_S_UP.V1_DN",
"ATF2_UP.V1_DN",
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_GLYCEROLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_TRIGLYCERIDE_CATABOLIC_PROCESS",
"GOBP_TRIGLYCERIDE_METABOLIC_PROCESS",
"GOBP_XENOBIOTIC_METABOLIC_PROCESS",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_DEACETYLASE_ACTIVITY",
"GOMF_DEACYLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"GOMF_SERINE_HYDROLASE_ACTIVITY",
"GOMF_TRIACYLGLYCEROL_LIPASE_ACTIVITY",
"KRAS.KIDNEY_UP.V1_DN",
"REACTOME_BIOLOGICAL_OXIDATIONS",
"REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS",
"SRC_UP.V1_UP"
] |
AADACL2
|
Q6P093
|
Arylacetamide deacetylase-like 2
|
[] |
[] |
[
"C:extracellular region",
"C:membrane",
"F:carboxylic ester hydrolase activity"
] |
[
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS"
] |
|
AADACL3
|
Q5VUY0
|
Arylacetamide deacetylase-like 3
|
[] |
[] |
[
"C:membrane",
"F:carboxylic ester hydrolase activity"
] |
[
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS"
] |
|
AADACL4
|
Q5VUY2
|
Arylacetamide deacetylase-like 4
|
[] |
[] |
[
"C:membrane",
"F:carboxylic ester hydrolase activity"
] |
[
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS"
] |
|
AADAT
|
Q8N5Z0
|
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
|
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)
|
[] |
[] |
[
"C:mitochondrial matrix",
"C:mitochondrion",
"F:2-aminoadipate transaminase activity",
"F:glycine:2-oxoglutarate aminotransferase activity",
"F:kynurenine-glyoxylate transaminase activity",
"F:kynurenine-oxoglutarate transaminase activity",
"F:methionine-glyoxylate transaminase activity",
"F:protein homodimerization activity",
"F:pyridoxal phosphate binding",
"P:2-oxoglutarate metabolic process",
"P:alpha-amino acid metabolic process",
"P:glutamate metabolic process",
"P:kynurenine metabolic process",
"P:L-lysine catabolic process to acetyl-CoA via saccharopine"
] |
[
"GOBP_2_OXOGLUTARATE_METABOLIC_PROCESS",
"GOBP_ACETYL_COA_METABOLIC_PROCESS",
"GOBP_ACYL_COA_METABOLIC_PROCESS",
"GOBP_ALPHA_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_AMIDE_CATABOLIC_PROCESS",
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_DICARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_GLUTAMATE_METABOLIC_PROCESS",
"GOBP_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_KETONE_METABOLIC_PROCESS",
"GOBP_KYNURENINE_METABOLIC_PROCESS",
"GOBP_LYSINE_METABOLIC_PROCESS",
"GOBP_L_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_NON_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS",
"GOCC_MITOCHONDRIAL_MATRIX",
"GOCC_MITOCHONDRION",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY",
"GOMF_TRANSAMINASE_ACTIVITY",
"GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS",
"GOMF_VITAMIN_B6_BINDING",
"GOMF_VITAMIN_BINDING",
"HALLMARK_FATTY_ACID_METABOLISM",
"KEGG_LYSINE_DEGRADATION",
"KEGG_TRYPTOPHAN_METABOLISM",
"REACTOME_LYSINE_CATABOLISM",
"REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES",
"REACTOME_TRYPTOPHAN_CATABOLISM",
"WP_ADHD_AND_AUTISM_ASD_PATHWAYS",
"WP_IDO_METABOLIC_PATHWAY",
"WP_KYNURENINE_PATHWAY_AND_LINKS_TO_CELL_SENESCENCE",
"WP_METABOLIC_EPILEPTIC_DISORDERS",
"WP_TRYPTOPHAN_CATABOLISM_LEADING_TO_NAD_PRODUCTION",
"WP_TRYPTOPHAN_METABOLISM"
] |
AAGAB
|
Q6PD74
|
Alpha- and gamma-adaptin-binding protein p34
|
May be involved in endocytic recycling of growth factor receptors such as EGFR
|
[] |
[
"AP1G1",
"AP1S3",
"AP1S3",
"AP2A2",
"AP2S1",
"HEATR1"
] |
[
"C:cytoplasm",
"C:cytosol",
"C:nuclear speck",
"P:protein transport"
] |
[
"GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_PROTEIN_TRANSPORT",
"GOCC_NUCLEAR_BODY",
"GOCC_NUCLEAR_SPECK",
"PDGF_ERK_DN.V1_UP"
] |
AAK1
|
Q2M2I8
|
AP2-associated protein kinase 1
|
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124)
|
[
"Protein kinase"
] |
[
"ATP13A2"
] |
[
"C:cell leading edge",
"C:clathrin-coated pit",
"C:clathrin-coated vesicle",
"C:cytosol",
"C:plasma membrane",
"C:presynapse",
"C:terminal bouton",
"F:AP-2 adaptor complex binding",
"F:ATP binding",
"F:Notch binding",
"F:protein serine kinase activity",
"F:protein serine/threonine kinase activity",
"P:membrane organization",
"P:positive regulation of Notch signaling pathway",
"P:presynaptic endocytosis",
"P:protein phosphorylation",
"P:protein stabilization",
"P:regulation of clathrin-dependent endocytosis",
"P:regulation of protein localization"
] |
[
"GOBP_CLATHRIN_DEPENDENT_ENDOCYTOSIS",
"GOBP_ENDOCYTOSIS",
"GOBP_IMPORT_INTO_CELL",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_NOTCH_SIGNALING_PATHWAY",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_PHOSPHORYLATION",
"GOBP_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY",
"GOBP_POSITIVE_REGULATION_OF_SIGNALING",
"GOBP_PRESYNAPTIC_ENDOCYTOSIS",
"GOBP_PROTEIN_STABILIZATION",
"GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_CLATHRIN_DEPENDENT_ENDOCYTOSIS",
"GOBP_REGULATION_OF_ENDOCYTOSIS",
"GOBP_REGULATION_OF_NOTCH_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_PROTEIN_STABILITY",
"GOBP_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT",
"GOBP_VESICLE_MEDIATED_TRANSPORT",
"GOBP_VESICLE_MEDIATED_TRANSPORT_IN_SYNAPSE",
"GOCC_AXON",
"GOCC_CELL_LEADING_EDGE",
"GOCC_CLATHRIN_COATED_PIT",
"GOCC_CLATHRIN_COATED_VESICLE",
"GOCC_COATED_VESICLE",
"GOCC_DISTAL_AXON",
"GOCC_NEURON_PROJECTION",
"GOCC_NEURON_PROJECTION_TERMINUS",
"GOCC_PRESYNAPSE",
"GOCC_SYNAPSE",
"GOCC_TERMINAL_BOUTON",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_AP_2_ADAPTOR_COMPLEX_BINDING",
"GOMF_KINASE_ACTIVITY",
"GOMF_NOTCH_BINDING",
"GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING",
"GOMF_PROTEIN_KINASE_ACTIVITY",
"GOMF_PROTEIN_SERINE_KINASE_ACTIVITY",
"GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY",
"GOMF_SIGNALING_RECEPTOR_BINDING",
"GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS",
"RAF_UP.V1_UP",
"REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS",
"REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS",
"REACTOME_MEMBRANE_TRAFFICKING",
"REACTOME_VESICLE_MEDIATED_TRANSPORT",
"WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES"
] |
AAMDC
|
Q9H7C9
|
Mth938 domain-containing protein
|
May play a role in preadipocyte differentiation and adipogenesis
|
[] |
[
"ACY3",
"APP",
"ATXN3",
"DNM2",
"GDAP1",
"GORASP2",
"HTT",
"VPS9D1"
] |
[
"C:cytoplasm",
"P:negative regulation of apoptotic process",
"P:positive regulation of fat cell differentiation",
"P:positive regulation of transcription by RNA polymerase II",
"P:transcription by RNA polymerase II"
] |
[
"GOBP_APOPTOTIC_PROCESS",
"GOBP_FAT_CELL_DIFFERENTIATION",
"GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH",
"GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION",
"GOBP_POSITIVE_REGULATION_OF_RNA_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II",
"GOBP_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_FAT_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH"
] |
AAMP
|
Q13685
|
Angio-associated migratory cell protein
|
Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway
|
[] |
[
"AEN",
"AEN"
] |
[
"C:cell surface",
"C:cytosol",
"C:intercellular bridge",
"C:microtubule cytoskeleton",
"C:plasma membrane",
"F:heparin binding",
"P:angiogenesis",
"P:cell differentiation",
"P:positive regulation of endothelial cell migration",
"P:smooth muscle cell migration"
] |
[
"GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS",
"GOBP_BLOOD_VESSEL_MORPHOGENESIS",
"GOBP_CELL_MOTILITY",
"GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT",
"GOBP_ENDOTHELIAL_CELL_MIGRATION",
"GOBP_LOCOMOTION",
"GOBP_MUSCLE_CELL_MIGRATION",
"GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION",
"GOBP_POSITIVE_REGULATION_OF_LOCOMOTION",
"GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION",
"GOBP_REGULATION_OF_LOCOMOTION",
"GOBP_SMOOTH_MUSCLE_CELL_MIGRATION",
"GOBP_TUBE_DEVELOPMENT",
"GOBP_TUBE_MORPHOGENESIS",
"GOBP_VASCULATURE_DEVELOPMENT",
"GOCC_CELL_SURFACE",
"GOCC_INTERCELLULAR_BRIDGE",
"GOCC_MICROTUBULE_CYTOSKELETON",
"GOMF_GLYCOSAMINOGLYCAN_BINDING",
"GOMF_HEPARIN_BINDING",
"GOMF_SULFUR_COMPOUND_BINDING",
"REACTOME_HEMOSTASIS",
"REACTOME_INNATE_IMMUNE_SYSTEM",
"REACTOME_NOD1_2_SIGNALING_PATHWAY",
"REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS",
"REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION",
"REACTOME_SIGNALING_BY_EGFR",
"REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES",
"REACTOME_SIGNALING_BY_VEGF",
"REACTOME_SIGNAL_AMPLIFICATION",
"REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR",
"WP_NUCLEOTIDEBINDING_OLIGOMERIZATION_DOMAIN_NOD_PATHWAY"
] |
AANAT
|
Q16613
|
Serotonin N-acetyltransferase
|
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin
|
[
"N-acetyltransferase"
] |
[
"BHLHE40",
"EIF4E3",
"GRB10",
"KRTAP8-1",
"MDFI"
] |
[
"C:cytoplasm",
"C:cytosol",
"C:perinuclear region of cytoplasm",
"F:14-3-3 protein binding",
"F:aralkylamine N-acetyltransferase activity",
"F:arylamine N-acetyltransferase activity",
"P:cellular response to cAMP",
"P:circadian rhythm",
"P:indolalkylamine biosynthetic process",
"P:melatonin biosynthetic process",
"P:N-terminal protein amino acid acetylation",
"P:photoperiodism",
"P:response to calcium ion",
"P:response to copper ion",
"P:response to corticosterone",
"P:response to cytokine",
"P:response to insulin",
"P:response to light stimulus",
"P:response to prostaglandin E",
"P:response to zinc ion"
] |
[
"GOBP_AMIDE_BIOSYNTHETIC_PROCESS",
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_AMINE_BIOSYNTHETIC_PROCESS",
"GOBP_AMINE_METABOLIC_PROCESS",
"GOBP_CELLULAR_RESPONSE_TO_CAMP",
"GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_CIRCADIAN_RHYTHM",
"GOBP_HORMONE_BIOSYNTHETIC_PROCESS",
"GOBP_HORMONE_METABOLIC_PROCESS",
"GOBP_INDOLALKYLAMINE_METABOLIC_PROCESS",
"GOBP_INDOLE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS",
"GOBP_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION",
"GOBP_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION",
"GOBP_PHOTOPERIODISM",
"GOBP_PROTEIN_ACETYLATION",
"GOBP_PROTEIN_ACYLATION",
"GOBP_PROTEIN_MATURATION",
"GOBP_REGULATION_OF_HORMONE_LEVELS",
"GOBP_RESPONSE_TO_ABIOTIC_STIMULUS",
"GOBP_RESPONSE_TO_ALCOHOL",
"GOBP_RESPONSE_TO_CALCIUM_ION",
"GOBP_RESPONSE_TO_CAMP",
"GOBP_RESPONSE_TO_COPPER_ION",
"GOBP_RESPONSE_TO_CORTICOSTEROID",
"GOBP_RESPONSE_TO_CORTICOSTERONE",
"GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS",
"GOBP_RESPONSE_TO_HORMONE",
"GOBP_RESPONSE_TO_INSULIN",
"GOBP_RESPONSE_TO_KETONE",
"GOBP_RESPONSE_TO_LIGHT_STIMULUS",
"GOBP_RESPONSE_TO_LIPID",
"GOBP_RESPONSE_TO_METAL_ION",
"GOBP_RESPONSE_TO_MINERALOCORTICOID",
"GOBP_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_RESPONSE_TO_ORGANOPHOSPHORUS",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_PEPTIDE",
"GOBP_RESPONSE_TO_PEPTIDE_HORMONE",
"GOBP_RESPONSE_TO_PROSTAGLANDIN",
"GOBP_RESPONSE_TO_PROSTAGLANDIN_E",
"GOBP_RESPONSE_TO_PURINE_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_RADIATION",
"GOBP_RESPONSE_TO_STEROID_HORMONE",
"GOBP_RESPONSE_TO_ZINC_ION",
"GOBP_RHYTHMIC_PROCESS",
"GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM",
"GOMF_14_3_3_PROTEIN_BINDING",
"GOMF_ACETYLTRANSFERASE_ACTIVITY",
"GOMF_ACYLTRANSFERASE_ACTIVITY",
"GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS",
"GOMF_N_ACETYLTRANSFERASE_ACTIVITY",
"GOMF_N_ACYLTRANSFERASE_ACTIVITY",
"KEGG_TRYPTOPHAN_METABOLISM",
"PRC1_BMI_UP.V1_DN",
"REACTOME_METABOLISM_OF_AMINE_DERIVED_HORMONES",
"REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES",
"REACTOME_SEROTONIN_AND_MELATONIN_BIOSYNTHESIS",
"WP_ADHD_AND_AUTISM_ASD_PATHWAYS",
"WP_BIOGENIC_AMINE_SYNTHESIS",
"WP_BIOSYNTHESIS_AND_REGENERATION_OF_TETRAHYDROBIOPTERIN_AND_CATABOLISM_OF_PHENYLALANINE",
"WP_CIRCADIAN_RHYTHM_GENES",
"WP_MELATONIN_METABOLISM_AND_EFFECTS",
"WP_TRYPTOPHAN_METABOLISM"
] |
AAR2
|
Q9Y312
|
Protein AAR2 homolog
|
Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing
|
[] |
[] |
[
"C:spliceosomal complex",
"C:U5 snRNP",
"P:spliceosomal tri-snRNP complex assembly"
] |
[
"GOBP_MRNA_METABOLIC_PROCESS",
"GOBP_MRNA_PROCESSING",
"GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION",
"GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION",
"GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS",
"GOBP_RNA_PROCESSING",
"GOBP_RNA_SPLICING",
"GOBP_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS",
"GOBP_SPLICEOSOMAL_SNRNP_ASSEMBLY",
"GOBP_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY",
"GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX",
"GOCC_RIBONUCLEOPROTEIN_COMPLEX",
"GOCC_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX",
"GOCC_SM_LIKE_PROTEIN_FAMILY_COMPLEX",
"GOCC_SPLICEOSOMAL_COMPLEX",
"GOCC_U5_SNRNP",
"WP_CILIARY_LANDSCAPE"
] |
AARD
|
Q4LEZ3
|
Alanine- and arginine-rich domain-containing protein
|
[] |
[
"CENPQ",
"CEP57",
"GRIPAP1",
"KIAA0753",
"KRT24",
"KRT27",
"LMO4",
"MAGEB4",
"NTAQ1",
"STX1A",
"STX2",
"STX5",
"TFIP11",
"TSGA10",
"VPS37C"
] |
[
"P:response to testosterone"
] |
[
"GCNP_SHH_UP_LATE.V1_UP",
"GOBP_RESPONSE_TO_KETONE",
"GOBP_RESPONSE_TO_LIPID",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_TESTOSTERONE",
"WNT_UP.V1_DN"
] |
|
AARS1
|
P49588
|
Alanine--tRNA ligase, cytoplasmic
|
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451)
|
[] |
[] |
[
"C:cytoplasm",
"C:cytosol",
"C:extracellular exosome",
"C:membrane",
"C:nucleus",
"F:alanine-tRNA ligase activity",
"F:amino acid binding",
"F:aminoacyl-tRNA deacylase activity",
"F:ATP binding",
"F:peptide lactyltransferase (ATP-dependent) activity",
"F:Ser-tRNA(Ala) deacylase activity",
"F:tRNA binding",
"F:zinc ion binding",
"P:alanyl-tRNA aminoacylation",
"P:cerebellar Purkinje cell layer development",
"P:negative regulation of neuron apoptotic process",
"P:negative regulation of signal transduction by p53 class mediator",
"P:neuromuscular process controlling balance",
"P:neuron apoptotic process",
"P:positive regulation of hippo signaling",
"P:regulation of cytoplasmic translational fidelity",
"P:tRNA aminoacylation for protein translation",
"P:tRNA modification",
"P:tRNA processing"
] |
[
"CAMP_UP.V1_UP",
"GOBP_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY",
"GOBP_AMINO_ACID_ACTIVATION",
"GOBP_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_APOPTOTIC_PROCESS",
"GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT",
"GOBP_CEREBELLAR_CORTEX_DEVELOPMENT",
"GOBP_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT",
"GOBP_CYTOPLASMIC_TRANSLATION",
"GOBP_CYTOPLASMIC_TRANSLATIONAL_ELONGATION",
"GOBP_HEAD_DEVELOPMENT",
"GOBP_HINDBRAIN_DEVELOPMENT",
"GOBP_HIPPO_SIGNALING",
"GOBP_METENCEPHALON_DEVELOPMENT",
"GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION",
"GOBP_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH",
"GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS",
"GOBP_NEGATIVE_REGULATION_OF_SIGNALING",
"GOBP_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR",
"GOBP_NERVOUS_SYSTEM_PROCESS",
"GOBP_NEUROMUSCULAR_PROCESS",
"GOBP_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE",
"GOBP_NEURON_APOPTOTIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_HIPPO_SIGNALING",
"GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION",
"GOBP_POSITIVE_REGULATION_OF_SIGNALING",
"GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION",
"GOBP_REGULATION_OF_HIPPO_SIGNALING",
"GOBP_REGULATION_OF_NEURON_APOPTOTIC_PROCESS",
"GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH",
"GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR",
"GOBP_REGULATION_OF_TRANSLATION",
"GOBP_REGULATION_OF_TRANSLATIONAL_ELONGATION",
"GOBP_REGULATION_OF_TRANSLATIONAL_FIDELITY",
"GOBP_RNA_MODIFICATION",
"GOBP_RNA_PROCESSING",
"GOBP_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR",
"GOBP_TRANSLATION",
"GOBP_TRANSLATIONAL_ELONGATION",
"GOBP_TRNA_METABOLIC_PROCESS",
"GOBP_TRNA_MODIFICATION",
"GOBP_TRNA_PROCESSING",
"GOCC_MITOCHONDRION",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_AMINOACYL_TRNA_DEACYLASE_ACTIVITY",
"GOMF_AMINO_ACID_BINDING",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA",
"GOMF_LIGASE_ACTIVITY",
"GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS",
"GOMF_LIGASE_ACTIVITY_FORMING_PHOSPHORIC_ESTER_BONDS",
"GOMF_TRNA_BINDING",
"HALLMARK_ALLOGRAFT_REJECTION",
"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",
"RB_P107_DN.V1_DN",
"REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION",
"REACTOME_TRANSLATION",
"REACTOME_TRNA_AMINOACYLATION",
"WP_IL18_SIGNALING"
] |
AARS2
|
Q5JTZ9
|
Alanine--tRNA ligase, mitochondrial
|
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:21549344). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS (PubMed:39322678). Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:39322678)
|
[] |
[
"EHHADH",
"PTPA"
] |
[
"C:mitochondrion",
"F:alanine-tRNA ligase activity",
"F:aminoacyl-tRNA deacylase activity",
"F:ATP binding",
"F:peptide lactyltransferase (ATP-dependent) activity",
"F:tRNA binding",
"F:zinc ion binding",
"P:mitochondrial alanyl-tRNA aminoacylation",
"P:negative regulation of cGAS/STING signaling pathway"
] |
[
"GOBP_ACTIVATION_OF_IMMUNE_RESPONSE",
"GOBP_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE",
"GOBP_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY",
"GOBP_AMINO_ACID_ACTIVATION",
"GOBP_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS",
"GOBP_CGAS_STING_SIGNALING_PATHWAY",
"GOBP_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM",
"GOBP_DEFENSE_RESPONSE_TO_SYMBIONT",
"GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY",
"GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_MITOCHONDRIAL_GENE_EXPRESSION",
"GOBP_MITOCHONDRIAL_RNA_METABOLIC_PROCESS",
"GOBP_MITOCHONDRIAL_TRANSLATION",
"GOBP_NEGATIVE_REGULATION_OF_CGAS_STING_SIGNALING_PATHWAY",
"GOBP_NEGATIVE_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION",
"GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS",
"GOBP_NEGATIVE_REGULATION_OF_SIGNALING",
"GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE",
"GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS",
"GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_REGULATION_OF_IMMUNE_RESPONSE",
"GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE",
"GOBP_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS",
"GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_REGULATION_OF_RESPONSE_TO_STRESS",
"GOBP_REGULATION_OF_TRANSLATIONAL_FIDELITY",
"GOBP_TRANSLATION",
"GOBP_TRNA_AMINOACYLATION_FOR_MITOCHONDRIAL_PROTEIN_TRANSLATION",
"GOBP_TRNA_METABOLIC_PROCESS",
"GOCC_MITOCHONDRION",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_AMINOACYL_TRNA_DEACYLASE_ACTIVITY",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA",
"GOMF_LIGASE_ACTIVITY",
"GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS",
"GOMF_LIGASE_ACTIVITY_FORMING_PHOSPHORIC_ESTER_BONDS",
"GOMF_TRNA_BINDING",
"KEGG_AMINOACYL_TRNA_BIOSYNTHESIS",
"REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION",
"REACTOME_TRANSLATION",
"REACTOME_TRNA_AMINOACYLATION",
"WP_PRIMARY_OVARIAN_INSUFFICIENCY"
] |
AARSD1
|
Q9BTE6
|
Alanyl-tRNA editing protein Aarsd1
|
Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala)
|
[] |
[
"ARID4B",
"DYNLT1",
"FAAP100",
"MLF1",
"SPANXN3",
"TRIM45",
"ZMYND19",
"ZNF185"
] |
[
"C:cytoplasm",
"C:nucleus",
"F:alanine-tRNA ligase activity",
"F:ATP binding",
"F:metal ion binding",
"F:nucleic acid binding",
"F:Ser-tRNA(Ala) deacylase activity",
"P:alanyl-tRNA aminoacylation",
"P:regulation of translational fidelity"
] |
[
"GOBP_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY",
"GOBP_AMINO_ACID_ACTIVATION",
"GOBP_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_TRANSLATIONAL_FIDELITY",
"GOBP_TRANSLATION",
"GOBP_TRNA_METABOLIC_PROCESS",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_AMINOACYL_TRNA_DEACYLASE_ACTIVITY",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA",
"GOMF_LIGASE_ACTIVITY",
"GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS"
] |
AASDH
|
Q4L235
|
Beta-alanine-activating enzyme
|
Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA
|
[
"Carrier"
] |
[] |
[
"F:ATP binding",
"F:ligase activity",
"P:amino acid activation for nonribosomal peptide biosynthetic process",
"P:beta-alanine metabolic process",
"P:fatty acid metabolic process"
] |
[
"GOBP_AMINO_ACID_ACTIVATION",
"GOBP_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS",
"GOBP_NON_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_PEPTIDE_BIOSYNTHETIC_PROCESS",
"GOBP_PEPTIDE_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOMF_ACID_THIOL_LIGASE_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_LIGASE_ACTIVITY",
"GOMF_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS",
"KEGG_LYSINE_DEGRADATION"
] |
AASDHPPT
|
Q9NRN7
|
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
|
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN
|
[] |
[
"CRX",
"EFHC2",
"SIAH1",
"TRAF2",
"USP22",
"USP22"
] |
[
"C:cytosol",
"C:extracellular exosome",
"F:holo-[acyl-carrier-protein] synthase activity",
"F:magnesium ion binding",
"P:10-formyltetrahydrofolate catabolic process",
"P:lysine biosynthetic process via aminoadipic acid",
"P:pantothenate metabolic process",
"P:protein maturation"
] |
[
"ERBB2_UP.V1_DN",
"GOBP_10_FORMYLTETRAHYDROFOLATE_METABOLIC_PROCESS",
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_DICARBOXYLIC_ACID_CATABOLIC_PROCESS",
"GOBP_DICARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_PANTOTHENATE_METABOLIC_PROCESS",
"GOBP_PROTEIN_MATURATION",
"GOBP_PTERIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS",
"GOBP_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_TETRAHYDROFOLATE_METABOLIC_PROCESS",
"GOBP_VITAMIN_METABOLIC_PROCESS",
"GOBP_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS",
"GOMF_MAGNESIUM_ION_BINDING",
"GOMF_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS",
"GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS",
"KEGG_LYSINE_DEGRADATION",
"REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS",
"REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS",
"REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM"
] |
AASS
|
Q9UDR5
|
Alpha-aminoadipic semialdehyde synthase, mitochondrial
|
Bifunctional enzyme that catalyzes the first two steps in lysine degradation
|
[] |
[] |
[
"C:cytoplasm",
"C:cytosol",
"C:mitochondrial matrix",
"C:mitochondrion",
"C:nucleus",
"F:histone binding",
"F:saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity",
"F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity",
"F:saccharopine dehydrogenase (NADP+, L-lysine-forming) activity",
"F:saccharopine dehydrogenase activity",
"F:transcription corepressor activity",
"P:L-lysine catabolic process to acetyl-CoA via saccharopine",
"P:lysine biosynthetic process via aminoadipic acid",
"P:lysine catabolic process",
"P:negative regulation of transcription by RNA polymerase II"
] |
[
"GOBP_ACETYL_COA_METABOLIC_PROCESS",
"GOBP_ACYL_COA_METABOLIC_PROCESS",
"GOBP_ALPHA_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_AMIDE_CATABOLIC_PROCESS",
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_LYSINE_METABOLIC_PROCESS",
"GOBP_L_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_RNA_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II",
"GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS",
"GOCC_MITOCHONDRIAL_MATRIX",
"GOCC_MITOCHONDRION",
"GOMF_HISTONE_BINDING",
"GOMF_MOLECULAR_ADAPTOR_ACTIVITY",
"GOMF_OXIDOREDUCTASE_ACTIVITY",
"GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS",
"GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR",
"GOMF_TRANSCRIPTION_COREGULATOR_ACTIVITY",
"GOMF_TRANSCRIPTION_COREPRESSOR_ACTIVITY",
"GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY",
"KEGG_LYSINE_DEGRADATION",
"REACTOME_LYSINE_CATABOLISM",
"REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES",
"VEGF_A_UP.V1_DN",
"WP_METABOLIC_EPILEPTIC_DISORDERS"
] |
AATF
|
Q9NY61
|
Protein AATF
|
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date
|
[] |
[
"APP",
"ATM",
"CHEK2",
"KAT2A",
"MNS1",
"NGDN",
"PIK3R1",
"POLR2J",
"RAC1",
"RBBP8",
"RELA",
"SP1",
"TADA2A",
"TADA2B",
"TADA3",
"Myl12a"
] |
[
"C:cytoplasm",
"C:nucleolus",
"C:nucleoplasm",
"C:nucleus",
"C:small-subunit processome",
"C:transcription regulator complex",
"F:leucine zipper domain binding",
"F:RNA binding",
"P:cell adhesion",
"P:embryonic cleavage",
"P:negative regulation of amyloid precursor protein biosynthetic process",
"P:negative regulation of apoptotic signaling pathway",
"P:regulation of mitotic cell cycle",
"P:ribosomal small subunit biogenesis"
] |
[
"CAMP_UP.V1_UP",
"GOBP_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS",
"GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS",
"GOBP_APOPTOTIC_PROCESS",
"GOBP_APOPTOTIC_SIGNALING_PATHWAY",
"GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_CELL_ADHESION",
"GOBP_CELL_CYCLE",
"GOBP_CELL_DIVISION",
"GOBP_EMBRYONIC_CLEAVAGE",
"GOBP_EMBRYO_DEVELOPMENT",
"GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCOPROTEIN_METABOLIC_PROCESS",
"GOBP_MITOTIC_CELL_CYCLE",
"GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY",
"GOBP_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS",
"GOBP_NEGATIVE_REGULATION_OF_SIGNALING",
"GOBP_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_CELL_CYCLE",
"GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_MITOTIC_CELL_CYCLE",
"GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH",
"GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS",
"GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS",
"GOBP_RIBOSOME_BIOGENESIS",
"GOCC_NUCLEOLUS",
"GOCC_PRERIBOSOME",
"GOCC_RIBONUCLEOPROTEIN_COMPLEX",
"GOCC_SMALL_SUBUNIT_PROCESSOME",
"GOCC_TRANSCRIPTION_REGULATOR_COMPLEX",
"GOMF_LEUCINE_ZIPPER_DOMAIN_BINDING",
"GOMF_LRR_DOMAIN_BINDING",
"GOMF_PROTEIN_DOMAIN_SPECIFIC_BINDING",
"PID_RB_1PATHWAY",
"REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE",
"REACTOME_DEATH_RECEPTOR_SIGNALING",
"REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK",
"REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING",
"WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME"
] |
AATK
|
Q6ZMQ8
|
Serine/threonine-protein kinase LMTK1
|
May be involved in neuronal differentiation
|
[
"Protein kinase"
] |
[
"PPP1CA",
"PPP1CC",
"TEPSIN",
"CDK5R1",
"CDK5R1"
] |
[
"C:endomembrane system",
"C:membrane",
"C:perinuclear region of cytoplasm",
"F:ATP binding",
"F:protein serine kinase activity",
"F:protein serine/threonine kinase activity",
"F:protein tyrosine kinase activity",
"P:brain development",
"P:neuron apoptotic process"
] |
[
"GOBP_APOPTOTIC_PROCESS",
"GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT",
"GOBP_HEAD_DEVELOPMENT",
"GOBP_NEURON_APOPTOTIC_PROCESS",
"GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_KINASE_ACTIVITY",
"GOMF_PROTEIN_KINASE_ACTIVITY",
"GOMF_PROTEIN_SERINE_KINASE_ACTIVITY",
"GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY",
"GOMF_PROTEIN_TYROSINE_KINASE_ACTIVITY",
"GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS",
"IL21_UP.V1_UP",
"IL2_UP.V1_UP",
"KRAS.AMP.LUNG_UP.V1_DN",
"KRAS.PROSTATE_UP.V1_DN",
"PRC1_BMI_UP.V1_UP",
"PRC2_EED_DN.V1_UP",
"PRC2_EZH2_UP.V1_UP",
"PRC2_SUZ12_UP.V1_UP"
] |
ABAT
|
P80404
|
4-aminobutyrate aminotransferase, mitochondrial
|
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine (By similarity)
|
[] |
[] |
[
"C:4-aminobutyrate transaminase complex",
"C:mitochondrial matrix",
"C:mitochondrion",
"F:(S)-3-amino-2-methylpropionate transaminase activity",
"F:4-aminobutyrate:2-oxoglutarate transaminase activity",
"F:identical protein binding",
"F:iron-sulfur cluster binding",
"F:metal ion binding",
"F:pyridoxal phosphate binding",
"F:succinate-semialdehyde dehydrogenase binding",
"P:cerebellum development",
"P:copulation",
"P:exploration behavior",
"P:gamma-aminobutyric acid biosynthetic process",
"P:gamma-aminobutyric acid catabolic process",
"P:gamma-aminobutyric acid metabolic process",
"P:locomotory behavior",
"P:negative regulation of blood pressure",
"P:negative regulation of dopamine secretion",
"P:negative regulation of gamma-aminobutyric acid secretion",
"P:nervous system process",
"P:positive regulation of aspartate secretion",
"P:positive regulation of dopamine metabolic process",
"P:positive regulation of heat generation",
"P:positive regulation of inhibitory postsynaptic potential",
"P:positive regulation of insulin secretion",
"P:positive regulation of prolactin secretion",
"P:positive regulation of uterine smooth muscle contraction",
"P:response to cocaine",
"P:response to ethanol",
"P:response to hypoxia",
"P:response to iron ion",
"P:response to nicotine",
"P:response to xenobiotic stimulus"
] |
[
"GOBP_ACIDIC_AMINO_ACID_TRANSPORT",
"GOBP_ACID_SECRETION",
"GOBP_AMIDE_TRANSPORT",
"GOBP_AMINE_METABOLIC_PROCESS",
"GOBP_AMINE_TRANSPORT",
"GOBP_AMINO_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_AMINO_ACID_TRANSPORT",
"GOBP_BEHAVIOR",
"GOBP_C4_DICARBOXYLATE_TRANSPORT",
"GOBP_CATECHOLAMINE_SECRETION",
"GOBP_CATECHOLAMINE_TRANSPORT",
"GOBP_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_CELL_CELL_SIGNALING",
"GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT",
"GOBP_CHEMICAL_SYNAPTIC_TRANSMISSION_POSTSYNAPTIC",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_COPULATION",
"GOBP_DICARBOXYLIC_ACID_TRANSPORT",
"GOBP_DOPAMINE_METABOLIC_PROCESS",
"GOBP_DOPAMINE_SECRETION",
"GOBP_DOPAMINE_TRANSPORT",
"GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_EXPLORATION_BEHAVIOR",
"GOBP_EXPORT_FROM_CELL",
"GOBP_GAMMA_AMINOBUTYRIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_GAMMA_AMINOBUTYRIC_ACID_METABOLIC_PROCESS",
"GOBP_GAMMA_AMINOBUTYRIC_ACID_SECRETION",
"GOBP_GAMMA_AMINOBUTYRIC_ACID_TRANSPORT",
"GOBP_HEAD_DEVELOPMENT",
"GOBP_HEAT_GENERATION",
"GOBP_HINDBRAIN_DEVELOPMENT",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_HORMONE_TRANSPORT",
"GOBP_INHIBITORY_POSTSYNAPTIC_POTENTIAL",
"GOBP_INSULIN_SECRETION",
"GOBP_LOCOMOTORY_BEHAVIOR",
"GOBP_MATING_BEHAVIOR",
"GOBP_METENCEPHALON_DEVELOPMENT",
"GOBP_MODULATION_OF_INHIBITORY_POSTSYNAPTIC_POTENTIAL",
"GOBP_MONOAMINE_TRANSPORT",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS",
"GOBP_MULTICELLULAR_ORGANISMAL_REPRODUCTIVE_PROCESS",
"GOBP_MUSCLE_CONTRACTION",
"GOBP_MUSCLE_SYSTEM_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT",
"GOBP_NEGATIVE_REGULATION_OF_AMINO_ACID_TRANSPORT",
"GOBP_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE",
"GOBP_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION",
"GOBP_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT",
"GOBP_NEGATIVE_REGULATION_OF_SECRETION",
"GOBP_NEGATIVE_REGULATION_OF_TRANSPORT",
"GOBP_NERVOUS_SYSTEM_PROCESS",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NON_PROTEINOGENIC_AMINO_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_NON_PROTEINOGENIC_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_NON_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_PEPTIDE_TRANSPORT",
"GOBP_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_AMINE_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_AMINE_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_HEAT_GENERATION",
"GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION",
"GOBP_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_SIGNALING",
"GOBP_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_UTERINE_SMOOTH_MUSCLE_CONTRACTION",
"GOBP_PROLACTIN_SECRETION",
"GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION",
"GOBP_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_AMINE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_AMINO_ACID_TRANSPORT",
"GOBP_REGULATION_OF_BLOOD_PRESSURE",
"GOBP_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_CATECHOLAMINE_SECRETION",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_DOPAMINE_SECRETION",
"GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_REGULATION_OF_GAMMA_AMINOBUTYRIC_ACID_SECRETION",
"GOBP_REGULATION_OF_HEAT_GENERATION",
"GOBP_REGULATION_OF_HORMONE_LEVELS",
"GOBP_REGULATION_OF_HORMONE_SECRETION",
"GOBP_REGULATION_OF_INSULIN_SECRETION",
"GOBP_REGULATION_OF_MEMBRANE_POTENTIAL",
"GOBP_REGULATION_OF_MUSCLE_CONTRACTION",
"GOBP_REGULATION_OF_MUSCLE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_NERVOUS_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_ORGANIC_ACID_TRANSPORT",
"GOBP_REGULATION_OF_PEPTIDE_TRANSPORT",
"GOBP_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL",
"GOBP_REGULATION_OF_PROTEIN_SECRETION",
"GOBP_REGULATION_OF_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_SECRETION",
"GOBP_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION",
"GOBP_REGULATION_OF_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_REPRODUCTIVE_BEHAVIOR",
"GOBP_REPRODUCTIVE_PROCESS",
"GOBP_RESPONSE_TO_ABIOTIC_STIMULUS",
"GOBP_RESPONSE_TO_ALCOHOL",
"GOBP_RESPONSE_TO_ALKALOID",
"GOBP_RESPONSE_TO_COCAINE",
"GOBP_RESPONSE_TO_ETHANOL",
"GOBP_RESPONSE_TO_IRON_ION",
"GOBP_RESPONSE_TO_METAL_ION",
"GOBP_RESPONSE_TO_NICOTINE",
"GOBP_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_OXYGEN_LEVELS",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_SECRETION",
"GOBP_SIGNAL_RELEASE",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_SMOOTH_MUSCLE_CONTRACTION",
"GOBP_SYNAPTIC_SIGNALING",
"GOBP_TEMPERATURE_HOMEOSTASIS",
"GOBP_UTERINE_SMOOTH_MUSCLE_CONTRACTION",
"GOCC_CATALYTIC_COMPLEX",
"GOCC_INTRACELLULAR_PROTEIN_CONTAINING_COMPLEX",
"GOCC_MITOCHONDRIAL_MATRIX",
"GOCC_MITOCHONDRION",
"GOCC_TRANSFERASE_COMPLEX",
"GOMF_METAL_CLUSTER_BINDING",
"GOMF_TRANSAMINASE_ACTIVITY",
"GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS",
"GOMF_VITAMIN_B6_BINDING",
"GOMF_VITAMIN_BINDING",
"HALLMARK_ESTROGEN_RESPONSE_EARLY",
"HALLMARK_P53_PATHWAY",
"KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM",
"KEGG_BETA_ALANINE_METABOLISM",
"KEGG_BUTANOATE_METABOLISM",
"KEGG_PROPANOATE_METABOLISM",
"KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",
"RAF_UP.V1_DN",
"RB_P107_DN.V1_UP",
"REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION",
"REACTOME_NEURONAL_SYSTEM",
"REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE",
"REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES",
"WP_ADHD_AND_AUTISM_ASD_PATHWAYS",
"WP_ALANINE_AND_ASPARTATE_METABOLISM",
"WP_FRAGILE_X_SYNDROME",
"WP_GABA_METABOLISM_AKA_GHB",
"WP_GABA_RECEPTOR_SIGNALING",
"WP_PYRIMIDINE_METABOLISM_AND_RELATED_DISEASES",
"WP_VALPROIC_ACID_PATHWAY"
] |
ABCA1
|
O95477
|
Phospholipid-transporting ATPase ABCA1
|
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981, PubMed:35974019). Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981, PubMed:35974019). Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain (PubMed:35974019)
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[
"ABCA12",
"APOA1",
"ARHGEF11",
"CANX",
"CDC42",
"DLG1",
"DLG2",
"DLG3",
"DLG4",
"LIN7B",
"MAGI2",
"MPDZ",
"PATJ",
"SCRIB",
"SNTA1",
"SNTB1",
"SNTB2",
"STX12"
] |
[
"C:basolateral plasma membrane",
"C:endocytic vesicle",
"C:endoplasmic reticulum membrane",
"C:endosome",
"C:external side of plasma membrane",
"C:Golgi apparatus",
"C:intracellular vesicle",
"C:membrane raft",
"C:perinuclear region of cytoplasm",
"C:phagocytic vesicle",
"C:plasma membrane",
"F:ABC-type transporter activity",
"F:apolipoprotein A-I binding",
"F:apolipoprotein A-I receptor activity",
"F:apolipoprotein binding",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase binding",
"F:ATPase-coupled transmembrane transporter activity",
"F:cholesterol binding",
"F:cholesterol transfer activity",
"F:floppase activity",
"F:high-density lipoprotein particle binding",
"F:phosphatidylcholine binding",
"F:phosphatidylcholine floppase activity",
"F:phosphatidylserine floppase activity",
"F:phospholipid transporter activity",
"F:protein transmembrane transporter activity",
"F:signaling receptor binding",
"F:small GTPase binding",
"F:sphingolipid floppase activity",
"F:syntaxin binding",
"P:adenylate cyclase-activating G protein-coupled receptor signaling pathway",
"P:cellular response to cholesterol",
"P:cellular response to cytokine stimulus",
"P:cellular response to lipopolysaccharide",
"P:cellular response to low-density lipoprotein particle stimulus",
"P:cellular response to retinoic acid",
"P:cellular response to xenobiotic stimulus",
"P:cholesterol efflux",
"P:cholesterol homeostasis",
"P:cholesterol metabolic process",
"P:endosomal transport",
"P:export across plasma membrane",
"P:G protein-coupled receptor signaling pathway",
"P:high-density lipoprotein particle assembly",
"P:intracellular cholesterol transport",
"P:lipoprotein biosynthetic process",
"P:lysosome organization",
"P:negative regulation of cholesterol storage",
"P:negative regulation of macrophage derived foam cell differentiation",
"P:peptide secretion",
"P:phagocytosis, engulfment",
"P:phospholipid efflux",
"P:phospholipid homeostasis",
"P:phospholipid translocation",
"P:platelet dense granule organization",
"P:positive regulation of cholesterol efflux",
"P:positive regulation of high-density lipoprotein particle assembly",
"P:protein secretion",
"P:protein transmembrane transport",
"P:regulation of Cdc42 protein signal transduction",
"P:regulation of high-density lipoprotein particle assembly",
"P:response to laminar fluid shear stress",
"P:response to vitamin B3",
"P:reverse cholesterol transport",
"P:signal release"
] |
[
"BIOCARTA_FXR_PATHWAY",
"BIOCARTA_NUCLEARRS_PATHWAY",
"BMI1_DN.V1_UP",
"BMI1_DN_MEL18_DN.V1_UP",
"GOBP_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_ALCOHOL_METABOLIC_PROCESS",
"GOBP_AMIDE_TRANSPORT",
"GOBP_APOLIPOPROTEIN_A_I_MEDIATED_SIGNALING_PATHWAY",
"GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS",
"GOBP_CDC42_PROTEIN_SIGNAL_TRANSDUCTION",
"GOBP_CELLULAR_RESPONSE_TO_ALCOHOL",
"GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_CHOLESTEROL",
"GOBP_CELLULAR_RESPONSE_TO_LIPID",
"GOBP_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN",
"GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_CELLULAR_RESPONSE_TO_RETINOIC_ACID",
"GOBP_CELLULAR_RESPONSE_TO_STEROL",
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_CELL_CELL_SIGNALING",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_CHOLESTEROL_STORAGE",
"GOBP_ENDOCYTOSIS",
"GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION",
"GOBP_ENDOSOMAL_TRANSPORT",
"GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_EXPORT_FROM_CELL",
"GOBP_FOAM_CELL_DIFFERENTIATION",
"GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_IMPORT_INTO_CELL",
"GOBP_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_INTRACELLULAR_STEROL_TRANSPORT",
"GOBP_INTRACELLULAR_TRANSPORT",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LIPOPROTEIN_BIOSYNTHETIC_PROCESS",
"GOBP_LIPOPROTEIN_METABOLIC_PROCESS",
"GOBP_LYTIC_VACUOLE_ORGANIZATION",
"GOBP_MEMBRANE_INVAGINATION",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_STORAGE",
"GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_LIPID_STORAGE",
"GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NUTRIENT_STORAGE",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PEPTIDE_TRANSPORT",
"GOBP_PHAGOCYTOSIS",
"GOBP_PHAGOCYTOSIS_ENGULFMENT",
"GOBP_PHOSPHOLIPID_EFFLUX",
"GOBP_PHOSPHOLIPID_HOMEOSTASIS",
"GOBP_PHOSPHOLIPID_TRANSLOCATION",
"GOBP_PHOSPHOLIPID_TRANSPORT",
"GOBP_PLATELET_DENSE_GRANULE_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS",
"GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY",
"GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION",
"GOBP_PROTEIN_LIPID_COMPLEX_ASSEMBLY",
"GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION",
"GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION",
"GOBP_PROTEIN_TRANSMEMBRANE_TRANSPORT",
"GOBP_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_CDC42_PROTEIN_SIGNAL_TRANSDUCTION",
"GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS",
"GOBP_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_REGULATION_OF_CHOLESTEROL_STORAGE",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_STORAGE",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION",
"GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS",
"GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY",
"GOBP_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION",
"GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_RESPONSE_TO_ALCOHOL",
"GOBP_RESPONSE_TO_BACTERIUM",
"GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS",
"GOBP_RESPONSE_TO_FLUID_SHEAR_STRESS",
"GOBP_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS",
"GOBP_RESPONSE_TO_LIPID",
"GOBP_RESPONSE_TO_LIPOPROTEIN_PARTICLE",
"GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN",
"GOBP_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_RESPONSE_TO_NUTRIENT",
"GOBP_RESPONSE_TO_NUTRIENT_LEVELS",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_PEPTIDE",
"GOBP_RESPONSE_TO_RETINOIC_ACID",
"GOBP_RESPONSE_TO_STEROL",
"GOBP_RESPONSE_TO_VITAMIN",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_REVERSE_CHOLESTEROL_TRANSPORT",
"GOBP_RHO_PROTEIN_SIGNAL_TRANSDUCTION",
"GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS",
"GOBP_SECRETION",
"GOBP_SECRETORY_GRANULE_ORGANIZATION",
"GOBP_SIGNAL_RELEASE",
"GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_SPHINGOLIPID_TRANSLOCATION",
"GOBP_STEROID_METABOLIC_PROCESS",
"GOBP_STEROL_HOMEOSTASIS",
"GOBP_STEROL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VACUOLE_ORGANIZATION",
"GOBP_VESICLE_MEDIATED_TRANSPORT",
"GOBP_VESICLE_ORGANIZATION",
"GOCC_BASAL_PART_OF_CELL",
"GOCC_BASOLATERAL_PLASMA_MEMBRANE",
"GOCC_CELL_SURFACE",
"GOCC_ENDOCYTIC_VESICLE",
"GOCC_ENDOSOME",
"GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE",
"GOCC_GOLGI_APPARATUS",
"GOCC_MEMBRANE_MICRODOMAIN",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM",
"GOCC_PHAGOCYTIC_VESICLE",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_SIDE_OF_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ALCOHOL_BINDING",
"GOMF_APOLIPOPROTEIN_A_I_BINDING",
"GOMF_APOLIPOPROTEIN_BINDING",
"GOMF_ATPASE_BINDING",
"GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_CARGO_RECEPTOR_ACTIVITY",
"GOMF_CHOLESTEROL_BINDING",
"GOMF_CHOLESTEROL_TRANSFER_ACTIVITY",
"GOMF_FLOPPASE_ACTIVITY",
"GOMF_GTPASE_BINDING",
"GOMF_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_BINDING",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_BINDING",
"GOMF_LIPID_TRANSFER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_BINDING",
"GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHATIDYLSERINE_FLOPPASE_ACTIVITY",
"GOMF_PHOSPHOLIPID_BINDING",
"GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING",
"GOMF_PROTEIN_LIPID_COMPLEX_BINDING",
"GOMF_PROTEIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_TRANSPORTER_ACTIVITY",
"GOMF_QUATERNARY_AMMONIUM_GROUP_BINDING",
"GOMF_SIGNALING_RECEPTOR_BINDING",
"GOMF_SNARE_BINDING",
"GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_STEROID_BINDING",
"GOMF_STEROL_BINDING",
"GOMF_STEROL_TRANSFER_ACTIVITY",
"GOMF_SYNTAXIN_BINDING",
"GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_ADIPOGENESIS",
"HALLMARK_BILE_ACID_METABOLISM",
"HALLMARK_INFLAMMATORY_RESPONSE",
"HALLMARK_PROTEIN_SECRETION",
"HALLMARK_TNFA_SIGNALING_VIA_NFKB",
"KEGG_ABC_TRANSPORTERS",
"MTOR_UP.V1_DN",
"NOTCH_DN.V1_DN",
"PID_RXR_VDR_PATHWAY",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_HDL_ASSEMBLY",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING",
"REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX",
"REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY",
"REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE",
"REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA",
"REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"STK33_NOMO_UP",
"STK33_UP",
"WNT_UP.V1_DN",
"WP_2Q37_COPY_NUMBER_VARIATION_SYNDROME",
"WP_CAMKK2_PATHWAY",
"WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES",
"WP_CHOLESTEROL_METABOLISM",
"WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS",
"WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS",
"WP_ENTEROCYTE_CHOLESTEROL_METABOLISM",
"WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES",
"WP_FOLATE_METABOLISM",
"WP_METABOLIC_PATHWAY_OF_LDL_HDL_AND_TG_INCLUDING_DISEASES",
"WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY",
"WP_SELENIUM_MICRONUTRIENT_NETWORK",
"WP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS",
"WP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION",
"WP_UROTENSINIIMEDIATED_SIGNALING",
"WP_VITAMIN_B12_METABOLISM"
] |
ABCA10
|
Q8WWZ4
|
ATP-binding cassette sub-family A member 10
|
Probable transporter which may play a role in macrophage lipid transport and homeostasis
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:plasma membrane",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:lipid transporter activity",
"P:lipid transport"
] |
[
"GOBP_LIPID_LOCALIZATION",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCA11P
| null | null | null |
[] |
[] |
[] |
[
"WP_VITAMIN_D_RECEPTOR_PATHWAY"
] |
ABCA12
|
Q86UK0
|
Glucosylceramide transporter ABCA12
|
Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function (PubMed:16007253, PubMed:20869849). In the meantime, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turn regulates desquamation and keratinocyte differentiation (PubMed:19179616). Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1 (By similarity). Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton (By similarity). Also involved in lung surfactant biogenesis (By similarity)
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[
"ABCA1"
] |
[
"C:cytoplasm",
"C:cytosol",
"C:epidermal lamellar body",
"C:epidermal lamellar body membrane",
"C:Golgi membrane",
"C:membrane",
"C:plasma membrane",
"C:transport vesicle membrane",
"F:ABC-type transporter activity",
"F:apolipoprotein A-I receptor binding",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled intramembrane lipid transporter activity",
"F:ATPase-coupled lipid transmembrane transporter activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:lipid transporter activity",
"F:signaling receptor binding",
"P:cellular homeostasis",
"P:ceramide metabolic process",
"P:ceramide transport",
"P:cholesterol efflux",
"P:corneocyte desquamation",
"P:establishment of skin barrier",
"P:intracellular protein transport",
"P:keratinization",
"P:lipid homeostasis",
"P:lipid transport",
"P:lung alveolus development",
"P:phospholipid efflux",
"P:positive regulation of cholesterol efflux",
"P:positive regulation of intracellular lipid transport",
"P:positive regulation of protein localization to cell surface",
"P:protein localization to plasma membrane",
"P:regulated exocytosis",
"P:regulation of insulin secretion involved in cellular response to glucose stimulus",
"P:regulation of keratinocyte differentiation",
"P:secretion by cell",
"P:surfactant homeostasis"
] |
[
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_AMIDE_TRANSPORT",
"GOBP_ANIMAL_ORGAN_MORPHOGENESIS",
"GOBP_CARBOHYDRATE_HOMEOSTASIS",
"GOBP_CELLULAR_HOMEOSTASIS",
"GOBP_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_CELL_ADHESION",
"GOBP_CELL_CELL_ADHESION",
"GOBP_CELL_CELL_SIGNALING",
"GOBP_CERAMIDE_METABOLIC_PROCESS",
"GOBP_CERAMIDE_TRANSPORT",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_DELAMINATION",
"GOBP_EPIDERMAL_CELL_DIFFERENTIATION",
"GOBP_EPIDERMIS_DEVELOPMENT",
"GOBP_EPITHELIAL_CELL_DEVELOPMENT",
"GOBP_EPITHELIAL_CELL_DIFFERENTIATION",
"GOBP_EPITHELIUM_DEVELOPMENT",
"GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_ESTABLISHMENT_OF_SKIN_BARRIER",
"GOBP_EXOCYTOSIS",
"GOBP_EXPORT_FROM_CELL",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_HORMONE_TRANSPORT",
"GOBP_INSULIN_SECRETION",
"GOBP_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS",
"GOBP_INTRACELLULAR_GLUCOSE_HOMEOSTASIS",
"GOBP_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_INTRACELLULAR_PROTEIN_TRANSPORT",
"GOBP_INTRACELLULAR_TRANSPORT",
"GOBP_KERATINIZATION",
"GOBP_KERATINOCYTE_DEVELOPMENT",
"GOBP_KERATINOCYTE_DIFFERENTIATION",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LOCALIZATION_WITHIN_MEMBRANE",
"GOBP_LUNG_ALVEOLUS_DEVELOPMENT",
"GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_CHEMICAL_HOMEOSTASIS",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS",
"GOBP_NEGATIVE_REGULATION_OF_CELL_ADHESION",
"GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PEPTIDE_TRANSPORT",
"GOBP_PHOSPHOLIPID_EFFLUX",
"GOBP_PHOSPHOLIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE",
"GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY",
"GOBP_PROTEIN_LOCALIZATION_TO_CELL_SURFACE",
"GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION",
"GOBP_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE",
"GOBP_PROTEIN_TRANSPORT",
"GOBP_REGULATED_EXOCYTOSIS",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_CELL_ADHESION",
"GOBP_REGULATION_OF_CELL_CELL_ADHESION",
"GOBP_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_REGULATION_OF_EPIDERMIS_DEVELOPMENT",
"GOBP_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_REGULATION_OF_HORMONE_LEVELS",
"GOBP_REGULATION_OF_HORMONE_SECRETION",
"GOBP_REGULATION_OF_INSULIN_SECRETION",
"GOBP_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_INTRACELLULAR_TRANSPORT",
"GOBP_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION",
"GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT",
"GOBP_REGULATION_OF_PEPTIDE_TRANSPORT",
"GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE",
"GOBP_REGULATION_OF_PROTEIN_SECRETION",
"GOBP_REGULATION_OF_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_SECRETION",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_RESPIRATORY_SYSTEM_DEVELOPMENT",
"GOBP_RESPONSE_TO_CARBOHYDRATE",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_SECRETION",
"GOBP_SIGNAL_RELEASE",
"GOBP_SKIN_DEVELOPMENT",
"GOBP_SKIN_EPIDERMIS_DEVELOPMENT",
"GOBP_SKIN_MORPHOGENESIS",
"GOBP_SPHINGOLIPID_METABOLIC_PROCESS",
"GOBP_STEROL_TRANSPORT",
"GOBP_SURFACTANT_HOMEOSTASIS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_TUBE_DEVELOPMENT",
"GOBP_VESICLE_MEDIATED_TRANSPORT",
"GOCC_GOLGI_APPARATUS",
"GOCC_GOLGI_MEMBRANE",
"GOCC_LAMELLAR_BODY",
"GOCC_SECRETORY_GRANULE",
"GOCC_SECRETORY_GRANULE_MEMBRANE",
"GOCC_SECRETORY_VESICLE",
"GOCC_TRANSPORT_VESICLE",
"GOCC_TRANSPORT_VESICLE_MEMBRANE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_APOLIPOPROTEIN_RECEPTOR_BINDING",
"GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SIGNALING_RECEPTOR_BINDING",
"GOMF_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"MEK_UP.V1_DN",
"RAF_UP.V1_DN",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCA13
|
Q86UQ4
|
ATP-binding cassette sub-family A member 13
|
May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:azurophil granule membrane",
"C:intracellular vesicle",
"C:plasma membrane",
"C:secretory granule membrane",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:lipid transporter activity",
"P:ceramide transport",
"P:lipid transport",
"P:positive regulation of cholesterol transport",
"P:positive regulation of synaptic vesicle endocytosis"
] |
[
"GOBP_AMIDE_TRANSPORT",
"GOBP_CERAMIDE_TRANSPORT",
"GOBP_ENDOCYTOSIS",
"GOBP_IMPORT_INTO_CELL",
"GOBP_LIPID_LOCALIZATION",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_ENDOCYTOSIS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_VESICLE_RECYCLING",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_PRESYNAPTIC_ENDOCYTOSIS",
"GOBP_REGULATION_OF_ENDOCYTOSIS",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_SYNAPTIC_VESICLE_ENDOCYTOSIS",
"GOBP_REGULATION_OF_SYNAPTIC_VESICLE_RECYCLING",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT",
"GOBP_STEROL_TRANSPORT",
"GOBP_SYNAPTIC_VESICLE_RECYCLING",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VESICLE_MEDIATED_TRANSPORT",
"GOBP_VESICLE_MEDIATED_TRANSPORT_IN_SYNAPSE",
"GOCC_AZUROPHIL_GRANULE",
"GOCC_AZUROPHIL_GRANULE_MEMBRANE",
"GOCC_SECRETORY_GRANULE",
"GOCC_SECRETORY_GRANULE_MEMBRANE",
"GOCC_SECRETORY_VESICLE",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_INNATE_IMMUNE_SYSTEM",
"REACTOME_NEUTROPHIL_DEGRANULATION"
] |
ABCA2
|
Q9BZC7
|
ATP-binding cassette sub-family A member 2
|
Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity)
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:ATP-binding cassette (ABC) transporter complex",
"C:cytoplasmic vesicle",
"C:endosome",
"C:endosome membrane",
"C:lysosomal membrane",
"C:lysosome",
"C:membrane",
"C:microtubule organizing center",
"C:plasma membrane",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:ceramide floppase activity",
"F:endopeptidase regulator activity",
"F:lipid transporter activity",
"F:nucleotide binding",
"P:central nervous system myelin formation",
"P:ceramide translocation",
"P:cholesterol homeostasis",
"P:ganglioside metabolic process",
"P:glycosphingolipid metabolic process",
"P:intracellular sphingolipid homeostasis",
"P:lipid metabolic process",
"P:lipid transport",
"P:locomotory behavior",
"P:negative regulation of cholesterol efflux",
"P:negative regulation of intracellular cholesterol transport",
"P:negative regulation of phospholipid biosynthetic process",
"P:negative regulation of receptor-mediated endocytosis involved in cholesterol transport",
"P:negative regulation of sphingolipid biosynthetic process",
"P:negative regulation of steroid metabolic process",
"P:positive regulation of amyloid precursor protein biosynthetic process",
"P:positive regulation of amyloid precursor protein catabolic process",
"P:positive regulation of amyloid-beta formation",
"P:positive regulation of low-density lipoprotein particle receptor catabolic process",
"P:regulation of intracellular cholesterol transport",
"P:regulation of post-translational protein modification",
"P:regulation of protein localization to cell periphery",
"P:regulation of protein localization to cell surface",
"P:regulation of steroid metabolic process",
"P:response to cholesterol",
"P:response to steroid hormone",
"P:response to xenobiotic stimulus",
"P:sphingomyelin metabolic process",
"P:sphingosine biosynthetic process",
"P:transmembrane transport",
"P:transport across blood-brain barrier"
] |
[
"CYCLIN_D1_UP.V1_UP",
"ESC_V6.5_UP_EARLY.V1_DN",
"ESC_V6.5_UP_LATE.V1_DN",
"GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS",
"GOBP_ALCOHOL_METABOLIC_PROCESS",
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_AMIDE_TRANSPORT",
"GOBP_AMYLOID_BETA_FORMATION",
"GOBP_AMYLOID_BETA_METABOLIC_PROCESS",
"GOBP_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS",
"GOBP_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS",
"GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS",
"GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS",
"GOBP_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM",
"GOBP_BEHAVIOR",
"GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS",
"GOBP_CELLULAR_HOMEOSTASIS",
"GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT",
"GOBP_CENTRAL_NERVOUS_SYSTEM_MYELIN_FORMATION",
"GOBP_CERAMIDE_METABOLIC_PROCESS",
"GOBP_CERAMIDE_TRANSPORT",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_DIOL_BIOSYNTHETIC_PROCESS",
"GOBP_DIOL_METABOLIC_PROCESS",
"GOBP_ENDOCYTOSIS",
"GOBP_ENSHEATHMENT_OF_NEURONS",
"GOBP_GANGLIOSIDE_METABOLIC_PROCESS",
"GOBP_GLIAL_CELL_DEVELOPMENT",
"GOBP_GLIAL_CELL_DIFFERENTIATION",
"GOBP_GLIOGENESIS",
"GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCOPROTEIN_METABOLIC_PROCESS",
"GOBP_GLYCOSPHINGOLIPID_METABOLIC_PROCESS",
"GOBP_GLYCOSYLATION",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_IMPORT_INTO_CELL",
"GOBP_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_INTRACELLULAR_SPHINGOLIPID_HOMEOSTASIS",
"GOBP_INTRACELLULAR_STEROL_TRANSPORT",
"GOBP_INTRACELLULAR_TRANSPORT",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LIPOSACCHARIDE_METABOLIC_PROCESS",
"GOBP_LOCOMOTORY_BEHAVIOR",
"GOBP_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_PARTICLE_METABOLIC_PROCESS",
"GOBP_MACROMOLECULE_CATABOLIC_PROCESS",
"GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_MYELIN_ASSEMBLY",
"GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_NEGATIVE_REGULATION_OF_ENDOCYTOSIS",
"GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT",
"GOBP_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_NEGATIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS",
"GOBP_NEGATIVE_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_NEGATIVE_REGULATION_OF_TRANSPORT",
"GOBP_NEUROGENESIS",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_OLIGODENDROCYTE_DEVELOPMENT",
"GOBP_OLIGODENDROCYTE_DIFFERENTIATION",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_POLYOL_BIOSYNTHETIC_PROCESS",
"GOBP_POLYOL_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_AMIDE_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_FORMATION",
"GOBP_POSITIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS",
"GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION",
"GOBP_PROTEIN_CATABOLIC_PROCESS",
"GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY",
"GOBP_PROTEIN_LOCALIZATION_TO_CELL_SURFACE",
"GOBP_RECEPTOR_CATABOLIC_PROCESS",
"GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS",
"GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS_INVOLVED_IN_CHOLESTEROL_TRANSPORT",
"GOBP_RECEPTOR_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_AMIDE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_ENDOCYTOSIS",
"GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_INTRACELLULAR_TRANSPORT",
"GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_POST_TRANSLATIONAL_PROTEIN_MODIFICATION",
"GOBP_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_PROTEIN_GLYCOSYLATION",
"GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY",
"GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE",
"GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS",
"GOBP_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS",
"GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT",
"GOBP_RESPONSE_TO_ALCOHOL",
"GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS",
"GOBP_RESPONSE_TO_HORMONE",
"GOBP_RESPONSE_TO_LIPID",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_STEROID_HORMONE",
"GOBP_RESPONSE_TO_STEROL",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_SPHINGOID_BIOSYNTHETIC_PROCESS",
"GOBP_SPHINGOID_METABOLIC_PROCESS",
"GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_SPHINGOLIPID_METABOLIC_PROCESS",
"GOBP_SPHINGOLIPID_TRANSLOCATION",
"GOBP_SPHINGOMYELIN_METABOLIC_PROCESS",
"GOBP_STEROID_BIOSYNTHETIC_PROCESS",
"GOBP_STEROID_METABOLIC_PROCESS",
"GOBP_STEROL_BIOSYNTHETIC_PROCESS",
"GOBP_STEROL_HOMEOSTASIS",
"GOBP_STEROL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM",
"GOBP_VASCULAR_TRANSPORT",
"GOBP_VESICLE_MEDIATED_TRANSPORT",
"GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX",
"GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_MICROTUBULE_CYTOSKELETON",
"GOCC_MICROTUBULE_ORGANIZING_CENTER",
"GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_TRANSPORTER_COMPLEX",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_ENDOPEPTIDASE_ACTIVITY",
"GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY",
"GOMF_ENZYME_REGULATOR_ACTIVITY",
"GOMF_FLOPPASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PEPTIDASE_ACTIVITY",
"GOMF_PEPTIDASE_REGULATOR_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"HALLMARK_CHOLESTEROL_HOMEOSTASIS",
"KEGG_ABC_TRANSPORTERS",
"KEGG_LYSOSOME",
"MTOR_UP.V1_UP",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCA3
|
Q99758
|
Phospholipid-transporting ATPase ABCA3
|
Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:27177387, PubMed:28887056, PubMed:31473345). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:25817392, PubMed:26903515, PubMed:27177387)
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:alveolar lamellar body",
"C:alveolar lamellar body membrane",
"C:cytoplasmic vesicle membrane",
"C:extracellular space",
"C:lamellar body",
"C:lamellar body membrane",
"C:late endosome",
"C:lysosomal membrane",
"C:multivesicular body membrane",
"C:plasma membrane",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:lipid transporter activity",
"F:phosphatidylcholine flippase activity",
"F:phosphatidylcholine transfer activity",
"P:lipid transport",
"P:lung development",
"P:organelle assembly",
"P:phosphatidylcholine metabolic process",
"P:phosphatidylglycerol metabolic process",
"P:phospholipid homeostasis",
"P:phospholipid transport",
"P:positive regulation of cholesterol efflux",
"P:positive regulation of phospholipid efflux",
"P:positive regulation of phospholipid transport",
"P:positive regulation of protein homooligomerization",
"P:regulation of lipid biosynthetic process",
"P:regulation of phosphatidylcholine metabolic process",
"P:response to glucocorticoid",
"P:response to xenobiotic stimulus",
"P:surfactant homeostasis",
"P:xenobiotic export from cell",
"P:xenobiotic transmembrane transport",
"P:xenobiotic transport"
] |
[
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_EXPORT_FROM_CELL",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_INTERMEMBRANE_LIPID_TRANSFER",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_CHEMICAL_HOMEOSTASIS",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS",
"GOBP_ORGANELLE_ASSEMBLY",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_EFFLUX",
"GOBP_PHOSPHOLIPID_HOMEOSTASIS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_TRANSPORT",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS",
"GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY",
"GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_PROTEIN_COMPLEX_OLIGOMERIZATION",
"GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION",
"GOBP_PROTEIN_HOMOOLIGOMERIZATION",
"GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS",
"GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION",
"GOBP_REGULATION_OF_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY",
"GOBP_REGULATION_OF_PROTEIN_OLIGOMERIZATION",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_RESPIRATORY_SYSTEM_DEVELOPMENT",
"GOBP_RESPONSE_TO_CORTICOSTEROID",
"GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS",
"GOBP_RESPONSE_TO_HORMONE",
"GOBP_RESPONSE_TO_LIPID",
"GOBP_RESPONSE_TO_STEROID_HORMONE",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_STEROL_TRANSPORT",
"GOBP_SURFACTANT_HOMEOSTASIS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_TUBE_DEVELOPMENT",
"GOBP_XENOBIOTIC_EXPORT_FROM_CELL",
"GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOCC_ALVEOLAR_LAMELLAR_BODY",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_LAMELLAR_BODY",
"GOCC_LATE_ENDOSOME",
"GOCC_LATE_ENDOSOME_MEMBRANE",
"GOCC_MULTIVESICULAR_BODY",
"GOCC_MULTIVESICULAR_BODY_MEMBRANE",
"GOCC_SECRETORY_GRANULE",
"GOCC_SECRETORY_GRANULE_MEMBRANE",
"GOCC_SECRETORY_VESICLE",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_FLIPPASE_ACTIVITY",
"GOMF_GLYCEROPHOSPHOLIPID_FLIPPASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSFER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_FLIPPASE_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_TRANSFER_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHOLIPID_TRANSFER_ACTIVITY",
"GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"HALLMARK_ESTROGEN_RESPONSE_EARLY",
"HALLMARK_ESTROGEN_RESPONSE_LATE",
"KEGG_ABC_TRANSPORTERS",
"KRAS.KIDNEY_UP.V1_DN",
"PID_ERA_GENOMIC_PATHWAY",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_DISEASES_ASSOCIATED_WITH_SURFACTANT_METABOLISM",
"REACTOME_DISEASES_OF_METABOLISM",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_SURFACTANT_METABOLISM",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCA4
|
P78363
|
Retinal-specific phospholipid-transporting ATPase ABCA4
|
Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine (N-Ret-PE) from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where 11-cis-retinylidene-phosphatidylethanolamine is then isomerized to its all-trans isomer and reduced by RDH8 to produce all-trans-retinol. This transport activity ensures that all-trans-retinal generated from photoexcitation and 11-cis-retinal not needed for the regeneration of rhodopsin and cone opsins are effectively cleared from the photoreceptors, therefore preventing their accumulation and the formation of toxic bisretinoid (PubMed:10075733, PubMed:20404325, PubMed:22735453, PubMed:23144455, PubMed:24097981, PubMed:29847635, PubMed:33375396). Displays ATPase activity in vitro in absence of retinal substrate (PubMed:33605212, PubMed:39128720, PubMed:29847635, PubMed:33375396). May display GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds (PubMed:22735453). Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP, and ATP binding and hydrolysis induce a protein conformational change that causes N-retinylidene-phosphatidylethanolamine release (By similarity)
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:cytoplasmic vesicle",
"C:endoplasmic reticulum",
"C:membrane",
"C:photoreceptor disc membrane",
"C:photoreceptor outer segment",
"C:plasma membrane",
"C:rod photoreceptor disc membrane",
"F:11-cis retinal binding",
"F:ABC-type transporter activity",
"F:all-trans retinal binding",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled intramembrane lipid transporter activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:flippase activity",
"F:GTPase activity",
"F:N-retinylidene-phosphatidylethanolamine flippase activity",
"F:phosphatidylethanolamine flippase activity",
"F:phospholipid transporter activity",
"F:retinoid binding",
"F:retinol transmembrane transporter activity",
"P:lipid transport",
"P:phospholipid transfer to membrane",
"P:phospholipid translocation",
"P:photoreceptor cell maintenance",
"P:phototransduction, visible light",
"P:retinal metabolic process",
"P:retinoid metabolic process",
"P:transmembrane transport",
"P:visual perception"
] |
[
"BMI1_DN_MEL18_DN.V1_DN",
"CRX_DN.V1_UP",
"GOBP_ALDEHYDE_METABOLIC_PROCESS",
"GOBP_DETECTION_OF_ABIOTIC_STIMULUS",
"GOBP_DETECTION_OF_LIGHT_STIMULUS",
"GOBP_DETECTION_OF_STIMULUS",
"GOBP_DETECTION_OF_VISIBLE_LIGHT",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_ISOPRENOID_METABOLIC_PROCESS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS",
"GOBP_NERVOUS_SYSTEM_PROCESS",
"GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PHOSPHOLIPID_TRANSLOCATION",
"GOBP_PHOSPHOLIPID_TRANSPORT",
"GOBP_PHOTORECEPTOR_CELL_MAINTENANCE",
"GOBP_PHOTOTRANSDUCTION",
"GOBP_PHOTOTRANSDUCTION_VISIBLE_LIGHT",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION",
"GOBP_RESPONSE_TO_ABIOTIC_STIMULUS",
"GOBP_RESPONSE_TO_LIGHT_STIMULUS",
"GOBP_RESPONSE_TO_RADIATION",
"GOBP_RETINAL_METABOLIC_PROCESS",
"GOBP_RETINA_HOMEOSTASIS",
"GOBP_SENSORY_PERCEPTION",
"GOBP_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS",
"GOBP_TERPENOID_METABOLIC_PROCESS",
"GOBP_TISSUE_HOMEOSTASIS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_9PLUS0_NON_MOTILE_CILIUM",
"GOCC_CILIUM",
"GOCC_NEURON_PROJECTION",
"GOCC_NON_MOTILE_CILIUM",
"GOCC_PHOTORECEPTOR_DISC_MEMBRANE",
"GOCC_PHOTORECEPTOR_OUTER_SEGMENT",
"GOCC_VESICLE_MEMBRANE",
"GOMF_11_CIS_RETINAL_BINDING",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ALL_TRANS_RETINAL_BINDING",
"GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_FLIPPASE_ACTIVITY",
"GOMF_GLYCEROPHOSPHOLIPID_FLIPPASE_ACTIVITY",
"GOMF_GTPASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ISOPRENOID_BINDING",
"GOMF_LIPID_BINDING",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHATIDYLETHANOLAMINE_FLIPPASE_ACTIVITY",
"GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_RETINAL_BINDING",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_VITAMIN_BINDING",
"GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"JNK_DN.V1_DN",
"KEGG_ABC_TRANSPORTERS",
"P53_DN.V1_DN",
"PKCA_DN.V1_DN",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_RETINOID_CYCLE_DISEASE_EVENTS",
"REACTOME_SENSORY_PERCEPTION",
"REACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"REACTOME_VISUAL_PHOTOTRANSDUCTION",
"SNF5_DN.V1_DN",
"VEGF_A_UP.V1_UP",
"WP_VISUAL_CYCLE"
] |
ABCA5
|
Q8WWZ7
|
Cholesterol transporter ABCA5
|
Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity)
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:Golgi membrane",
"C:late endosome",
"C:late endosome membrane",
"C:lysosomal membrane",
"C:lysosome",
"C:plasma membrane",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:lipid transporter activity",
"P:cholesterol efflux",
"P:cholesterol homeostasis",
"P:cholesterol metabolic process",
"P:high-density lipoprotein particle remodeling",
"P:lipid transport",
"P:negative regulation of macrophage derived foam cell differentiation",
"P:positive regulation of reverse cholesterol transport",
"P:regulation of cholesterol efflux",
"P:reverse cholesterol transport"
] |
[
"DCA_UP.V1_DN",
"GOBP_ALCOHOL_METABOLIC_PROCESS",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_FOAM_CELL_DIFFERENTIATION",
"GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION",
"GOBP_PROTEIN_CONTAINING_COMPLEX_REMODELING",
"GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION",
"GOBP_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS",
"GOBP_REGULATION_OF_REVERSE_CHOLESTEROL_TRANSPORT",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_REVERSE_CHOLESTEROL_TRANSPORT",
"GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_STEROID_METABOLIC_PROCESS",
"GOBP_STEROL_HOMEOSTASIS",
"GOBP_STEROL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_GOLGI_APPARATUS",
"GOCC_GOLGI_MEMBRANE",
"GOCC_LATE_ENDOSOME",
"GOCC_LATE_ENDOSOME_MEMBRANE",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCA6
|
Q8N139
|
ATP-binding cassette sub-family A member 6
|
Probable transporter which may play a role in macrophage lipid transport and homeostasis
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:Golgi membrane",
"C:nucleoplasm",
"C:plasma membrane",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:lipid transporter activity",
"P:lipid transport"
] |
[
"CSR_LATE_UP.V1_DN",
"GOBP_LIPID_LOCALIZATION",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_GOLGI_APPARATUS",
"GOCC_GOLGI_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"IL21_UP.V1_UP",
"KEGG_ABC_TRANSPORTERS",
"PTEN_DN.V1_DN",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_FOXO_MEDIATED_TRANSCRIPTION",
"REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES",
"REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCA7
|
Q8IZY2
|
Phospholipid-transporting ATPase ABCA7
|
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:12925201, PubMed:14570867, PubMed:14592415). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791)
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[
"SCRIB"
] |
[
"C:cell junction",
"C:cell surface",
"C:early endosome membrane",
"C:endoplasmic reticulum",
"C:glial cell projection",
"C:Golgi apparatus",
"C:Golgi membrane",
"C:phagocytic cup",
"C:plasma membrane",
"C:ruffle membrane",
"F:ABC-type transporter activity",
"F:apolipoprotein A-I receptor activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:floppase activity",
"F:phosphatidylcholine floppase activity",
"F:phosphatidylserine floppase activity",
"F:phospholipid transporter activity",
"P:amyloid-beta clearance by cellular catabolic process",
"P:amyloid-beta formation",
"P:apolipoprotein A-I-mediated signaling pathway",
"P:cholesterol efflux",
"P:high-density lipoprotein particle assembly",
"P:memory",
"P:negative regulation of amyloid precursor protein biosynthetic process",
"P:negative regulation of amyloid-beta formation",
"P:negative regulation of endocytosis",
"P:negative regulation of MAPK cascade",
"P:negative regulation of PERK-mediated unfolded protein response",
"P:phagocytosis",
"P:phospholipid efflux",
"P:phospholipid translocation",
"P:plasma membrane raft organization",
"P:positive regulation of amyloid-beta clearance",
"P:positive regulation of cholesterol efflux",
"P:positive regulation of engulfment of apoptotic cell",
"P:positive regulation of ERK1 and ERK2 cascade",
"P:positive regulation of phagocytosis",
"P:positive regulation of phospholipid efflux",
"P:positive regulation of protein localization to cell surface",
"P:protein localization to nucleus",
"P:regulation of amyloid precursor protein catabolic process",
"P:regulation of lipid metabolic process",
"P:visual learning"
] |
[
"AKT_UP.V1_UP",
"AKT_UP_MTOR_DN.V1_UP",
"ESC_V6.5_UP_EARLY.V1_DN",
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_AMYLOID_BETA_CLEARANCE",
"GOBP_AMYLOID_BETA_CLEARANCE_BY_CELLULAR_CATABOLIC_PROCESS",
"GOBP_AMYLOID_BETA_FORMATION",
"GOBP_AMYLOID_BETA_METABOLIC_PROCESS",
"GOBP_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS",
"GOBP_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS",
"GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS",
"GOBP_APOLIPOPROTEIN_A_I_MEDIATED_SIGNALING_PATHWAY",
"GOBP_APOPTOTIC_CELL_CLEARANCE",
"GOBP_ASSOCIATIVE_LEARNING",
"GOBP_BEHAVIOR",
"GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_CELLULAR_RESPONSE_TO_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN",
"GOBP_CELLULAR_RESPONSE_TO_UNFOLDED_PROTEIN",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_COGNITION",
"GOBP_ENDOCYTOSIS",
"GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION",
"GOBP_ENGULFMENT_OF_APOPTOTIC_CELL",
"GOBP_ERK1_AND_ERK2_CASCADE",
"GOBP_ER_NUCLEUS_SIGNALING_PATHWAY",
"GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCOPROTEIN_METABOLIC_PROCESS",
"GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY",
"GOBP_IMPORT_INTO_CELL",
"GOBP_INTEGRATED_STRESS_RESPONSE_SIGNALING",
"GOBP_LEARNING",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MAPK_CASCADE",
"GOBP_MEMBRANE_INVAGINATION",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_MEMBRANE_RAFT_ORGANIZATION",
"GOBP_MEMORY",
"GOBP_NEGATIVE_REGULATION_OF_AMIDE_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_NEGATIVE_REGULATION_OF_ENDOCYTOSIS",
"GOBP_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE",
"GOBP_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION",
"GOBP_NEGATIVE_REGULATION_OF_MAPK_CASCADE",
"GOBP_NEGATIVE_REGULATION_OF_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS",
"GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS",
"GOBP_NEGATIVE_REGULATION_OF_SIGNALING",
"GOBP_NEGATIVE_REGULATION_OF_TRANSPORT",
"GOBP_NERVOUS_SYSTEM_PROCESS",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE",
"GOBP_PHAGOCYTOSIS",
"GOBP_PHAGOCYTOSIS_ENGULFMENT",
"GOBP_PHOSPHOLIPID_EFFLUX",
"GOBP_PHOSPHOLIPID_TRANSLOCATION",
"GOBP_PHOSPHOLIPID_TRANSPORT",
"GOBP_PLASMA_MEMBRANE_ORGANIZATION",
"GOBP_PLASMA_MEMBRANE_RAFT_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_CLEARANCE",
"GOBP_POSITIVE_REGULATION_OF_APOPTOTIC_CELL_CLEARANCE",
"GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_POSITIVE_REGULATION_OF_ENDOCYTOSIS",
"GOBP_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE",
"GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE",
"GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_PHAGOCYTOSIS",
"GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE",
"GOBP_POSITIVE_REGULATION_OF_SIGNALING",
"GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION",
"GOBP_PROTEIN_LIPID_COMPLEX_ASSEMBLY",
"GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION",
"GOBP_PROTEIN_LOCALIZATION_TO_CELL_SURFACE",
"GOBP_PROTEIN_LOCALIZATION_TO_NUCLEUS",
"GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE",
"GOBP_REGULATION_OF_AMIDE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_AMYLOID_BETA_CLEARANCE",
"GOBP_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_APOPTOTIC_CELL_CLEARANCE",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS",
"GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_REGULATION_OF_ENDOCYTOSIS",
"GOBP_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE",
"GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_MEMBRANE_INVAGINATION",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION",
"GOBP_REGULATION_OF_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE",
"GOBP_REGULATION_OF_PHAGOCYTOSIS",
"GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS",
"GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE",
"GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS",
"GOBP_REGULATION_OF_RESPONSE_TO_STRESS",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT",
"GOBP_RESPONSE_TO_ABIOTIC_STIMULUS",
"GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS",
"GOBP_RESPONSE_TO_LIGHT_STIMULUS",
"GOBP_RESPONSE_TO_RADIATION",
"GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN",
"GOBP_STEROL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VESICLE_MEDIATED_TRANSPORT",
"GOBP_VISUAL_BEHAVIOR",
"GOCC_CELL_LEADING_EDGE",
"GOCC_CELL_PROJECTION_MEMBRANE",
"GOCC_CELL_SURFACE",
"GOCC_EARLY_ENDOSOME",
"GOCC_EARLY_ENDOSOME_MEMBRANE",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_GLIAL_CELL_PROJECTION",
"GOCC_GOLGI_APPARATUS",
"GOCC_GOLGI_MEMBRANE",
"GOCC_LEADING_EDGE_MEMBRANE",
"GOCC_PHAGOCYTIC_CUP",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_RUFFLE",
"GOCC_RUFFLE_MEMBRANE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_CARGO_RECEPTOR_ACTIVITY",
"GOMF_FLOPPASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHATIDYLSERINE_FLOPPASE_ACTIVITY",
"GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCA8
|
O94911
|
ABC-type organic anion transporter ABCA8
|
Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate (PubMed:12379217). In vitro, also imports ochratoxin A (PubMed:12379217). Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes (PubMed:23560799)
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:basolateral plasma membrane",
"C:endoplasmic reticulum",
"C:plasma membrane",
"F:ABC-type transporter activity",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:lipid transporter activity",
"P:cholesterol efflux",
"P:cholesterol transport",
"P:lipid transport",
"P:positive regulation of cholesterol efflux",
"P:regulation of cholesterol efflux",
"P:sphingomyelin biosynthetic process",
"P:transmembrane transport",
"P:xenobiotic transmembrane transport",
"P:xenobiotic transport"
] |
[
"ATF2_S_UP.V1_DN",
"ATF2_UP.V1_DN",
"ATM_DN.V1_UP",
"GOBP_AMIDE_BIOSYNTHETIC_PROCESS",
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_SPHINGOLIPID_METABOLIC_PROCESS",
"GOBP_SPHINGOMYELIN_BIOSYNTHETIC_PROCESS",
"GOBP_SPHINGOMYELIN_METABOLIC_PROCESS",
"GOBP_STEROL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOCC_BASAL_PART_OF_CELL",
"GOCC_BASOLATERAL_PLASMA_MEMBRANE",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"KEGG_ABC_TRANSPORTERS",
"PGF_UP.V1_UP",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCA9
|
Q8IUA7
|
ATP-binding cassette sub-family A member 9
|
Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:plasma membrane",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:lipid transporter activity",
"P:lipid transport"
] |
[
"GOBP_LIPID_LOCALIZATION",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCB1
|
P08183
|
ATP-dependent translocase ABCB1
|
Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[
"LAPTM4B",
"RNF2"
] |
[
"C:apical plasma membrane",
"C:brush border membrane",
"C:cell surface",
"C:cytoplasm",
"C:external side of apical plasma membrane",
"C:extracellular exosome",
"C:membrane",
"C:plasma membrane",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:carboxylic acid transmembrane transporter activity",
"F:ceramide floppase activity",
"F:efflux transmembrane transporter activity",
"F:floppase activity",
"F:phosphatidylcholine floppase activity",
"F:phosphatidylethanolamine flippase activity",
"F:phosphatidylethanolamine floppase activity",
"F:transmembrane transporter activity",
"F:ubiquitin protein ligase binding",
"F:xenobiotic transmembrane transporter activity",
"P:carboxylic acid transmembrane transport",
"P:cellular hyperosmotic salinity response",
"P:cellular response to alkaloid",
"P:cellular response to antibiotic",
"P:cellular response to borneol",
"P:cellular response to dexamethasone stimulus",
"P:cellular response to estradiol stimulus",
"P:cellular response to external biotic stimulus",
"P:cellular response to L-glutamate",
"P:cellular response to lipopolysaccharide",
"P:cellular response to mycotoxin",
"P:cellular response to nonylphenol",
"P:cellular response to tumor necrosis factor",
"P:ceramide translocation",
"P:circadian rhythm",
"P:daunorubicin transport",
"P:establishment of blood-brain barrier",
"P:establishment of blood-retinal barrier",
"P:export across plasma membrane",
"P:female pregnancy",
"P:G2/M transition of mitotic cell cycle",
"P:hormone transport",
"P:intestinal absorption",
"P:lactation",
"P:maintenance of blood-brain barrier",
"P:negative regulation of sensory perception of pain",
"P:phospholipid translocation",
"P:placenta development",
"P:positive regulation of establishment of Sertoli cell barrier",
"P:positive regulation of response to drug",
"P:protein localization to bicellular tight junction",
"P:regulation of chloride transport",
"P:regulation of intestinal absorption",
"P:response to alcohol",
"P:response to antineoplastic agent",
"P:response to cadmium ion",
"P:response to codeine",
"P:response to cyclosporin A",
"P:response to glucagon",
"P:response to glycoside",
"P:response to hypoxia",
"P:response to progesterone",
"P:response to quercetin",
"P:response to thyroxine",
"P:response to vitamin A",
"P:response to vitamin D",
"P:response to xenobiotic stimulus",
"P:stem cell proliferation",
"P:terpenoid transport",
"P:transepithelial transport",
"P:transmembrane transport",
"P:transport across blood-brain barrier",
"P:xenobiotic detoxification by transmembrane export across the plasma membrane",
"P:xenobiotic metabolic process",
"P:xenobiotic transport across blood-brain barrier"
] |
[
"BCAT.100_UP.V1_UP",
"BCAT_GDS748_UP",
"BIOCARTA_MRP_PATHWAY",
"BIOCARTA_NUCLEARRS_PATHWAY",
"BIOCARTA_P53HYPOXIA_PATHWAY",
"GOBP_AMIDE_TRANSPORT",
"GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS",
"GOBP_BODY_FLUID_SECRETION",
"GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT",
"GOBP_CELLULAR_HYPEROSMOTIC_RESPONSE",
"GOBP_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_ACID_CHEMICAL",
"GOBP_CELLULAR_RESPONSE_TO_ALKALOID",
"GOBP_CELLULAR_RESPONSE_TO_ANTIBIOTIC",
"GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_GLUCOCORTICOID_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_KETONE",
"GOBP_CELLULAR_RESPONSE_TO_LIPID",
"GOBP_CELLULAR_RESPONSE_TO_L_GLUTAMATE",
"GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN",
"GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_CELLULAR_RESPONSE_TO_SALT_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE",
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_CELL_CYCLE",
"GOBP_CELL_CYCLE_G2_M_PHASE_TRANSITION",
"GOBP_CELL_CYCLE_PHASE_TRANSITION",
"GOBP_CELL_CYCLE_PROCESS",
"GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT",
"GOBP_CERAMIDE_TRANSPORT",
"GOBP_CHLORIDE_TRANSPORT",
"GOBP_CIRCADIAN_RHYTHM",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_DETOXIFICATION",
"GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION",
"GOBP_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS",
"GOBP_DIGESTION",
"GOBP_DIGESTIVE_SYSTEM_PROCESS",
"GOBP_EPITHELIAL_CELL_DEVELOPMENT",
"GOBP_EPITHELIAL_CELL_DIFFERENTIATION",
"GOBP_EPITHELIUM_DEVELOPMENT",
"GOBP_ESTABLISHMENT_OF_BLOOD_BRAIN_BARRIER",
"GOBP_ESTABLISHMENT_OF_BLOOD_RETINAL_BARRIER",
"GOBP_ESTABLISHMENT_OF_SERTOLI_CELL_BARRIER",
"GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_EXPORT_FROM_CELL",
"GOBP_GLAND_DEVELOPMENT",
"GOBP_GLYCOSIDE_TRANSPORT",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_HORMONE_TRANSPORT",
"GOBP_HYPEROSMOTIC_RESPONSE",
"GOBP_HYPEROSMOTIC_SALINITY_RESPONSE",
"GOBP_INORGANIC_ANION_TRANSPORT",
"GOBP_INTESTINAL_ABSORPTION",
"GOBP_LACTATION",
"GOBP_LIPID_LOCALIZATION",
"GOBP_MAINTENANCE_OF_BLOOD_BRAIN_BARRIER",
"GOBP_MALE_SEX_DIFFERENTIATION",
"GOBP_MAMMARY_GLAND_DEVELOPMENT",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_MITOTIC_CELL_CYCLE",
"GOBP_MITOTIC_CELL_CYCLE_PHASE_TRANSITION",
"GOBP_MITOTIC_CELL_CYCLE_PROCESS",
"GOBP_MONOATOMIC_ANION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS",
"GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_PROCESS",
"GOBP_NERVOUS_SYSTEM_PROCESS",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANIC_CATION_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PHOSPHOLIPID_TRANSLOCATION",
"GOBP_PHOSPHOLIPID_TRANSPORT",
"GOBP_PLACENTA_DEVELOPMENT",
"GOBP_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT",
"GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS",
"GOBP_PROTEIN_LOCALIZATION_TO_BICELLULAR_TIGHT_JUNCTION",
"GOBP_PROTEIN_LOCALIZATION_TO_CELL_CELL_JUNCTION",
"GOBP_PROTEIN_LOCALIZATION_TO_CELL_JUNCTION",
"GOBP_REGULATION_OF_BODY_FLUID_LEVELS",
"GOBP_REGULATION_OF_CELL_DEVELOPMENT",
"GOBP_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_CHLORIDE_TRANSPORT",
"GOBP_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_HORMONE_LEVELS",
"GOBP_REGULATION_OF_INTESTINAL_ABSORPTION",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION",
"GOBP_REGULATION_OF_MONOATOMIC_ANION_TRANSPORT",
"GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSPORT",
"GOBP_REGULATION_OF_NERVOUS_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_REPRODUCTIVE_PROCESS",
"GOBP_REGULATION_OF_RESPONSE_TO_DRUG",
"GOBP_REGULATION_OF_SENSORY_PERCEPTION",
"GOBP_REGULATION_OF_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_REPRODUCTIVE_PROCESS",
"GOBP_REPRODUCTIVE_SYSTEM_DEVELOPMENT",
"GOBP_RESPONSE_TO_ABIOTIC_STIMULUS",
"GOBP_RESPONSE_TO_ACID_CHEMICAL",
"GOBP_RESPONSE_TO_ALCOHOL",
"GOBP_RESPONSE_TO_ALKALOID",
"GOBP_RESPONSE_TO_ANTIBIOTIC",
"GOBP_RESPONSE_TO_BACTERIUM",
"GOBP_RESPONSE_TO_CADMIUM_ION",
"GOBP_RESPONSE_TO_CORTICOSTEROID",
"GOBP_RESPONSE_TO_DEXAMETHASONE",
"GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS",
"GOBP_RESPONSE_TO_ESTRADIOL",
"GOBP_RESPONSE_TO_GLUCAGON",
"GOBP_RESPONSE_TO_GLYCOSIDE",
"GOBP_RESPONSE_TO_HORMONE",
"GOBP_RESPONSE_TO_ISOQUINOLINE_ALKALOID",
"GOBP_RESPONSE_TO_KETONE",
"GOBP_RESPONSE_TO_LIPID",
"GOBP_RESPONSE_TO_L_GLUTAMATE",
"GOBP_RESPONSE_TO_L_PHENYLALANINE_DERIVATIVE",
"GOBP_RESPONSE_TO_METAL_ION",
"GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN",
"GOBP_RESPONSE_TO_MYCOTOXIN",
"GOBP_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_RESPONSE_TO_NUTRIENT",
"GOBP_RESPONSE_TO_NUTRIENT_LEVELS",
"GOBP_RESPONSE_TO_OSMOTIC_STRESS",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_OXYGEN_LEVELS",
"GOBP_RESPONSE_TO_PEPTIDE",
"GOBP_RESPONSE_TO_PEPTIDE_HORMONE",
"GOBP_RESPONSE_TO_PROGESTERONE",
"GOBP_RESPONSE_TO_SALT_STRESS",
"GOBP_RESPONSE_TO_STEROID_HORMONE",
"GOBP_RESPONSE_TO_THYROID_HORMONE",
"GOBP_RESPONSE_TO_THYROXINE",
"GOBP_RESPONSE_TO_TOXIC_SUBSTANCE",
"GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR",
"GOBP_RESPONSE_TO_VITAMIN",
"GOBP_RESPONSE_TO_VITAMIN_A",
"GOBP_RESPONSE_TO_VITAMIN_D",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_RHYTHMIC_PROCESS",
"GOBP_SECRETION",
"GOBP_SENSORY_PERCEPTION",
"GOBP_SENSORY_PERCEPTION_OF_PAIN",
"GOBP_SERTOLI_CELL_DEVELOPMENT",
"GOBP_SERTOLI_CELL_DIFFERENTIATION",
"GOBP_SEX_DIFFERENTIATION",
"GOBP_SPHINGOLIPID_TRANSLOCATION",
"GOBP_STEM_CELL_PROLIFERATION",
"GOBP_TISSUE_HOMEOSTASIS",
"GOBP_TRANSEPITHELIAL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM",
"GOBP_VASCULAR_TRANSPORT",
"GOBP_XENOBIOTIC_EXPORT_FROM_CELL",
"GOBP_XENOBIOTIC_METABOLIC_PROCESS",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_BRUSH_BORDER",
"GOCC_BRUSH_BORDER_MEMBRANE",
"GOCC_CELL_PROJECTION_MEMBRANE",
"GOCC_CELL_SURFACE",
"GOCC_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS",
"GOCC_EXTERNAL_SIDE_OF_APICAL_PLASMA_MEMBRANE",
"GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_SIDE_OF_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_FLIPPASE_ACTIVITY",
"GOMF_FLOPPASE_ACTIVITY",
"GOMF_GLYCEROPHOSPHOLIPID_FLIPPASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHATIDYLETHANOLAMINE_FLIPPASE_ACTIVITY",
"GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_IL2_STAT5_SIGNALING",
"HALLMARK_KRAS_SIGNALING_UP",
"HALLMARK_PEROXISOME",
"HALLMARK_UV_RESPONSE_UP",
"KEGG_ABC_TRANSPORTERS",
"KEGG_MEDICUS_VARIANT_CDX2_OVEREXPRESSION_TO_TRANSCRIPTIONAL_ACTIVATION",
"KRAS.300_UP.V1_DN",
"KRAS.50_UP.V1_DN",
"KRAS.600_UP.V1_DN",
"KRAS.BREAST_UP.V1_DN",
"KRAS.LUNG_UP.V1_UP",
"KRAS.PROSTATE_UP.V1_DN",
"PID_HIF1_TFPATHWAY",
"REACTOME_ABACAVIR_ADME",
"REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ATORVASTATIN_ADME",
"REACTOME_DRUG_ADME",
"REACTOME_PREDNISONE_ADME",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_ALLOGRAFT_REJECTION",
"WP_CODEINE_AND_MORPHINE_METABOLISM",
"WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY",
"WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT",
"WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY",
"WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS",
"WP_IMATINIB_AND_CHRONIC_MYELOID_LEUKEMIA",
"WP_LNCRNAMEDIATED_MECHANISMS_OF_THERAPEUTIC_RESISTANCE",
"WP_MALE_INFERTILITY",
"WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY",
"WP_NUCLEAR_RECEPTORS_METAPATHWAY",
"WP_PREGNANE_X_RECEPTOR_PATHWAY",
"WP_PROXIMAL_TUBULE_TRANSPORT",
"WP_VITAMIN_D_RECEPTOR_PATHWAY"
] |
ABCB10
|
Q9NRK6
|
ATP-binding cassette sub-family B member 10, mitochondrial
|
ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed:22085049, PubMed:28315685, PubMed:28808058, PubMed:34011630, PubMed:37041204). Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX) (PubMed:22085049, PubMed:28808058). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37 (By similarity). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685)
|
[
"ABC transmembrane type-1",
"ABC transporter"
] |
[
"FECH"
] |
[
"C:mitochondrial inner membrane",
"C:mitochondrial membrane",
"C:mitochondrion",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:metal ion binding",
"F:protein homodimerization activity",
"P:erythrocyte development",
"P:export from the mitochondrion",
"P:heme biosynthetic process",
"P:mitochondrial transport",
"P:mitochondrial unfolded protein response",
"P:positive regulation of erythrocyte differentiation",
"P:positive regulation of heme biosynthetic process",
"P:positive regulation of hemoglobin biosynthetic process"
] |
[
"GCNP_SHH_UP_EARLY.V1_UP",
"GOBP_CELLULAR_RESPONSE_TO_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN",
"GOBP_CELLULAR_RESPONSE_TO_UNFOLDED_PROTEIN",
"GOBP_ERYTHROCYTE_DEVELOPMENT",
"GOBP_ERYTHROCYTE_HOMEOSTASIS",
"GOBP_HEMOGLOBIN_BIOSYNTHETIC_PROCESS",
"GOBP_HEMOGLOBIN_METABOLIC_PROCESS",
"GOBP_HEMOPOIESIS",
"GOBP_HOMEOSTASIS_OF_NUMBER_OF_CELLS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT",
"GOBP_MITOCHONDRIAL_TRANSPORT",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS",
"GOBP_MYELOID_CELL_DEVELOPMENT",
"GOBP_MYELOID_CELL_DIFFERENTIATION",
"GOBP_MYELOID_CELL_HOMEOSTASIS",
"GOBP_PIGMENT_BIOSYNTHETIC_PROCESS",
"GOBP_PIGMENT_METABOLIC_PROCESS",
"GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION",
"GOBP_POSITIVE_REGULATION_OF_HEMOGLOBIN_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_CELL_DEVELOPMENT",
"GOBP_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION",
"GOBP_REGULATION_OF_HEMOGLOBIN_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_HEMOPOIESIS",
"GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT",
"GOBP_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_TETRAPYRROLE_METABOLIC_PROCESS",
"GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN",
"GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS",
"GOBP_TETRAPYRROLE_METABOLIC_PROCESS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_MITOCHONDRIAL_ENVELOPE",
"GOCC_MITOCHONDRION",
"GOCC_ORGANELLE_ENVELOPE",
"GOCC_ORGANELLE_INNER_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"VEGF_A_UP.V1_UP"
] |
ABCB11
|
O95342
|
Bile salt export pump
|
Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:15791618, PubMed:16332456, PubMed:18985798, PubMed:19228692, PubMed:20010382, PubMed:20398791, PubMed:22262466, PubMed:24711118, PubMed:29507376, PubMed:32203132). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[
"DDIT4L"
] |
[
"C:apical plasma membrane",
"C:cell surface",
"C:endosome",
"C:extracellular exosome",
"C:intercellular canaliculus",
"C:intracellular canaliculus",
"C:plasma membrane",
"C:recycling endosome",
"C:recycling endosome membrane",
"F:ABC-type bile acid transporter activity",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:bile acid transmembrane transporter activity",
"F:canalicular bile acid transmembrane transporter activity",
"P:bile acid and bile salt transport",
"P:bile acid biosynthetic process",
"P:bile acid metabolic process",
"P:canalicular bile acid transport",
"P:cholesterol homeostasis",
"P:fatty acid metabolic process",
"P:lipid homeostasis",
"P:phospholipid homeostasis",
"P:positive regulation of bile acid secretion",
"P:protein ubiquitination",
"P:regulation of bile acid metabolic process",
"P:regulation of fatty acid beta-oxidation",
"P:transmembrane transport",
"P:xenobiotic export from cell",
"P:xenobiotic metabolic process",
"P:xenobiotic transmembrane transport"
] |
[
"BIOCARTA_MRP_PATHWAY",
"BIOCARTA_NUCLEARRS_PATHWAY",
"GOBP_ACID_SECRETION",
"GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT",
"GOBP_BILE_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_BILE_ACID_METABOLIC_PROCESS",
"GOBP_BILE_ACID_SECRETION",
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_EXPORT_FROM_CELL",
"GOBP_FATTY_ACID_BETA_OXIDATION",
"GOBP_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_KETONE_METABOLIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LIPID_MODIFICATION",
"GOBP_LIPID_OXIDATION",
"GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_PHOSPHOLIPID_HOMEOSTASIS",
"GOBP_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION",
"GOBP_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION",
"GOBP_REGULATION_OF_BILE_ACID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_BILE_ACID_SECRETION",
"GOBP_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_FATTY_ACID_BETA_OXIDATION",
"GOBP_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_FATTY_ACID_OXIDATION",
"GOBP_REGULATION_OF_KETONE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_ORGANIC_ACID_TRANSPORT",
"GOBP_REGULATION_OF_SECRETION",
"GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_SECRETION",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_STEROID_METABOLIC_PROCESS",
"GOBP_STEROL_HOMEOSTASIS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_EXPORT_FROM_CELL",
"GOBP_XENOBIOTIC_METABOLIC_PROCESS",
"GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOCC_ANCHORING_JUNCTION",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_BASAL_PART_OF_CELL",
"GOCC_BASOLATERAL_PLASMA_MEMBRANE",
"GOCC_CELL_CELL_JUNCTION",
"GOCC_CELL_SURFACE",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_INTERCELLULAR_CANALICULUS",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_RECYCLING_ENDOSOME",
"GOCC_RECYCLING_ENDOSOME_MEMBRANE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_KRAS_SIGNALING_DN",
"IL21_UP.V1_UP",
"KEGG_ABC_TRANSPORTERS",
"KRAS.600_UP.V1_DN",
"KRAS.KIDNEY_UP.V1_DN",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_METABOLISM_OF_STEROIDS",
"REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS",
"REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS",
"REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL",
"WP_BILE_ACID_SYNTHESIS_AND_ENTEROHEPATIC_CIRCULATION",
"WP_CHOLESTASIS",
"WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES",
"WP_CHOLESTEROL_METABOLISM",
"WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT",
"WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY",
"WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS",
"WP_FARNESOID_X_RECEPTOR_PATHWAY",
"WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY",
"WP_NUCLEAR_RECEPTORS_METAPATHWAY"
] |
ABCB4
|
P21439
|
Phosphatidylcholine translocator ABCB4
|
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:17523162, PubMed:21820390, PubMed:23468132, PubMed:24594635, PubMed:24723470, PubMed:24806754, PubMed:31873305, PubMed:7957936, PubMed:8898203, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:28012258, PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[] |
[
"C:apical plasma membrane",
"C:clathrin-coated vesicle",
"C:cytoplasm",
"C:cytosol",
"C:extracellular exosome",
"C:focal adhesion",
"C:intercellular canaliculus",
"C:membrane",
"C:membrane raft",
"C:nucleoplasm",
"C:plasma membrane",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:phosphatidylcholine floppase activity",
"F:phospholipid transporter activity",
"P:bile acid secretion",
"P:cellular response to bile acid",
"P:lipid homeostasis",
"P:lipid metabolic process",
"P:phospholipid translocation",
"P:positive regulation of cholesterol transport",
"P:positive regulation of phospholipid translocation",
"P:positive regulation of phospholipid transport",
"P:response to fenofibrate",
"P:transmembrane transport"
] |
[
"BIOCARTA_MRP_PATHWAY",
"BIOCARTA_NUCLEARRS_PATHWAY",
"CTIP_DN.V1_DN",
"GOBP_ACID_SECRETION",
"GOBP_AMIDE_TRANSPORT",
"GOBP_BILE_ACID_SECRETION",
"GOBP_CELLULAR_RESPONSE_TO_LIPID",
"GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_CERAMIDE_TRANSPORT",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PHOSPHOLIPID_TRANSLOCATION",
"GOBP_PHOSPHOLIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION",
"GOBP_REGULATION_OF_PHOSPHOLIPID_TRANSLOCATION",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_RESPONSE_TO_BILE_ACID",
"GOBP_RESPONSE_TO_ETHER",
"GOBP_RESPONSE_TO_KETONE",
"GOBP_RESPONSE_TO_LIPID",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_SECRETION",
"GOBP_SPHINGOLIPID_TRANSLOCATION",
"GOBP_STEROL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_ANCHORING_JUNCTION",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_CELL_CELL_JUNCTION",
"GOCC_CELL_SUBSTRATE_JUNCTION",
"GOCC_CLATHRIN_COATED_VESICLE",
"GOCC_COATED_VESICLE",
"GOCC_INTERCELLULAR_CANALICULUS",
"GOCC_MEMBRANE_MICRODOMAIN",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_FLOPPASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_PEROXISOME",
"JAK2_DN.V1_UP",
"KEGG_ABC_TRANSPORTERS",
"NRL_DN.V1_DN",
"PRC1_BMI_UP.V1_UP",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_CHOLESTASIS",
"WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT",
"WP_FARNESOID_X_RECEPTOR_PATHWAY",
"WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY",
"WP_NUCLEAR_RECEPTORS_METAPATHWAY"
] |
ABCB5
|
Q2M3G0
|
ATP-binding cassette sub-family B member 5
|
Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:15205344, PubMed:15899824, PubMed:22306008). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[] |
[
"C:apical plasma membrane",
"C:plasma membrane",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:efflux transmembrane transporter activity",
"P:cell differentiation",
"P:eye development",
"P:regulation of membrane potential",
"P:transmembrane transport"
] |
[
"GOBP_REGULATION_OF_MEMBRANE_POTENTIAL",
"GOBP_SENSORY_ORGAN_DEVELOPMENT",
"GOBP_SENSORY_SYSTEM_DEVELOPMENT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCB6
|
Q9NP58
|
ATP-binding cassette sub-family B member 6
|
ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:17661442, PubMed:23792964, PubMed:27507172, PubMed:33007128). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:10837493, PubMed:17006453, PubMed:23792964, PubMed:33007128). May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (PubMed:29940187). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (PubMed:21266531, PubMed:25202056, PubMed:31053883). In addition may play a role in the transition metal homeostasis (By similarity)
|
[
"ABC transmembrane type-1",
"ABC transporter"
] |
[] |
[
"C:ATP-binding cassette (ABC) transporter complex",
"C:cytosol",
"C:early endosome membrane",
"C:endolysosome membrane",
"C:endoplasmic reticulum",
"C:endoplasmic reticulum membrane",
"C:endosome",
"C:extracellular exosome",
"C:Golgi apparatus",
"C:Golgi membrane",
"C:lysosomal membrane",
"C:melanosome membrane",
"C:mitochondrial envelope",
"C:mitochondrial outer membrane",
"C:mitochondrion",
"C:multivesicular body membrane",
"C:nucleoplasm",
"C:plasma membrane",
"C:sperm midpiece",
"C:sperm principal piece",
"C:vacuolar membrane",
"F:ABC-type heme transporter activity",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:efflux transmembrane transporter activity",
"F:heme binding",
"F:tetrapyrrole binding",
"P:brain development",
"P:cellular detoxification of cadmium ion",
"P:heme metabolic process",
"P:heme transmembrane transport",
"P:heme transport",
"P:intracellular copper ion homeostasis",
"P:intracellular iron ion homeostasis",
"P:melanosome assembly",
"P:porphyrin-containing compound biosynthetic process",
"P:porphyrin-containing compound metabolic process",
"P:skin development",
"P:tetrapyrrole metabolic process",
"P:transmembrane transport"
] |
[
"GOBP_CELLULAR_HOMEOSTASIS",
"GOBP_CELLULAR_PIGMENTATION",
"GOBP_CELLULAR_RESPONSE_TO_CADMIUM_ION",
"GOBP_CELLULAR_RESPONSE_TO_METAL_ION",
"GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE",
"GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_COPPER_ION_HOMEOSTASIS",
"GOBP_DETOXIFICATION",
"GOBP_DETOXIFICATION_OF_CADMIUM_ION",
"GOBP_DETOXIFICATION_OF_INORGANIC_COMPOUND",
"GOBP_HEAD_DEVELOPMENT",
"GOBP_HEME_B_METABOLIC_PROCESS",
"GOBP_HEME_TRANSPORT",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_INORGANIC_ION_HOMEOSTASIS",
"GOBP_INTRACELLULAR_COPPER_ION_HOMEOSTASIS",
"GOBP_INTRACELLULAR_IRON_ION_HOMEOSTASIS",
"GOBP_INTRACELLULAR_MONOATOMIC_ION_HOMEOSTASIS",
"GOBP_IRON_COORDINATION_ENTITY_TRANSPORT",
"GOBP_IRON_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_IRON_ION_TRANSPORT",
"GOBP_MELANOSOME_ASSEMBLY",
"GOBP_METAL_ION_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSPORT",
"GOBP_MONOATOMIC_ION_HOMEOSTASIS",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_ORGANELLE_ASSEMBLY",
"GOBP_PIGMENTATION",
"GOBP_PIGMENT_BIOSYNTHETIC_PROCESS",
"GOBP_PIGMENT_GRANULE_ORGANIZATION",
"GOBP_PIGMENT_METABOLIC_PROCESS",
"GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_RESPONSE_TO_CADMIUM_ION",
"GOBP_RESPONSE_TO_METAL_ION",
"GOBP_RESPONSE_TO_TOXIC_SUBSTANCE",
"GOBP_SKIN_DEVELOPMENT",
"GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS",
"GOBP_TETRAPYRROLE_METABOLIC_PROCESS",
"GOBP_TRANSITION_METAL_ION_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VESICLE_ORGANIZATION",
"GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX",
"GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX",
"GOCC_CHITOSOME",
"GOCC_EARLY_ENDOSOME",
"GOCC_EARLY_ENDOSOME_MEMBRANE",
"GOCC_ENDOLYSOSOME",
"GOCC_ENDOLYSOSOME_MEMBRANE",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_GOLGI_APPARATUS",
"GOCC_GOLGI_MEMBRANE",
"GOCC_LATE_ENDOSOME",
"GOCC_LATE_ENDOSOME_MEMBRANE",
"GOCC_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_MITOCHONDRIAL_ENVELOPE",
"GOCC_MITOCHONDRION",
"GOCC_MULTIVESICULAR_BODY",
"GOCC_MULTIVESICULAR_BODY_MEMBRANE",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_ENVELOPE",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOCC_OUTER_MEMBRANE",
"GOCC_PIGMENT_GRANULE",
"GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_TRANSPORTER_COMPLEX",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HEME_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TETRAPYRROLE_BINDING",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_GLYCOLYSIS",
"HALLMARK_HEME_METABOLISM",
"KEGG_ABC_TRANSPORTERS",
"NFE2L2.V2",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCB7
|
O75027
|
Iron-sulfur clusters transporter ABCB7, mitochondrial
|
Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:10196363, PubMed:17192393, PubMed:33157103). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity)
|
[
"ABC transmembrane type-1",
"ABC transporter"
] |
[
"ABCB7",
"FECH"
] |
[
"C:mitochondrial inner membrane",
"C:mitochondrion",
"F:ABC-type iron-sulfur cluster transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:heme transmembrane transporter activity",
"F:identical protein binding",
"F:protein homodimerization activity",
"P:intracellular iron ion homeostasis",
"P:iron ion transmembrane transport",
"P:iron-sulfur cluster assembly",
"P:iron-sulfur cluster export from the mitochondrion",
"P:negative regulation of reactive oxygen species biosynthetic process",
"P:positive regulation of heme biosynthetic process",
"P:positive regulation of iron-sulfur cluster assembly",
"P:transmembrane transport"
] |
[
"GOBP_CELLULAR_HOMEOSTASIS",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_HEME_TRANSPORT",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_INORGANIC_ION_HOMEOSTASIS",
"GOBP_INTRACELLULAR_IRON_ION_HOMEOSTASIS",
"GOBP_INTRACELLULAR_MONOATOMIC_ION_HOMEOSTASIS",
"GOBP_IRON_COORDINATION_ENTITY_TRANSPORT",
"GOBP_IRON_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_IRON_ION_TRANSPORT",
"GOBP_METALLO_SULFUR_CLUSTER_ASSEMBLY",
"GOBP_METAL_ION_TRANSPORT",
"GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT",
"GOBP_MITOCHONDRIAL_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSPORT",
"GOBP_MONOATOMIC_ION_HOMEOSTASIS",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_PIGMENT_BIOSYNTHETIC_PROCESS",
"GOBP_PIGMENT_METABOLIC_PROCESS",
"GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS",
"GOBP_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS",
"GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_TETRAPYRROLE_METABOLIC_PROCESS",
"GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS",
"GOBP_TETRAPYRROLE_METABOLIC_PROCESS",
"GOBP_TRANSITION_METAL_ION_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_MITOCHONDRIAL_ENVELOPE",
"GOCC_MITOCHONDRION",
"GOCC_ORGANELLE_ENVELOPE",
"GOCC_ORGANELLE_INNER_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HEME_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_OXIDATIVE_PHOSPHORYLATION",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_CYTOSOLIC_IRON_SULFUR_CLUSTER_ASSEMBLY",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_IRONSULFUR_CLUSTER_BIOGENESIS"
] |
ABCB8
|
Q9NUT2
|
Mitochondrial potassium channel ATP-binding subunit
|
ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane (PubMed:31435016). An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (PubMed:31435016). Plays a role in mitochondrial iron transport (PubMed:30623799). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity)
|
[
"ABC transmembrane type-1",
"ABC transporter"
] |
[
"CCDC51"
] |
[
"C:ATP-binding cassette (ABC) transporter complex",
"C:membrane",
"C:mitochondrial ATP-gated potassium channel complex",
"C:mitochondrial inner membrane",
"C:mitochondrial membrane",
"C:mitochondrion",
"C:nucleolus",
"C:nucleoplasm",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"P:cell volume homeostasis",
"P:mitochondrial potassium ion transmembrane transport",
"P:potassium ion transmembrane transport",
"P:transmembrane transport"
] |
[
"GOBP_CELLULAR_HOMEOSTASIS",
"GOBP_CELL_VOLUME_HOMEOSTASIS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_METAL_ION_TRANSPORT",
"GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT",
"GOBP_MITOCHONDRIAL_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_POTASSIUM_ION_TRANSPORT",
"GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE",
"GOBP_REGULATION_OF_CELLULAR_COMPONENT_SIZE",
"GOBP_REGULATION_OF_CELL_SIZE",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX",
"GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX",
"GOCC_CATION_CHANNEL_COMPLEX",
"GOCC_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_MITOCHONDRIAL_ENVELOPE",
"GOCC_MITOCHONDRION",
"GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX",
"GOCC_NUCLEOLUS",
"GOCC_ORGANELLE_ENVELOPE",
"GOCC_ORGANELLE_INNER_MEMBRANE",
"GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_POTASSIUM_CHANNEL_COMPLEX",
"GOCC_TRANSPORTER_COMPLEX",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_ADIPOGENESIS",
"KEGG_ABC_TRANSPORTERS",
"KRAS.AMP.LUNG_UP.V1_DN",
"PRC2_EED_DN.V1_DN",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCB9
|
Q9NP78
|
ABC-type oligopeptide transporter ABCB9
|
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation (PubMed:15863492, PubMed:17977821, PubMed:18434309, PubMed:22641697, PubMed:25646430, PubMed:30353140, PubMed:30877195, PubMed:31417173). Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers (PubMed:15863492, PubMed:25646430). Binds and transports smaller and larger peptides with the same affinity (PubMed:31417173). Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (PubMed:15863492, PubMed:17977821, PubMed:18434309)
|
[
"ABC transmembrane type-1",
"ABC transporter"
] |
[] |
[
"C:endoplasmic reticulum membrane",
"C:lysosomal membrane",
"C:lysosome",
"C:membrane",
"F:ABC-type oligopeptide transporter activity",
"F:ABC-type peptide transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:protein homodimerization activity",
"F:transmembrane transporter activity",
"P:peptide metabolic process",
"P:peptide transport",
"P:protein transport",
"P:transmembrane transport"
] |
[
"ATF2_UP.V1_UP",
"CAHOY_ASTROCYTIC",
"GOBP_AMIDE_TRANSPORT",
"GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION",
"GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN",
"GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I",
"GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_OLIGOPEPTIDE_TRANSPORT",
"GOBP_PEPTIDE_METABOLIC_PROCESS",
"GOBP_PEPTIDE_TRANSPORT",
"GOBP_PROTEIN_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_EARLY_ENDOSOME",
"GOCC_ENDOSOME",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_OLIGOPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_PEROXISOME",
"KEGG_ABC_TRANSPORTERS",
"KEGG_LYSOSOME",
"NOTCH_DN.V1_DN",
"PRC2_EED_DN.V1_DN",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCC1
|
P33527
|
Multidrug resistance-associated protein 1
|
Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[] |
[
"C:apical plasma membrane",
"C:basal plasma membrane",
"C:basolateral plasma membrane",
"C:extracellular exosome",
"C:lateral plasma membrane",
"C:membrane",
"C:plasma membrane",
"F:ABC-type glutathione S-conjugate transporter activity",
"F:ABC-type transporter activity",
"F:ABC-type vitamin B12 transporter activity",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled carboxylic acid transmembrane transporter activity",
"F:ATPase-coupled inorganic anion transmembrane transporter activity",
"F:ATPase-coupled lipid transmembrane transporter activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:bilirubin transmembrane transporter activity",
"F:carboxylic acid transmembrane transporter activity",
"F:efflux transmembrane transporter activity",
"F:glutathione transmembrane transporter activity",
"F:sphingolipid transporter activity",
"F:xenobiotic transmembrane transporter activity",
"P:amygdala development",
"P:amyloid-beta clearance",
"P:amyloid-beta metabolic process",
"P:antigen processing and presentation of lipid antigen via MHC class Ib",
"P:blood vessel diameter maintenance",
"P:carboxylic acid transmembrane transport",
"P:cell chemotaxis",
"P:cell redox homeostasis",
"P:cellular response to amyloid-beta",
"P:cellular response to oxidative stress",
"P:cellular response to type II interferon",
"P:cobalamin transport",
"P:cyclic nucleotide transport",
"P:defense response to Gram-positive bacterium",
"P:endothelial cell apoptotic process",
"P:endothelium development",
"P:establishment of localization in cell",
"P:exploration behavior",
"P:export across plasma membrane",
"P:gene expression",
"P:glucocorticoid metabolic process",
"P:glutathione metabolic process",
"P:glutathione transmembrane transport",
"P:granuloma formation",
"P:heme catabolic process",
"P:hippocampus development",
"P:hydrogen peroxide biosynthetic process",
"P:inflammatory response to antigenic stimulus",
"P:intracellular nitrogen homeostasis",
"P:leukotriene biosynthetic process",
"P:leukotriene metabolic process",
"P:leukotriene transport",
"P:lymphocyte migration",
"P:macrophage activation",
"P:memory",
"P:multicellular organism growth",
"P:neural tissue regeneration",
"P:neurogenesis",
"P:NK T cell activation",
"P:phospholipid translocation",
"P:pigment accumulation",
"P:positive regulation of inflammatory response",
"P:protein localization to cell surface",
"P:regulation of membrane potential",
"P:response to fluid shear stress",
"P:response to glucocorticoid",
"P:response to toxic substance",
"P:response to xenobiotic stimulus",
"P:sphingolipid biosynthetic process",
"P:sphingolipid translocation",
"P:superoxide anion generation",
"P:tissue homeostasis",
"P:transepithelial transport",
"P:transmembrane transport",
"P:transport across blood-brain barrier",
"P:xenobiotic metabolic process",
"P:xenobiotic transport",
"P:xenobiotic transport across blood-brain barrier"
] |
[
"BIOCARTA_MRP_PATHWAY",
"GOBP_AMIDE_TRANSPORT",
"GOBP_CELLULAR_RESPONSE_TO_AMYLOID_BETA",
"GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_CELLULAR_RESPONSE_TO_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_CELL_CHEMOTAXIS",
"GOBP_CELL_MOTILITY",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_COBALAMIN_TRANSPORT",
"GOBP_CYCLIC_NUCLEOTIDE_TRANSPORT",
"GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_EXPORT_FROM_CELL",
"GOBP_GLUTATHIONE_TRANSMEMBRANE_TRANSPORT",
"GOBP_GLUTATHIONE_TRANSPORT",
"GOBP_ICOSANOID_METABOLIC_PROCESS",
"GOBP_ICOSANOID_TRANSPORT",
"GOBP_INFLAMMATORY_RESPONSE",
"GOBP_LEUKOTRIENE_METABOLIC_PROCESS",
"GOBP_LEUKOTRIENE_TRANSPORT",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LOCOMOTION",
"GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_MODIFIED_AMINO_ACID_TRANSPORT",
"GOBP_MONOATOMIC_ANION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT",
"GOBP_NUCLEOTIDE_TRANSPORT",
"GOBP_OLIGOPEPTIDE_TRANSPORT",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PEPTIDE_TRANSPORT",
"GOBP_PHOSPHOLIPID_TRANSLOCATION",
"GOBP_PHOSPHOLIPID_TRANSPORT",
"GOBP_PIGMENT_CATABOLIC_PROCESS",
"GOBP_PIGMENT_METABOLIC_PROCESS",
"GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE",
"GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_REGULATION_OF_INFLAMMATORY_RESPONSE",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION",
"GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_REGULATION_OF_RESPONSE_TO_STRESS",
"GOBP_RESPONSE_TO_AMYLOID_BETA",
"GOBP_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_RESPONSE_TO_OXIDATIVE_STRESS",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_SPHINGOLIPID_METABOLIC_PROCESS",
"GOBP_SPHINGOLIPID_TRANSLOCATION",
"GOBP_SULFUR_COMPOUND_TRANSPORT",
"GOBP_TAXIS",
"GOBP_TETRAPYRROLE_CATABOLIC_PROCESS",
"GOBP_TETRAPYRROLE_METABOLIC_PROCESS",
"GOBP_TRANSEPITHELIAL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORT",
"GOBP_TRIPEPTIDE_TRANSPORT",
"GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM",
"GOBP_VASCULAR_TRANSPORT",
"GOBP_VITAMIN_TRANSPORT",
"GOBP_XENOBIOTIC_METABOLIC_PROCESS",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_BASAL_PART_OF_CELL",
"GOCC_BASOLATERAL_PLASMA_MEMBRANE",
"GOCC_LATERAL_PLASMA_MEMBRANE",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_GLUTATHIONE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_OLIGOPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY",
"HALLMARK_UV_RESPONSE_DN",
"KEGG_ABC_TRANSPORTERS",
"PID_S1P_META_PATHWAY",
"PID_S1P_S1P1_PATHWAY",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ARACHIDONATE_METABOLISM",
"REACTOME_CELLULAR_RESPONSES_TO_STIMULI",
"REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS",
"REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM",
"REACTOME_CYTOPROTECTION_BY_HMOX1",
"REACTOME_DRUG_ADME",
"REACTOME_FATTY_ACID_METABOLISM",
"REACTOME_HEME_DEGRADATION",
"REACTOME_KEAP1_NFE2L2_PATHWAY",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_METABOLISM_OF_PORPHYRINS",
"REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS",
"REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS",
"REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES",
"REACTOME_NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2",
"REACTOME_PARACETAMOL_ADME",
"REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS",
"REACTOME_SPHINGOLIPID_METABOLISM",
"REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX",
"REACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_16P1311_COPY_NUMBER_VARIATION_SYNDROME",
"WP_IRINOTECAN_PATHWAY",
"WP_LEUKOTRIENE_METABOLIC_PATHWAY",
"WP_TROP2_REGULATORY_SIGNALING"
] |
ABCC10
|
Q5T3U5
|
ATP-binding cassette sub-family C member 10
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:12527806, PubMed:15256465). May regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Mediates intercellular propagation of antiviral immune signaling in early stages of infection (By similarity). In RNA virus-infected cells, oligoadenylate synthase senses viral dsRNA and generates 2',5'-oligoadenylates (2-5A) which act as second messengers to activate RNASEL and type I interferon signaling to inhibit viral replication (By similarity). This innate signaling pathway is locally extended and amplified by ABCC10, which exports 2-5A from virus-infected cells to cross-activates RNASEL in uninfected neighboring cells and confers protection against viral infection (By similarity). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed:15256465, PubMed:23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed:12527806)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[] |
[
"C:basal plasma membrane",
"C:basolateral plasma membrane",
"C:lysosomal membrane",
"C:plasma membrane",
"F:ABC-type glutathione S-conjugate transporter activity",
"F:ABC-type transporter activity",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled inorganic anion transmembrane transporter activity",
"P:leukotriene metabolic process",
"P:leukotriene transport",
"P:lipid transport",
"P:organic anion transport",
"P:transmembrane transport"
] |
[
"CSR_EARLY_UP.V1_DN",
"GOBP_ICOSANOID_METABOLIC_PROCESS",
"GOBP_ICOSANOID_TRANSPORT",
"GOBP_LEUKOTRIENE_METABOLIC_PROCESS",
"GOBP_LEUKOTRIENE_TRANSPORT",
"GOBP_LIPID_LOCALIZATION",
"GOBP_MONOATOMIC_ANION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOCC_BASAL_PART_OF_CELL",
"GOCC_BASOLATERAL_PLASMA_MEMBRANE",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCC11
|
Q96J66
|
ATP-binding cassette sub-family C member 11
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Plays a role in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides, including cAMP and cGMP (PubMed:12764137, PubMed:15537867). Mediates the ATP-dependent efflux of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates, such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:16359813, PubMed:25896536). Plays a role in the transport of earwax components (PubMed:16444273, PubMed:19383836). Participates in the secretion of odorants and their precursors from the apocrine sweat glands, including the secretion of glutamine conjugates, as well as the Cys-Gly-(S) conjugates of 3-methyl-3-sulfanyl-hexanol (PubMed:19710689). Involved in the cellular extrusion of nucleotide analogs, hence confering resistance to various drugs, including clinically relevant drugs such as 5-fluorouracil (5-FU) and methotrexate (PubMed:12764137, PubMed:15537867, PubMed:25896536)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[] |
[
"C:apical plasma membrane",
"C:cytoplasmic vesicle membrane",
"C:extracellular exosome",
"C:plasma membrane",
"C:vacuolar membrane",
"F:ABC-type bile acid transporter activity",
"F:ABC-type glutathione S-conjugate transporter activity",
"F:ABC-type transporter activity",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled inorganic anion transmembrane transporter activity",
"F:organic anion transmembrane transporter activity",
"F:purine nucleotide transmembrane transporter activity",
"P:bile acid and bile salt transport",
"P:leukotriene transport",
"P:organic anion transport",
"P:purine nucleotide transport",
"P:transmembrane transport",
"P:xenobiotic transport"
] |
[
"GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT",
"GOBP_ICOSANOID_TRANSPORT",
"GOBP_LEUKOTRIENE_TRANSPORT",
"GOBP_LIPID_LOCALIZATION",
"GOBP_MONOATOMIC_ANION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT",
"GOBP_NUCLEOTIDE_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PURINE_NUCLEOTIDE_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PURINE_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCC12
|
Q96J65
|
ATP-binding cassette sub-family C member 12
|
Probable transporter, its substrate specificity is unknown
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[] |
[
"C:endoplasmic reticulum",
"C:endoplasmic reticulum membrane",
"C:membrane",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"P:transmembrane transport"
] |
[
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS"
] |
ABCC2
|
Q92887
|
ATP-binding cassette sub-family C member 2
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[
"NFKB1"
] |
[
"C:apical plasma membrane",
"C:cell surface",
"C:intercellular canaliculus",
"C:plasma membrane",
"C:vesicle",
"F:ABC-type glutathione S-conjugate transporter activity",
"F:ABC-type transporter activity",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled inorganic anion transmembrane transporter activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:bilirubin transmembrane transporter activity",
"F:organic anion transmembrane transporter activity",
"F:toxin transmembrane transporter activity",
"F:xenobiotic transmembrane transporter activity",
"P:bile acid and bile salt transport",
"P:bilirubin transport",
"P:cardiac muscle cell differentiation",
"P:gene expression",
"P:glucuronoside transport",
"P:glutathione metabolic process",
"P:glutathione transport",
"P:heme catabolic process",
"P:leukotriene transport",
"P:mercury ion transport",
"P:mRNA metabolic process",
"P:negative regulation of gene expression",
"P:phosphatidylinositol 3-kinase/protein kinase B signal transduction",
"P:proximal tubule development",
"P:response to cisplatin",
"P:response to growth hormone",
"P:response to insulin",
"P:response to peptide",
"P:response to wortmannin",
"P:transepithelial transport",
"P:transmembrane transport",
"P:transport across blood-brain barrier",
"P:xenobiotic detoxification by transmembrane export across the plasma membrane",
"P:xenobiotic export from cell",
"P:xenobiotic metabolic process",
"P:xenobiotic transmembrane transport",
"P:xenobiotic transport across blood-brain barrier"
] |
[
"BIOCARTA_NUCLEARRS_PATHWAY",
"GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT",
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_DICARBOXYLIC_ACID_TRANSPORT",
"GOBP_EXPORT_FROM_CELL",
"GOBP_ICOSANOID_TRANSPORT",
"GOBP_LEUKOTRIENE_TRANSPORT",
"GOBP_LIPID_LOCALIZATION",
"GOBP_MONOATOMIC_ANION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_PIGMENT_CATABOLIC_PROCESS",
"GOBP_PIGMENT_METABOLIC_PROCESS",
"GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_TETRAPYRROLE_CATABOLIC_PROCESS",
"GOBP_TETRAPYRROLE_METABOLIC_PROCESS",
"GOBP_TRANSEPITHELIAL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM",
"GOBP_VASCULAR_TRANSPORT",
"GOBP_XENOBIOTIC_EXPORT_FROM_CELL",
"GOBP_XENOBIOTIC_METABOLIC_PROCESS",
"GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER",
"GOCC_ANCHORING_JUNCTION",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_CELL_CELL_JUNCTION",
"GOCC_CELL_SURFACE",
"GOCC_INTERCELLULAR_CANALICULUS",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_XENOBIOTIC_METABOLISM",
"KEGG_ABC_TRANSPORTERS",
"NFE2L2.V2",
"P53_DN.V1_DN",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_ASPIRIN_ADME",
"REACTOME_ATORVASTATIN_ADME",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_DRUG_ADME",
"REACTOME_HEME_DEGRADATION",
"REACTOME_METABOLISM_OF_PORPHYRINS",
"REACTOME_PARACETAMOL_ADME",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_CHOLESTASIS",
"WP_CODEINE_AND_MORPHINE_METABOLISM",
"WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY",
"WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT",
"WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY",
"WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS",
"WP_FOXA2_PATHWAY",
"WP_IRINOTECAN_PATHWAY",
"WP_NRF2_PATHWAY",
"WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY",
"WP_NUCLEAR_RECEPTORS_METAPATHWAY",
"WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING",
"WP_PREGNANE_X_RECEPTOR_PATHWAY",
"WP_PROXIMAL_TUBULE_TRANSPORT"
] |
ABCC3
|
O15438
|
ATP-binding cassette sub-family C member 3
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, PubMed:11581266, PubMed:15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:11581266, PubMed:15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:10359813, PubMed:11581266)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[] |
[
"C:basal plasma membrane",
"C:basolateral plasma membrane",
"C:ciliary basal body",
"C:plasma membrane",
"F:ABC-type bile acid transporter activity",
"F:ABC-type glutathione S-conjugate transporter activity",
"F:ABC-type transporter activity",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled inorganic anion transmembrane transporter activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:glucuronoside transmembrane transporter activity",
"F:icosanoid transmembrane transporter activity",
"F:xenobiotic transmembrane transporter activity",
"P:bile acid and bile salt transport",
"P:leukotriene transport",
"P:transmembrane transport",
"P:transport across blood-brain barrier",
"P:xenobiotic metabolic process",
"P:xenobiotic transmembrane transport",
"P:xenobiotic transport"
] |
[
"ATF2_S_UP.V1_DN",
"ATF2_UP.V1_DN",
"BIOCARTA_MRP_PATHWAY",
"BIOCARTA_NUCLEARRS_PATHWAY",
"EGFR_UP.V1_UP",
"ERBB2_UP.V1_UP",
"GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT",
"GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT",
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_GLYCOSIDE_TRANSPORT",
"GOBP_ICOSANOID_TRANSPORT",
"GOBP_LEUKOTRIENE_TRANSPORT",
"GOBP_LIPID_LOCALIZATION",
"GOBP_MONOATOMIC_ANION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM",
"GOBP_VASCULAR_TRANSPORT",
"GOBP_XENOBIOTIC_METABOLIC_PROCESS",
"GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOCC_BASAL_PART_OF_CELL",
"GOCC_BASOLATERAL_PLASMA_MEMBRANE",
"GOCC_CILIARY_BASAL_BODY",
"GOCC_CILIUM",
"GOCC_MICROTUBULE_CYTOSKELETON",
"GOCC_MICROTUBULE_ORGANIZING_CENTER",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_CARBOHYDRATE_DERIVATIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_ICOSANOID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_XENOBIOTIC_METABOLISM",
"KEGG_ABC_TRANSPORTERS",
"LTE2_UP.V1_UP",
"MEK_UP.V1_UP",
"RAF_UP.V1_UP",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ASPIRIN_ADME",
"REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM",
"REACTOME_CELLULAR_RESPONSES_TO_STIMULI",
"REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS",
"REACTOME_DRUG_ADME",
"REACTOME_KEAP1_NFE2L2_PATHWAY",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_METABOLISM_OF_STEROIDS",
"REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES",
"REACTOME_NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2",
"REACTOME_PARACETAMOL_ADME",
"REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WNT_UP.V1_DN",
"WP_CHOLESTASIS",
"WP_CODEINE_AND_MORPHINE_METABOLISM",
"WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY",
"WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT",
"WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY",
"WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS",
"WP_FLUOROPYRIMIDINE_ACTIVITY",
"WP_FOXA2_PATHWAY",
"WP_NRF2_PATHWAY",
"WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY",
"WP_NUCLEAR_RECEPTORS_METAPATHWAY",
"WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING",
"WP_PREGNANE_X_RECEPTOR_PATHWAY"
] |
ABCC4
|
O15439
|
ATP-binding cassette sub-family C member 4
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (PubMed:11856762, PubMed:12523936, PubMed:15364914, PubMed:38886124, PubMed:40138312). Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430, PubMed:38886124, PubMed:40138312). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[
"DLG1",
"DLG2",
"DLG4",
"MAGI1",
"MAGI2",
"MAGI3",
"MPDZ",
"MPP1",
"NHERF2",
"PATJ",
"PDZD2",
"PDZD7",
"PDZK1",
"SCRIB"
] |
[
"C:apical plasma membrane",
"C:basolateral plasma membrane",
"C:external side of apical plasma membrane",
"C:Golgi apparatus",
"C:membrane",
"C:nucleolus",
"C:plasma membrane",
"C:platelet dense granule membrane",
"F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity",
"F:ABC-type bile acid transporter activity",
"F:ABC-type glutathione S-conjugate transporter activity",
"F:ABC-type transporter activity",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled inorganic anion transmembrane transporter activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:efflux transmembrane transporter activity",
"F:glutathione transmembrane transporter activity",
"F:guanine nucleotide transmembrane transporter activity",
"F:prostaglandin transmembrane transporter activity",
"F:purine nucleotide transmembrane transporter activity",
"F:urate transmembrane transporter activity",
"F:xenobiotic transmembrane transporter activity",
"P:bile acid and bile salt transport",
"P:cAMP transport",
"P:cilium assembly",
"P:export across plasma membrane",
"P:kynurenic acid metabolic process",
"P:L-tryptophan metabolic process",
"P:leukotriene transport",
"P:platelet degranulation",
"P:prostaglandin secretion",
"P:prostaglandin transport",
"P:transmembrane transport",
"P:transport across blood-brain barrier",
"P:urate transport",
"P:xenobiotic metabolic process",
"P:xenobiotic transmembrane transport"
] |
[
"GOBP_AMIDE_TRANSPORT",
"GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT",
"GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT",
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_CELL_CELL_SIGNALING",
"GOBP_CELL_PROJECTION_ASSEMBLY",
"GOBP_CELL_PROJECTION_ORGANIZATION",
"GOBP_CILIUM_ORGANIZATION",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_CYCLIC_NUCLEOTIDE_TRANSPORT",
"GOBP_EXOCYTOSIS",
"GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_EXPORT_FROM_CELL",
"GOBP_FATTY_ACID_TRANSPORT",
"GOBP_GLUTATHIONE_TRANSMEMBRANE_TRANSPORT",
"GOBP_GLUTATHIONE_TRANSPORT",
"GOBP_GUANINE_NUCLEOTIDE_TRANSPORT",
"GOBP_ICOSANOID_SECRETION",
"GOBP_ICOSANOID_TRANSPORT",
"GOBP_LEUKOTRIENE_TRANSPORT",
"GOBP_LIPID_EXPORT_FROM_CELL",
"GOBP_LIPID_LOCALIZATION",
"GOBP_MODIFIED_AMINO_ACID_TRANSPORT",
"GOBP_MONOATOMIC_ANION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT",
"GOBP_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT",
"GOBP_NUCLEOTIDE_TRANSPORT",
"GOBP_OLIGOPEPTIDE_TRANSPORT",
"GOBP_ORGANELLE_ASSEMBLY",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PEPTIDE_TRANSPORT",
"GOBP_PLATELET_DEGRANULATION",
"GOBP_PROSTAGLANDIN_SECRETION",
"GOBP_PROSTAGLANDIN_TRANSPORT",
"GOBP_PURINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT",
"GOBP_PURINE_NUCLEOTIDE_TRANSPORT",
"GOBP_REGULATED_EXOCYTOSIS",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_SECRETION",
"GOBP_SIGNAL_RELEASE",
"GOBP_SULFUR_COMPOUND_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORT",
"GOBP_TRIPEPTIDE_TRANSPORT",
"GOBP_URATE_TRANSPORT",
"GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM",
"GOBP_VASCULAR_TRANSPORT",
"GOBP_VESICLE_MEDIATED_TRANSPORT",
"GOBP_XENOBIOTIC_METABOLIC_PROCESS",
"GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_BASAL_PART_OF_CELL",
"GOCC_BASOLATERAL_PLASMA_MEMBRANE",
"GOCC_CELL_SURFACE",
"GOCC_EXTERNAL_SIDE_OF_APICAL_PLASMA_MEMBRANE",
"GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE",
"GOCC_GOLGI_APPARATUS",
"GOCC_NUCLEOLUS",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_PLATELET_DENSE_GRANULE",
"GOCC_PLATELET_DENSE_GRANULE_MEMBRANE",
"GOCC_SECRETORY_GRANULE",
"GOCC_SECRETORY_GRANULE_MEMBRANE",
"GOCC_SECRETORY_VESICLE",
"GOCC_SIDE_OF_MEMBRANE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_GLUTATHIONE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_GUANINE_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_ICOSANOID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_OLIGOPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_OXIDOREDUCTASE_ACTIVITY",
"GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PURINE_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SALT_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_ANDROGEN_RESPONSE",
"KEGG_ABC_TRANSPORTERS",
"MEK_UP.V1_UP",
"MYC_UP.V1_UP",
"RAF_UP.V1_UP",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_AZATHIOPRINE_ADME",
"REACTOME_DRUG_ADME",
"REACTOME_HEMOSTASIS",
"REACTOME_PARACETAMOL_ADME",
"REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION",
"REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER",
"WP_ASPIRIN_AND_MIRNAS",
"WP_CHOLESTASIS",
"WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT",
"WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY",
"WP_ECTODERM_DIFFERENTIATION",
"WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS",
"WP_FLUOROPYRIMIDINE_ACTIVITY",
"WP_FOXA2_PATHWAY",
"WP_NRF2_PATHWAY",
"WP_NUCLEAR_RECEPTORS_METAPATHWAY",
"WP_OMEGA6FATTY_ACIDS_IN_SENESCENCE",
"WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING",
"WP_PREGNANE_X_RECEPTOR_PATHWAY",
"WP_PROSTAGLANDIN_SYNTHESIS_AND_REGULATION",
"WP_PROXIMAL_TUBULE_TRANSPORT",
"WP_TYROBP_CAUSAL_NETWORK_IN_MICROGLIA"
] |
ABCC5
|
O15440
|
ATP-binding cassette sub-family C member 5
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:12637526, PubMed:12695538, PubMed:15899835, PubMed:17229149, PubMed:25964343). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (PubMed:12695538). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:12435799, PubMed:12695538, PubMed:15899835). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[] |
[
"C:apical plasma membrane",
"C:basolateral plasma membrane",
"C:endosome membrane",
"C:Golgi lumen",
"C:membrane",
"C:plasma membrane",
"F:ABC-type transporter activity",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled inorganic anion transmembrane transporter activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:carbohydrate derivative transmembrane transporter activity",
"F:efflux transmembrane transporter activity",
"F:glutathione transmembrane transporter activity",
"F:heme transmembrane transporter activity",
"F:macromolecule transmembrane transporter activity",
"F:organic anion transmembrane transporter activity",
"F:purine nucleotide transmembrane transporter activity",
"F:xenobiotic transmembrane transporter activity",
"P:cAMP transport",
"P:carbohydrate derivative transport",
"P:cGMP transport",
"P:export across plasma membrane",
"P:folate transmembrane transport",
"P:glutathione transmembrane transport",
"P:heme transmembrane transport",
"P:hyaluronan biosynthetic process",
"P:purine nucleotide transport",
"P:transmembrane transport",
"P:transport across blood-brain barrier",
"P:xenobiotic detoxification by transmembrane export across the plasma membrane",
"P:xenobiotic metabolic process",
"P:xenobiotic transmembrane transport",
"P:xenobiotic transport"
] |
[
"GOBP_AMIDE_TRANSPORT",
"GOBP_AMINOGLYCAN_BIOSYNTHETIC_PROCESS",
"GOBP_AMINOGLYCAN_METABOLIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT",
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_CYCLIC_NUCLEOTIDE_TRANSPORT",
"GOBP_DETOXIFICATION",
"GOBP_DICARBOXYLIC_ACID_TRANSPORT",
"GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_EXPORT_FROM_CELL",
"GOBP_FOLIC_ACID_TRANSPORT",
"GOBP_GLUTATHIONE_TRANSMEMBRANE_TRANSPORT",
"GOBP_GLUTATHIONE_TRANSPORT",
"GOBP_GLYCOSAMINOGLYCAN_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCOSAMINOGLYCAN_METABOLIC_PROCESS",
"GOBP_GUANINE_NUCLEOTIDE_TRANSPORT",
"GOBP_HEME_TRANSPORT",
"GOBP_HYALURONAN_BIOSYNTHETIC_PROCESS",
"GOBP_HYALURONAN_METABOLIC_PROCESS",
"GOBP_IRON_COORDINATION_ENTITY_TRANSPORT",
"GOBP_IRON_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_IRON_ION_TRANSPORT",
"GOBP_METAL_ION_TRANSPORT",
"GOBP_MODIFIED_AMINO_ACID_TRANSPORT",
"GOBP_MONOATOMIC_ANION_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT",
"GOBP_NUCLEOTIDE_TRANSPORT",
"GOBP_OLIGOPEPTIDE_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PEPTIDE_TRANSPORT",
"GOBP_PURINE_NUCLEOTIDE_TRANSPORT",
"GOBP_RESPONSE_TO_TOXIC_SUBSTANCE",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_SULFUR_COMPOUND_TRANSPORT",
"GOBP_TRANSITION_METAL_ION_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORT",
"GOBP_TRIPEPTIDE_TRANSPORT",
"GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM",
"GOBP_VASCULAR_TRANSPORT",
"GOBP_VITAMIN_TRANSMEMBRANE_TRANSPORT",
"GOBP_VITAMIN_TRANSPORT",
"GOBP_XENOBIOTIC_EXPORT_FROM_CELL",
"GOBP_XENOBIOTIC_METABOLIC_PROCESS",
"GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_BASAL_PART_OF_CELL",
"GOCC_BASOLATERAL_PLASMA_MEMBRANE",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_GOLGI_APPARATUS",
"GOCC_GOLGI_LUMEN",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_CARBOHYDRATE_DERIVATIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_GLUTATHIONE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HEME_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_OLIGOPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PURINE_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_P53_PATHWAY",
"HALLMARK_PEROXISOME",
"KEGG_ABC_TRANSPORTERS",
"MEL18_DN.V1_UP",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_AZATHIOPRINE_ADME",
"REACTOME_DRUG_ADME",
"REACTOME_GLYCOSAMINOGLYCAN_METABOLISM",
"REACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT",
"REACTOME_HYALURONAN_METABOLISM",
"REACTOME_METABOLISM_OF_CARBOHYDRATES_AND_CARBOHYDRATE_DERIVATIVES",
"REACTOME_PARACETAMOL_ADME",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_FLUOROPYRIMIDINE_ACTIVITY",
"WP_NRF2_PATHWAY",
"WP_NUCLEAR_RECEPTORS_METAPATHWAY"
] |
ABCC6
|
O95255
|
ATP-binding cassette sub-family C member 6
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[] |
[
"C:basal plasma membrane",
"C:basolateral plasma membrane",
"C:endoplasmic reticulum membrane",
"C:extracellular region",
"C:nucleoplasm",
"C:plasma membrane",
"F:ABC-type glutathione S-conjugate transporter activity",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled inorganic anion transmembrane transporter activity",
"F:ATPase-coupled transmembrane transporter activity",
"P:ATP metabolic process",
"P:ATP transport",
"P:calcium ion homeostasis",
"P:gene expression",
"P:inhibition of non-skeletal tissue mineralization",
"P:inorganic diphosphate transport",
"P:intracellular phosphate ion homeostasis",
"P:leukotriene transport",
"P:phosphate ion homeostasis",
"P:response to magnesium ion",
"P:response to sodium phosphate",
"P:response to xenobiotic stimulus",
"P:transmembrane transport",
"P:visual perception"
] |
[
"ESC_V6.5_UP_EARLY.V1_UP",
"GOBP_ATP_METABOLIC_PROCESS",
"GOBP_ATP_TRANSPORT",
"GOBP_CALCIUM_ION_HOMEOSTASIS",
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT",
"GOBP_CELLULAR_HOMEOSTASIS",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_ICOSANOID_TRANSPORT",
"GOBP_INORGANIC_ANION_TRANSPORT",
"GOBP_INORGANIC_ION_HOMEOSTASIS",
"GOBP_INTRACELLULAR_PHOSPHATE_ION_HOMEOSTASIS",
"GOBP_LEUKOTRIENE_TRANSPORT",
"GOBP_MONOATOMIC_ANION_TRANSPORT",
"GOBP_MONOATOMIC_ION_HOMEOSTASIS",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS",
"GOBP_NERVOUS_SYSTEM_PROCESS",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT",
"GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS",
"GOBP_NUCLEOTIDE_METABOLIC_PROCESS",
"GOBP_NUCLEOTIDE_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHATE_ION_HOMEOSTASIS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_PURINE_NUCLEOTIDE_TRANSPORT",
"GOBP_RESPONSE_TO_MAGNESIUM_ION",
"GOBP_RESPONSE_TO_METAL_ION",
"GOBP_RESPONSE_TO_SALT",
"GOBP_RESPONSE_TO_SODIUM_PHOSPHATE",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_RIBOSE_PHOSPHATE_METABOLIC_PROCESS",
"GOBP_SENSORY_PERCEPTION",
"GOBP_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_TISSUE_HOMEOSTASIS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_BASAL_PART_OF_CELL",
"GOCC_BASOLATERAL_PLASMA_MEMBRANE",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"KRAS.AMP.LUNG_UP.V1_UP",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_16P1311_COPY_NUMBER_VARIATION_SYNDROME",
"WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING"
] |
ABCC6P2
| null | null | null |
[] |
[] |
[] |
[
"MYC_UP.V1_UP",
"PDGF_ERK_DN.V1_UP"
] |
ABCC8
|
Q09428
|
ATP-binding cassette sub-family C member 8
|
Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11; KCNJ11 forms the channel pore while ABCC8 is required for activation and regulation
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[
"KCNJ11"
] |
[
"C:inward rectifying potassium channel",
"C:plasma membrane",
"C:potassium ion-transporting ATPase complex",
"C:presynaptic membrane",
"C:sarcolemma",
"C:synaptic vesicle membrane",
"F:ABC-type transporter activity",
"F:ADP binding",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATP-activated inward rectifier potassium channel activity",
"F:ATPase-coupled monoatomic cation transmembrane transporter activity",
"F:metal ion binding",
"F:potassium channel activity",
"F:sulfonylurea receptor activity",
"F:transmembrane transporter binding",
"P:action potential",
"P:cellular response to nutrient levels",
"P:female pregnancy",
"P:glutamate secretion, neurotransmission",
"P:inorganic cation transmembrane transport",
"P:intracellular glucose homeostasis",
"P:memory",
"P:negative regulation of angiogenesis",
"P:negative regulation of blood-brain barrier permeability",
"P:negative regulation of glial cell proliferation",
"P:negative regulation of insulin secretion",
"P:negative regulation of low-density lipoprotein particle clearance",
"P:negative regulation of neuroblast migration",
"P:neuromuscular process",
"P:positive regulation of insulin secretion involved in cellular response to glucose stimulus",
"P:positive regulation of potassium ion transport",
"P:positive regulation of tight junction disassembly",
"P:positive regulation of tumor necrosis factor production",
"P:positive regulation of uterine smooth muscle relaxation",
"P:potassium ion import across plasma membrane",
"P:potassium ion transmembrane transport",
"P:potassium ion transport",
"P:regulation of insulin secretion",
"P:response to insulin",
"P:response to lipopolysaccharide",
"P:response to pH",
"P:response to xenobiotic stimulus",
"P:response to zinc ion",
"P:transmembrane transport",
"P:visual learning"
] |
[
"GOBP_ACIDIC_AMINO_ACID_TRANSPORT",
"GOBP_ACTION_POTENTIAL",
"GOBP_AMIDE_TRANSPORT",
"GOBP_AMINO_ACID_TRANSPORT",
"GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS",
"GOBP_ASSOCIATIVE_LEARNING",
"GOBP_BEHAVIOR",
"GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS",
"GOBP_BLOOD_VESSEL_MORPHOGENESIS",
"GOBP_CARBOHYDRATE_HOMEOSTASIS",
"GOBP_CELLULAR_COMPONENT_DISASSEMBLY",
"GOBP_CELLULAR_HOMEOSTASIS",
"GOBP_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_NUTRIENT_LEVELS",
"GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_CELL_CELL_JUNCTION_DISASSEMBLY",
"GOBP_CELL_CELL_JUNCTION_ORGANIZATION",
"GOBP_CELL_CELL_SIGNALING",
"GOBP_CELL_JUNCTION_DISASSEMBLY",
"GOBP_CELL_JUNCTION_ORGANIZATION",
"GOBP_CELL_MOTILITY",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_COGNITION",
"GOBP_CYTOKINE_PRODUCTION",
"GOBP_DICARBOXYLIC_ACID_TRANSPORT",
"GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_EXPORT_FROM_CELL",
"GOBP_GLIAL_CELL_PROLIFERATION",
"GOBP_GLIOGENESIS",
"GOBP_GLUTAMATE_SECRETION",
"GOBP_GLUTAMATE_SECRETION_NEUROTRANSMISSION",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_HORMONE_TRANSPORT",
"GOBP_IMPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_IMPORT_INTO_CELL",
"GOBP_INORGANIC_ION_IMPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_INSULIN_SECRETION",
"GOBP_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS",
"GOBP_INTRACELLULAR_GLUCOSE_HOMEOSTASIS",
"GOBP_LEARNING",
"GOBP_LOCOMOTION",
"GOBP_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE",
"GOBP_L_AMINO_ACID_TRANSPORT",
"GOBP_L_GLUTAMATE_IMPORT",
"GOBP_MAINTENANCE_OF_BLOOD_BRAIN_BARRIER",
"GOBP_MEMORY",
"GOBP_METAL_ION_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS",
"GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS",
"GOBP_MUSCLE_SYSTEM_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT",
"GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION",
"GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION",
"GOBP_NEGATIVE_REGULATION_OF_GLIOGENESIS",
"GOBP_NEGATIVE_REGULATION_OF_HORMONE_SECRETION",
"GOBP_NEGATIVE_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE",
"GOBP_NEGATIVE_REGULATION_OF_LOCOMOTION",
"GOBP_NEGATIVE_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE",
"GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT",
"GOBP_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION",
"GOBP_NEGATIVE_REGULATION_OF_SECRETION",
"GOBP_NEGATIVE_REGULATION_OF_SIGNALING",
"GOBP_NEGATIVE_REGULATION_OF_TRANSPORT",
"GOBP_NEGATIVE_REGULATION_OF_VASCULAR_PERMEABILITY",
"GOBP_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT",
"GOBP_NERVOUS_SYSTEM_PROCESS",
"GOBP_NEUROBLAST_MIGRATION",
"GOBP_NEUROGENESIS",
"GOBP_NEUROMUSCULAR_PROCESS",
"GOBP_NEUROTRANSMITTER_SECRETION",
"GOBP_NEUROTRANSMITTER_TRANSPORT",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_PEPTIDE_TRANSPORT",
"GOBP_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE",
"GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION",
"GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_GENE_EXPRESSION",
"GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS",
"GOBP_POSITIVE_REGULATION_OF_MONOATOMIC_ION_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_SIGNALING",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION",
"GOBP_POTASSIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_POTASSIUM_ION_TRANSPORT",
"GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION",
"GOBP_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS",
"GOBP_REGULATION_OF_BLOOD_BRAIN_BARRIER_PERMEABILITY",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_CELL_DEVELOPMENT",
"GOBP_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_CELL_POPULATION_PROLIFERATION",
"GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_REGULATION_OF_GLIAL_CELL_PROLIFERATION",
"GOBP_REGULATION_OF_GLIOGENESIS",
"GOBP_REGULATION_OF_HORMONE_LEVELS",
"GOBP_REGULATION_OF_HORMONE_SECRETION",
"GOBP_REGULATION_OF_INSULIN_SECRETION",
"GOBP_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE",
"GOBP_REGULATION_OF_LOCOMOTION",
"GOBP_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE",
"GOBP_REGULATION_OF_MEMBRANE_POTENTIAL",
"GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSPORT",
"GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT",
"GOBP_REGULATION_OF_MUSCLE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT",
"GOBP_REGULATION_OF_NEUROGENESIS",
"GOBP_REGULATION_OF_PEPTIDE_TRANSPORT",
"GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS",
"GOBP_REGULATION_OF_POTASSIUM_ION_TRANSPORT",
"GOBP_REGULATION_OF_PROTEIN_SECRETION",
"GOBP_REGULATION_OF_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_RELAXATION_OF_MUSCLE",
"GOBP_REGULATION_OF_SECRETION",
"GOBP_REGULATION_OF_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_TIGHT_JUNCTION_DISASSEMBLY",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_REGULATION_OF_VASCULAR_PERMEABILITY",
"GOBP_REGULATION_OF_VASCULATURE_DEVELOPMENT",
"GOBP_RELAXATION_OF_MUSCLE",
"GOBP_RELAXATION_OF_SMOOTH_MUSCLE",
"GOBP_REPRODUCTIVE_PROCESS",
"GOBP_RESPONSE_TO_ABIOTIC_STIMULUS",
"GOBP_RESPONSE_TO_BACTERIUM",
"GOBP_RESPONSE_TO_CARBOHYDRATE",
"GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS",
"GOBP_RESPONSE_TO_HORMONE",
"GOBP_RESPONSE_TO_INSULIN",
"GOBP_RESPONSE_TO_LIGHT_STIMULUS",
"GOBP_RESPONSE_TO_LIPID",
"GOBP_RESPONSE_TO_METAL_ION",
"GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN",
"GOBP_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_RESPONSE_TO_NUTRIENT_LEVELS",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_PEPTIDE_HORMONE",
"GOBP_RESPONSE_TO_PH",
"GOBP_RESPONSE_TO_RADIATION",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_RESPONSE_TO_ZINC_ION",
"GOBP_SECRETION",
"GOBP_SIGNAL_RELEASE",
"GOBP_SYNAPTIC_SIGNALING",
"GOBP_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC",
"GOBP_TIGHT_JUNCTION_ORGANIZATION",
"GOBP_TISSUE_HOMEOSTASIS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_TUBE_DEVELOPMENT",
"GOBP_TUBE_MORPHOGENESIS",
"GOBP_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION",
"GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM",
"GOBP_VASCULATURE_DEVELOPMENT",
"GOBP_VISUAL_BEHAVIOR",
"GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX",
"GOCC_CATION_CHANNEL_COMPLEX",
"GOCC_EXOCYTIC_VESICLE",
"GOCC_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX",
"GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_POTASSIUM_CHANNEL_COMPLEX",
"GOCC_PRESYNAPSE",
"GOCC_PRESYNAPTIC_MEMBRANE",
"GOCC_SARCOLEMMA",
"GOCC_SECRETORY_VESICLE",
"GOCC_SYNAPSE",
"GOCC_SYNAPTIC_MEMBRANE",
"GOCC_SYNAPTIC_VESICLE_MEMBRANE",
"GOCC_TRANSPORTER_COMPLEX",
"GOCC_TRANSPORT_VESICLE",
"GOCC_TRANSPORT_VESICLE_MEMBRANE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ADP_BINDING",
"GOMF_ATPASE_COUPLED_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_ACTIVATED_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_GATED_CHANNEL_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY",
"GOMF_LIGAND_GATED_CHANNEL_ACTIVITY",
"GOMF_LIGAND_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY",
"GOMF_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MONOATOMIC_CATION_CHANNEL_ACTIVITY",
"GOMF_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_POTASSIUM_CHANNEL_ACTIVITY",
"GOMF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY",
"GOMF_TRANSMEMBRANE_TRANSPORTER_BINDING",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_VOLTAGE_GATED_CHANNEL_ACTIVITY",
"GOMF_VOLTAGE_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY",
"GOMF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY",
"HALLMARK_PANCREAS_BETA_CELLS",
"HALLMARK_PEROXISOME",
"IL21_UP.V1_UP",
"KEGG_ABC_TRANSPORTERS",
"KEGG_TYPE_II_DIABETES_MELLITUS",
"PID_HNF3B_PATHWAY",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_INTEGRATION_OF_ENERGY_METABOLISM",
"REACTOME_INWARDLY_RECTIFYING_K_CHANNELS",
"REACTOME_NEURONAL_SYSTEM",
"REACTOME_POTASSIUM_CHANNELS",
"REACTOME_REGULATION_OF_INSULIN_SECRETION"
] |
ABCC9
|
O60706
|
ATP-binding cassette sub-family C member 9
|
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (PubMed:9831708). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8 (By similarity)
|
[
"ABC transmembrane type-1 1",
"ABC transporter 1",
"ABC transmembrane type-1 2",
"ABC transporter 2"
] |
[] |
[
"C:inward rectifying potassium channel",
"C:mitochondrion",
"C:plasma membrane",
"C:potassium ion-transporting ATPase complex",
"C:sarcolemma",
"C:sarcomere",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled inorganic anion transmembrane transporter activity",
"F:ATPase-coupled monoatomic cation transmembrane transporter activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:potassium channel activator activity",
"F:potassium channel activity",
"F:potassium channel regulator activity",
"F:protein-containing complex binding",
"F:sulfonylurea receptor activity",
"F:transmembrane transporter binding",
"P:action potential",
"P:ATP metabolic process",
"P:cardiac conduction",
"P:cardiac muscle cell contraction",
"P:cellular respiration",
"P:cellular response to ATP",
"P:cellular response to calcium ion",
"P:cellular response to chemical stress",
"P:cellular response to potassium ion",
"P:cellular response to xenobiotic stimulus",
"P:coronary vasculature development",
"P:defense response to virus",
"P:fatty acid oxidation",
"P:fibroblast proliferation",
"P:gene expression",
"P:heart morphogenesis",
"P:inorganic cation transmembrane transport",
"P:MAPK cascade",
"P:mitochondrion organization",
"P:monoatomic cation transmembrane transport",
"P:negative regulation of apoptotic process",
"P:negative regulation of blood pressure",
"P:oxygen metabolic process",
"P:potassium ion import across plasma membrane",
"P:potassium ion transmembrane transport",
"P:reactive oxygen species biosynthetic process",
"P:regulation of potassium ion transmembrane transport",
"P:regulation of transcription by RNA polymerase II",
"P:response to activity",
"P:response to ATP",
"P:response to estrogen",
"P:response to hydrogen peroxide",
"P:response to hydrogen sulfide",
"P:response to hypoxia",
"P:response to peptide",
"P:skeletal muscle tissue development",
"P:transmembrane transport",
"P:transport across blood-brain barrier",
"P:vasodilation"
] |
[
"CRX_NRL_DN.V1_DN",
"GOBP_ACTIN_FILAMENT_BASED_MOVEMENT",
"GOBP_ACTIN_FILAMENT_BASED_PROCESS",
"GOBP_ACTIN_MEDIATED_CELL_CONTRACTION",
"GOBP_ACTION_POTENTIAL",
"GOBP_ANIMAL_ORGAN_MORPHOGENESIS",
"GOBP_APOPTOTIC_PROCESS",
"GOBP_ATP_METABOLIC_PROCESS",
"GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS",
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_CARDIAC_CONDUCTION",
"GOBP_CARDIAC_MUSCLE_CELL_CONTRACTION",
"GOBP_CARDIAC_MUSCLE_CONTRACTION",
"GOBP_CELLULAR_RESPIRATION",
"GOBP_CELLULAR_RESPONSE_TO_ATP",
"GOBP_CELLULAR_RESPONSE_TO_CALCIUM_ION",
"GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_METAL_ION",
"GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_CELLULAR_RESPONSE_TO_POTASSIUM_ION",
"GOBP_CELLULAR_RESPONSE_TO_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_CORONARY_VASCULATURE_DEVELOPMENT",
"GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM",
"GOBP_DEFENSE_RESPONSE_TO_VIRUS",
"GOBP_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_FIBROBLAST_PROLIFERATION",
"GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY",
"GOBP_HEART_DEVELOPMENT",
"GOBP_HEART_MORPHOGENESIS",
"GOBP_HEART_PROCESS",
"GOBP_IMPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_IMPORT_INTO_CELL",
"GOBP_INORGANIC_ION_IMPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LIPID_MODIFICATION",
"GOBP_LIPID_OXIDATION",
"GOBP_MAPK_CASCADE",
"GOBP_METAL_ION_TRANSPORT",
"GOBP_MITOCHONDRION_ORGANIZATION",
"GOBP_MONOATOMIC_ANION_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_CATION_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_MONOATOMIC_ION_TRANSPORT",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_MUSCLE_CONTRACTION",
"GOBP_MUSCLE_ORGAN_DEVELOPMENT",
"GOBP_MUSCLE_STRUCTURE_DEVELOPMENT",
"GOBP_MUSCLE_SYSTEM_PROCESS",
"GOBP_MUSCLE_TISSUE_DEVELOPMENT",
"GOBP_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE",
"GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH",
"GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS",
"GOBP_NUCLEOTIDE_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_OXYGEN_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_POTASSIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_POTASSIUM_ION_TRANSPORT",
"GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS",
"GOBP_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE",
"GOBP_REGULATION_OF_BLOOD_CIRCULATION",
"GOBP_REGULATION_OF_BLOOD_PRESSURE",
"GOBP_REGULATION_OF_HEART_CONTRACTION",
"GOBP_REGULATION_OF_MEMBRANE_POTENTIAL",
"GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSPORT",
"GOBP_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT",
"GOBP_REGULATION_OF_POTASSIUM_ION_TRANSPORT",
"GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH",
"GOBP_REGULATION_OF_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_TRANSMEMBRANE_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_REGULATION_OF_TUBE_SIZE",
"GOBP_RESPONSE_TO_ABIOTIC_STIMULUS",
"GOBP_RESPONSE_TO_ACTIVITY",
"GOBP_RESPONSE_TO_ATP",
"GOBP_RESPONSE_TO_CALCIUM_ION",
"GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS",
"GOBP_RESPONSE_TO_ESTROGEN",
"GOBP_RESPONSE_TO_HORMONE",
"GOBP_RESPONSE_TO_HYDROGEN_PEROXIDE",
"GOBP_RESPONSE_TO_METAL_ION",
"GOBP_RESPONSE_TO_NITROGEN_COMPOUND",
"GOBP_RESPONSE_TO_ORGANOPHOSPHORUS",
"GOBP_RESPONSE_TO_OXIDATIVE_STRESS",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_OXYGEN_LEVELS",
"GOBP_RESPONSE_TO_PEPTIDE",
"GOBP_RESPONSE_TO_POTASSIUM_ION",
"GOBP_RESPONSE_TO_PURINE_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES",
"GOBP_RESPONSE_TO_VIRUS",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_RIBOSE_PHOSPHATE_METABOLIC_PROCESS",
"GOBP_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_STRIATED_MUSCLE_CONTRACTION",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM",
"GOBP_VASCULAR_TRANSPORT",
"GOBP_VASCULATURE_DEVELOPMENT",
"GOBP_VASODILATION",
"GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX",
"GOCC_CATION_CHANNEL_COMPLEX",
"GOCC_CONTRACTILE_MUSCLE_FIBER",
"GOCC_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_MITOCHONDRION",
"GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX",
"GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_POTASSIUM_CHANNEL_COMPLEX",
"GOCC_SARCOLEMMA",
"GOCC_SUPRAMOLECULAR_COMPLEX",
"GOCC_SUPRAMOLECULAR_POLYMER",
"GOCC_TRANSPORTER_COMPLEX",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_ACTIVATED_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_CHANNEL_ACTIVATOR_ACTIVITY",
"GOMF_GATED_CHANNEL_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY",
"GOMF_LIGAND_GATED_CHANNEL_ACTIVITY",
"GOMF_LIGAND_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY",
"GOMF_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MOLECULAR_FUNCTION_ACTIVATOR_ACTIVITY",
"GOMF_MONOATOMIC_CATION_CHANNEL_ACTIVITY",
"GOMF_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_POTASSIUM_CHANNEL_ACTIVATOR_ACTIVITY",
"GOMF_POTASSIUM_CHANNEL_ACTIVITY",
"GOMF_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY",
"GOMF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING",
"GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY",
"GOMF_TRANSMEMBRANE_TRANSPORTER_BINDING",
"GOMF_TRANSPORTER_ACTIVATOR_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_REGULATOR_ACTIVITY",
"GOMF_VOLTAGE_GATED_CHANNEL_ACTIVITY",
"GOMF_VOLTAGE_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY",
"GOMF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"NRL_DN.V1_DN",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_CARDIAC_CONDUCTION",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_INWARDLY_RECTIFYING_K_CHANNELS",
"REACTOME_ION_HOMEOSTASIS",
"REACTOME_MUSCLE_CONTRACTION",
"REACTOME_NEURONAL_SYSTEM",
"REACTOME_POTASSIUM_CHANNELS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES"
] |
ABCD1
|
P33897
|
ATP-binding cassette sub-family D member 1
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:11248239, PubMed:15682271, PubMed:16946495, PubMed:18757502, PubMed:21145416, PubMed:23671276, PubMed:29397936, PubMed:33500543). Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (PubMed:29397936, PubMed:33500543). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:21145416, PubMed:23671276). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity)
|
[
"ABC transmembrane type-1",
"ABC transporter"
] |
[
"ABCD1",
"ABCD3",
"PEX19",
"Abcd1"
] |
[
"C:cytoplasm",
"C:cytosol",
"C:endoplasmic reticulum membrane",
"C:lysosomal membrane",
"C:membrane",
"C:mitochondrial membrane",
"C:perinuclear region of cytoplasm",
"C:peroxisomal membrane",
"C:peroxisome",
"F:ABC-type fatty-acyl-CoA transporter activity",
"F:ADP binding",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:enzyme binding",
"F:fatty acyl-CoA hydrolase activity",
"F:identical protein binding",
"F:long-chain fatty acid transmembrane transporter activity",
"F:protein homodimerization activity",
"F:very long-chain fatty acyl-CoA hydrolase activity",
"P:alpha-linolenic acid metabolic process",
"P:fatty acid beta-oxidation",
"P:fatty acid derivative biosynthetic process",
"P:fatty acid elongation",
"P:fatty acid homeostasis",
"P:linoleic acid metabolic process",
"P:long-chain fatty acid biosynthetic process",
"P:long-chain fatty acid catabolic process",
"P:long-chain fatty acid import into peroxisome",
"P:myelin maintenance",
"P:negative regulation of cytokine production involved in inflammatory response",
"P:negative regulation of reactive oxygen species biosynthetic process",
"P:neuron projection maintenance",
"P:peroxisomal membrane transport",
"P:peroxisome organization",
"P:positive regulation of fatty acid beta-oxidation",
"P:positive regulation of unsaturated fatty acid biosynthetic process",
"P:regulation of cellular response to oxidative stress",
"P:regulation of fatty acid beta-oxidation",
"P:regulation of mitochondrial depolarization",
"P:regulation of oxidative phosphorylation",
"P:sterol homeostasis",
"P:unsaturated fatty acid biosynthetic process",
"P:very long-chain fatty acid catabolic process",
"P:very long-chain fatty acid metabolic process",
"P:very long-chain fatty-acyl-CoA catabolic process"
] |
[
"ATM_DN.V1_DN",
"GOBP_ACYL_COA_METABOLIC_PROCESS",
"GOBP_AEROBIC_RESPIRATION",
"GOBP_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS",
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_AMIDE_TRANSPORT",
"GOBP_CELLULAR_RESPIRATION",
"GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS",
"GOBP_CELLULAR_RESPONSE_TO_STRESS",
"GOBP_CELL_PROJECTION_ORGANIZATION",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CYTOKINE_PRODUCTION",
"GOBP_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE",
"GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION",
"GOBP_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS",
"GOBP_ENSHEATHMENT_OF_NEURONS",
"GOBP_FATTY_ACID_BETA_OXIDATION",
"GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS",
"GOBP_FATTY_ACID_DERIVATIVE_CATABOLIC_PROCESS",
"GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_FATTY_ACID_ELONGATION",
"GOBP_FATTY_ACID_HOMEOSTASIS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_FATTY_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_FATTY_ACID_TRANSPORT",
"GOBP_FATTY_ACYL_COA_CATABOLIC_PROCESS",
"GOBP_FATTY_ACYL_COA_METABOLIC_PROCESS",
"GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_INFLAMMATORY_RESPONSE",
"GOBP_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_INTRACELLULAR_TRANSPORT",
"GOBP_KETONE_METABOLIC_PROCESS",
"GOBP_LINOLEIC_ACID_METABOLIC_PROCESS",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LIPID_MODIFICATION",
"GOBP_LIPID_OXIDATION",
"GOBP_LONG_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_LONG_CHAIN_FATTY_ACID_TRANSPORT",
"GOBP_MEMBRANE_DEPOLARIZATION",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_MITOCHONDRIAL_DEPOLARIZATION",
"GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_MYELIN_MAINTENANCE",
"GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION",
"GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE",
"GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION",
"GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS",
"GOBP_NEURON_PROJECTION_MAINTENANCE",
"GOBP_NEURON_PROJECTION_ORGANIZATION",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NUCLEOBASE_CONTAINING_COMPOUND_CATABOLIC_PROCESS",
"GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT",
"GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS",
"GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_OXIDATIVE_PHOSPHORYLATION",
"GOBP_PEROXISOMAL_TRANSPORT",
"GOBP_PEROXISOME_ORGANIZATION",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_PLASMA_MEMBRANE_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_BETA_OXIDATION",
"GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE",
"GOBP_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS",
"GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS",
"GOBP_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_AEROBIC_RESPIRATION",
"GOBP_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_CELLULAR_RESPIRATION",
"GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS",
"GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS",
"GOBP_REGULATION_OF_FATTY_ACID_BETA_OXIDATION",
"GOBP_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_FATTY_ACID_OXIDATION",
"GOBP_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY",
"GOBP_REGULATION_OF_KETONE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_MEMBRANE_DEPOLARIZATION",
"GOBP_REGULATION_OF_MEMBRANE_POTENTIAL",
"GOBP_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION",
"GOBP_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL",
"GOBP_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION",
"GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS",
"GOBP_REGULATION_OF_RESPONSE_TO_STRESS",
"GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_RESPONSE_TO_OXIDATIVE_STRESS",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_STEROL_HOMEOSTASIS",
"GOBP_SULFUR_COMPOUND_CATABOLIC_PROCESS",
"GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS",
"GOBP_SULFUR_COMPOUND_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_VERY_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOCC_MICROBODY",
"GOCC_MICROBODY_MEMBRANE",
"GOCC_MITOCHONDRIAL_ENVELOPE",
"GOCC_MITOCHONDRION",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_ENVELOPE",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ACYL_COA_HYDROLASE_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ADP_BINDING",
"GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_DEACYLASE_ACTIVITY",
"GOMF_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LONG_CHAIN_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_THIOLESTER_HYDROLASE_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"HALLMARK_PEROXISOME",
"JNK_DN.V1_UP",
"KEGG_ABC_TRANSPORTERS",
"KEGG_PEROXISOME",
"KRAS.AMP.LUNG_UP.V1_DN",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM",
"REACTOME_BETA_OXIDATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS",
"REACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_FATTY_ACID_METABOLISM",
"REACTOME_LINOLEIC_ACID_LA_METABOLISM",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_PEROXISOMAL_LIPID_METABOLISM",
"REACTOME_PROTEIN_LOCALIZATION",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES",
"WP_VITAMIN_D_RECEPTOR_PATHWAY"
] |
ABCD2
|
Q9UBJ2
|
ATP-binding cassette sub-family D member 2
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:21145416, PubMed:29397936). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable) (PubMed:29397936). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (PubMed:21145416). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:21145416)
|
[
"ABC transmembrane type-1",
"ABC transporter"
] |
[] |
[
"C:cytosol",
"C:peroxisomal membrane",
"C:peroxisome",
"F:ABC-type transporter activity",
"F:amide transmembrane transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:fatty acyl-CoA hydrolase activity",
"F:long-chain fatty acid transmembrane transporter activity",
"F:nucleobase-containing compound transmembrane transporter activity",
"F:organophosphate ester transmembrane transporter activity",
"F:protein heterodimerization activity",
"F:protein homodimerization activity",
"F:sulfur compound transmembrane transporter activity",
"P:alpha-linolenic acid metabolic process",
"P:fatty acid beta-oxidation",
"P:fatty acid derivative biosynthetic process",
"P:linoleic acid metabolic process",
"P:long-chain fatty acid biosynthetic process",
"P:long-chain fatty acid import into peroxisome",
"P:myelin maintenance",
"P:negative regulation of cytokine production involved in inflammatory response",
"P:negative regulation of reactive oxygen species biosynthetic process",
"P:neuron projection maintenance",
"P:peroxisome organization",
"P:positive regulation of fatty acid beta-oxidation",
"P:positive regulation of unsaturated fatty acid biosynthetic process",
"P:response to bacterium",
"P:unsaturated fatty acid biosynthetic process",
"P:very long-chain fatty acid catabolic process",
"P:very long-chain fatty acid metabolic process"
] |
[
"ATF2_S_UP.V1_UP",
"BIOCARTA_NUCLEARRS_PATHWAY",
"CAHOY_ASTROCYTIC",
"GOBP_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS",
"GOBP_AMIDE_TRANSPORT",
"GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS",
"GOBP_CELL_PROJECTION_ORGANIZATION",
"GOBP_CYTOKINE_PRODUCTION",
"GOBP_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE",
"GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION",
"GOBP_ENSHEATHMENT_OF_NEURONS",
"GOBP_FATTY_ACID_BETA_OXIDATION",
"GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS",
"GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_FATTY_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_FATTY_ACID_TRANSPORT",
"GOBP_INFLAMMATORY_RESPONSE",
"GOBP_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_INTRACELLULAR_TRANSPORT",
"GOBP_KETONE_METABOLIC_PROCESS",
"GOBP_LINOLEIC_ACID_METABOLIC_PROCESS",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LIPID_MODIFICATION",
"GOBP_LIPID_OXIDATION",
"GOBP_LONG_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_LONG_CHAIN_FATTY_ACID_TRANSPORT",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_MYELIN_MAINTENANCE",
"GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION",
"GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE",
"GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION",
"GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS",
"GOBP_NEURON_PROJECTION_MAINTENANCE",
"GOBP_NEURON_PROJECTION_ORGANIZATION",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT",
"GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PEROXISOMAL_TRANSPORT",
"GOBP_PEROXISOME_ORGANIZATION",
"GOBP_PLASMA_MEMBRANE_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_BETA_OXIDATION",
"GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE",
"GOBP_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS",
"GOBP_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_FATTY_ACID_BETA_OXIDATION",
"GOBP_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_FATTY_ACID_OXIDATION",
"GOBP_REGULATION_OF_KETONE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_RESPONSE_TO_BACTERIUM",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_VERY_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOCC_MICROBODY",
"GOCC_MICROBODY_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ACYL_COA_HYDROLASE_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_DEACYLASE_ACTIVITY",
"GOMF_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LONG_CHAIN_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_THIOLESTER_HYDROLASE_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"HALLMARK_PEROXISOME",
"HALLMARK_XENOBIOTIC_METABOLISM",
"IL15_UP.V1_DN",
"IL2_UP.V1_DN",
"KEGG_ABC_TRANSPORTERS",
"KEGG_PEROXISOME",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT",
"REACTOME_PROTEIN_LOCALIZATION",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES",
"WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY"
] |
ABCD3
|
P28288
|
ATP-binding cassette sub-family D member 3
|
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:24333844, PubMed:25168382, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:24333844, PubMed:25944712)
|
[
"ABC transmembrane type-1",
"ABC transporter"
] |
[
"ABCD1",
"PEX19",
"GNAO1",
"PABIR3",
"SUB1"
] |
[
"C:cytosol",
"C:membrane",
"C:mitochondrion",
"C:peroxisomal matrix",
"C:peroxisomal membrane",
"C:peroxisome",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:fatty acyl-CoA hydrolase activity",
"F:long-chain fatty acid transmembrane transporter activity",
"F:protein homodimerization activity",
"P:bile acid and bile salt transport",
"P:bile acid biosynthetic process",
"P:fatty acid beta-oxidation",
"P:fatty acid biosynthetic process",
"P:long-chain fatty acid import into peroxisome",
"P:peroxisome organization",
"P:phytanic acid metabolic process",
"P:response to xenobiotic stimulus",
"P:very long-chain fatty acid catabolic process",
"P:very long-chain fatty acid metabolic process"
] |
[
"BIOCARTA_NUCLEARRS_PATHWAY",
"GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT",
"GOBP_BILE_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_BILE_ACID_METABOLIC_PROCESS",
"GOBP_FATTY_ACID_BETA_OXIDATION",
"GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_FATTY_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_FATTY_ACID_TRANSPORT",
"GOBP_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_INTRACELLULAR_TRANSPORT",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LIPID_MODIFICATION",
"GOBP_LIPID_OXIDATION",
"GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_LONG_CHAIN_FATTY_ACID_TRANSPORT",
"GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_PEROXISOMAL_TRANSPORT",
"GOBP_PEROXISOME_ORGANIZATION",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_STEROID_METABOLIC_PROCESS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VERY_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOCC_MICROBODY",
"GOCC_MICROBODY_LUMEN",
"GOCC_MICROBODY_MEMBRANE",
"GOCC_MITOCHONDRION",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ACYL_COA_HYDROLASE_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_DEACYLASE_ACTIVITY",
"GOMF_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LONG_CHAIN_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY",
"GOMF_THIOLESTER_HYDROLASE_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"HALLMARK_PEROXISOME",
"KEGG_ABC_TRANSPORTERS",
"KEGG_PEROXISOME",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT",
"REACTOME_PROTEIN_LOCALIZATION",
"REACTOME_RHOA_GTPASE_CYCLE",
"REACTOME_RHOC_GTPASE_CYCLE",
"REACTOME_RHO_GTPASE_CYCLE",
"REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES",
"WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT",
"WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES",
"WP_FRAGILE_X_SYNDROME",
"WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY"
] |
ABCD4
|
O14678
|
Lysosomal cobalamin transporter ABCD4
|
Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner (PubMed:22922874, PubMed:28572511, PubMed:31467407, PubMed:33845046). Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane (PubMed:27456980). Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791)
|
[
"ABC transmembrane type-1",
"ABC transporter"
] |
[
"ABCD4",
"FAM234B",
"LMBRD1"
] |
[
"C:ATP-binding cassette (ABC) transporter complex",
"C:endoplasmic reticulum membrane",
"C:lysosomal membrane",
"C:membrane",
"C:peroxisomal membrane",
"C:peroxisome",
"F:ABC-type vitamin B12 transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:identical protein binding",
"F:long-chain fatty acid transmembrane transporter activity",
"P:cellular response to leukemia inhibitory factor",
"P:cobalamin metabolic process",
"P:cobalamin transport",
"P:fatty acid beta-oxidation",
"P:long-chain fatty acid import into peroxisome",
"P:peroxisome organization",
"P:transmembrane transport",
"P:very long-chain fatty acid catabolic process"
] |
[
"GOBP_COBALAMIN_METABOLIC_PROCESS",
"GOBP_COBALAMIN_TRANSPORT",
"GOBP_FATTY_ACID_BETA_OXIDATION",
"GOBP_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_FATTY_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_FATTY_ACID_TRANSPORT",
"GOBP_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_INTRACELLULAR_TRANSPORT",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LIPID_MODIFICATION",
"GOBP_LIPID_OXIDATION",
"GOBP_LONG_CHAIN_FATTY_ACID_TRANSPORT",
"GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_PEROXISOMAL_TRANSPORT",
"GOBP_PEROXISOME_ORGANIZATION",
"GOBP_RESPONSE_TO_LEUKEMIA_INHIBITORY_FACTOR",
"GOBP_RESPONSE_TO_PEPTIDE",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_TETRAPYRROLE_METABOLIC_PROCESS",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_VERY_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_VITAMIN_METABOLIC_PROCESS",
"GOBP_VITAMIN_TRANSPORT",
"GOBP_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS",
"GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX",
"GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX",
"GOCC_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_MICROBODY",
"GOCC_MICROBODY_MEMBRANE",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_TRANSPORTER_COMPLEX",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LONG_CHAIN_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"KEGG_PEROXISOME",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM",
"REACTOME_DEFECTS_IN_COBALAMIN_B12_METABOLISM",
"REACTOME_DEFECTS_IN_VITAMIN_AND_COFACTOR_METABOLISM",
"REACTOME_DISEASES_OF_METABOLISM",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS",
"REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS",
"REACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY",
"REACTOME_UPTAKE_OF_DIETARY_COBALAMINS_INTO_ENTEROCYTES",
"WP_ADHD_AND_AUTISM_ASD_PATHWAYS",
"WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES",
"WP_PATHWAYS_INTO_METHIONINE_AND_FOLATE_CYCLES"
] |
ABCE1
|
P61221
|
ATP-binding cassette sub-family E member 1
|
Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332)
|
[
"4Fe-4S ferredoxin-type 1",
"4Fe-4S ferredoxin-type 2",
"ABC transporter 1",
"ABC transporter 2"
] |
[
"EIF3J",
"gag",
"M",
"P"
] |
[
"C:cytoplasm",
"C:cytosol",
"C:cytosolic ribosome",
"C:membrane",
"C:mitochondrial matrix",
"C:mitochondrion",
"F:4 iron, 4 sulfur cluster binding",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:CTPase activity",
"F:endoribonuclease inhibitor activity",
"F:GTPase activity",
"F:iron ion binding",
"F:ribonucleoside triphosphate phosphatase activity",
"F:ribosomal small subunit binding",
"P:negative regulation of endoribonuclease activity",
"P:regulation of translation",
"P:rescue of stalled ribosome",
"P:ribosome disassembly",
"P:translational initiation",
"P:translational termination"
] |
[
"GCNP_SHH_UP_LATE.V1_UP",
"GOBP_CELLULAR_COMPONENT_DISASSEMBLY",
"GOBP_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY",
"GOBP_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY",
"GOBP_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION",
"GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_ORGANELLE_DISASSEMBLY",
"GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION",
"GOBP_PROTEIN_CONTAINING_COMPLEX_DISASSEMBLY",
"GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION",
"GOBP_REGULATION_OF_CATALYTIC_ACTIVITY",
"GOBP_REGULATION_OF_HYDROLASE_ACTIVITY",
"GOBP_REGULATION_OF_MOLECULAR_FUNCTION",
"GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_RIBONUCLEASE_ACTIVITY",
"GOBP_REGULATION_OF_TRANSLATION",
"GOBP_RESCUE_OF_STALLED_RIBOSOME",
"GOBP_RIBOSOME_DISASSEMBLY",
"GOBP_TRANSLATION",
"GOBP_TRANSLATIONAL_ELONGATION",
"GOBP_TRANSLATIONAL_INITIATION",
"GOBP_TRANSLATIONAL_TERMINATION",
"GOCC_CYTOSOLIC_RIBOSOME",
"GOCC_MITOCHONDRIAL_MATRIX",
"GOCC_MITOCHONDRION",
"GOCC_RIBOSOME",
"GOMF_4_IRON_4_SULFUR_CLUSTER_BINDING",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID",
"GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA",
"GOMF_CTPASE_ACTIVITY",
"GOMF_ENDONUCLEASE_ACTIVITY",
"GOMF_ENZYME_INHIBITOR_ACTIVITY",
"GOMF_ENZYME_REGULATOR_ACTIVITY",
"GOMF_GTPASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_IRON_ION_BINDING",
"GOMF_METAL_CLUSTER_BINDING",
"GOMF_MOLECULAR_FUNCTION_INHIBITOR_ACTIVITY",
"GOMF_NUCLEASE_ACTIVITY",
"GOMF_NUCLEASE_INHIBITOR_ACTIVITY",
"GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING",
"GOMF_RIBONUCLEASE_INHIBITOR_ACTIVITY",
"GOMF_RIBONUCLEOPROTEIN_COMPLEX_BINDING",
"GOMF_RIBOSOMAL_SMALL_SUBUNIT_BINDING",
"GOMF_RIBOSOME_BINDING",
"GOMF_RNA_ENDONUCLEASE_ACTIVITY",
"GOMF_RNA_NUCLEASE_ACTIVITY",
"HALLMARK_ALLOGRAFT_REJECTION",
"HALLMARK_MYC_TARGETS_V1",
"PGF_UP.V1_UP",
"REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES",
"REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM",
"REACTOME_INTERFERON_ALPHA_BETA_SIGNALING",
"REACTOME_INTERFERON_SIGNALING",
"REACTOME_OAS_ANTIVIRAL_RESPONSE",
"SNF5_DN.V1_UP"
] |
ABCF1
|
Q8NE71
|
ATP-binding cassette sub-family F member 1
|
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:cytoplasm",
"C:cytosol",
"C:membrane",
"C:nuclear envelope",
"C:nucleoplasm",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ribosome binding",
"F:RNA binding",
"F:translation activator activity",
"F:translation factor activity, RNA binding",
"P:inflammatory response",
"P:positive regulation of translation",
"P:translation",
"P:translational initiation"
] |
[
"GOBP_INFLAMMATORY_RESPONSE",
"GOBP_POSITIVE_REGULATION_OF_GENE_EXPRESSION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_TRANSLATION",
"GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION",
"GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_TRANSLATION",
"GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS",
"GOBP_RIBOSOME_BIOGENESIS",
"GOBP_TRANSLATION",
"GOBP_TRANSLATIONAL_INITIATION",
"GOCC_NUCLEAR_ENVELOPE",
"GOCC_ORGANELLE_ENVELOPE",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING",
"GOMF_RIBONUCLEOPROTEIN_COMPLEX_BINDING",
"GOMF_RIBOSOME_BINDING",
"GOMF_TRANSLATION_ACTIVATOR_ACTIVITY",
"GOMF_TRANSLATION_FACTOR_ACTIVITY",
"GOMF_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING",
"GOMF_TRANSLATION_REGULATOR_ACTIVITY",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"TBK1.DN.48HRS_DN",
"WP_IL18_SIGNALING"
] |
ABCF2
|
Q9UG63
|
ATP-binding cassette sub-family F member 2
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[] |
[
"C:membrane",
"C:plasma membrane",
"F:ATP binding",
"F:ATP hydrolysis activity"
] |
[
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"HALLMARK_MTORC1_SIGNALING",
"REACTOME_CELLULAR_RESPONSES_TO_STIMULI",
"REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS",
"REACTOME_KEAP1_NFE2L2_PATHWAY",
"REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES",
"REACTOME_NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2",
"WP_MIRTARGETED_GENES_IN_LYMPHOCYTES",
"WP_VEGFAVEGFR2_SIGNALING"
] |
|
ABCF3
|
Q9NUQ8
|
ATP-binding cassette sub-family F member 3
|
Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B
|
[
"ABC transporter 1",
"ABC transporter 2"
] |
[
"FCHSD2",
"TRIM27"
] |
[
"C:membrane",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:cadherin binding",
"P:defense response to virus"
] |
[
"GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS",
"GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM",
"GOBP_DEFENSE_RESPONSE_TO_VIRUS",
"GOBP_RESPONSE_TO_VIRUS",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_CADHERIN_BINDING",
"GOMF_CELL_ADHESION_MOLECULE_BINDING",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES"
] |
ABCG1
|
P45844
|
ATP-binding cassette sub-family G member 1
|
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620)
|
[
"ABC transporter",
"ABC transmembrane type-2"
] |
[
"ABCG4",
"AQP6",
"LAMP2",
"PRPF40A",
"SH3GLB1"
] |
[
"C:endoplasmic reticulum membrane",
"C:endosome",
"C:external side of plasma membrane",
"C:Golgi apparatus",
"C:Golgi membrane",
"C:mitochondrion",
"C:nucleoplasm",
"C:plasma membrane",
"C:recycling endosome",
"F:ABC-type sterol transporter activity",
"F:ADP binding",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:cholesterol binding",
"F:cholesterol transfer activity",
"F:floppase activity",
"F:phosphatidylcholine floppase activity",
"F:phospholipid binding",
"F:protein heterodimerization activity",
"F:protein homodimerization activity",
"F:toxin transmembrane transporter activity",
"P:amyloid precursor protein catabolic process",
"P:cellular response to high density lipoprotein particle stimulus",
"P:cholesterol efflux",
"P:cholesterol homeostasis",
"P:cholesterol metabolic process",
"P:glycoprotein transport",
"P:high-density lipoprotein particle remodeling",
"P:intracellular cholesterol transport",
"P:low-density lipoprotein particle remodeling",
"P:negative regulation of cholesterol storage",
"P:negative regulation of macrophage derived foam cell differentiation",
"P:phospholipid efflux",
"P:phospholipid homeostasis",
"P:positive regulation of amyloid-beta formation",
"P:positive regulation of cholesterol biosynthetic process",
"P:positive regulation of cholesterol efflux",
"P:positive regulation of protein secretion",
"P:regulation of cholesterol metabolic process",
"P:response to lipid",
"P:reverse cholesterol transport",
"P:transmembrane transport",
"P:xenobiotic detoxification by transmembrane export across the plasma membrane"
] |
[
"BIOCARTA_NUCLEARRS_PATHWAY",
"ERBB2_UP.V1_UP",
"ESC_J1_UP_EARLY.V1_UP",
"GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS",
"GOBP_ALCOHOL_METABOLIC_PROCESS",
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_AMYLOID_BETA_FORMATION",
"GOBP_AMYLOID_BETA_METABOLIC_PROCESS",
"GOBP_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS",
"GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS",
"GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT",
"GOBP_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_CHOLESTEROL_STORAGE",
"GOBP_DETOXIFICATION",
"GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_EXPORT_FROM_CELL",
"GOBP_FOAM_CELL_DIFFERENTIATION",
"GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_INTRACELLULAR_LIPID_TRANSPORT",
"GOBP_INTRACELLULAR_STEROL_TRANSPORT",
"GOBP_INTRACELLULAR_TRANSPORT",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING",
"GOBP_MEMBRANE_ORGANIZATION",
"GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_STORAGE",
"GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_LIPID_STORAGE",
"GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_NUTRIENT_STORAGE",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PHOSPHOLIPID_EFFLUX",
"GOBP_PHOSPHOLIPID_HOMEOSTASIS",
"GOBP_PHOSPHOLIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_AMIDE_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_FORMATION",
"GOBP_POSITIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_SECRETION",
"GOBP_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION",
"GOBP_PROTEIN_CONTAINING_COMPLEX_REMODELING",
"GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION",
"GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION",
"GOBP_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_AMIDE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_CELL_DIFFERENTIATION",
"GOBP_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_CHOLESTEROL_STORAGE",
"GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_STORAGE",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION",
"GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS",
"GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_PROTEIN_SECRETION",
"GOBP_REGULATION_OF_PROTEIN_TRANSPORT",
"GOBP_REGULATION_OF_SECRETION",
"GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_RESPONSE_TO_LIPID",
"GOBP_RESPONSE_TO_TOXIC_SUBSTANCE",
"GOBP_REVERSE_CHOLESTEROL_TRANSPORT",
"GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS",
"GOBP_SECRETION",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_STEROID_BIOSYNTHETIC_PROCESS",
"GOBP_STEROID_METABOLIC_PROCESS",
"GOBP_STEROL_BIOSYNTHETIC_PROCESS",
"GOBP_STEROL_HOMEOSTASIS",
"GOBP_STEROL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_XENOBIOTIC_EXPORT_FROM_CELL",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOCC_CELL_SURFACE",
"GOCC_ENDOSOME",
"GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE",
"GOCC_GOLGI_APPARATUS",
"GOCC_GOLGI_MEMBRANE",
"GOCC_MITOCHONDRION",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOCC_RECYCLING_ENDOSOME",
"GOCC_SIDE_OF_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ADP_BINDING",
"GOMF_ALCOHOL_BINDING",
"GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_CHOLESTEROL_BINDING",
"GOMF_CHOLESTEROL_TRANSFER_ACTIVITY",
"GOMF_FLOPPASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_BINDING",
"GOMF_LIPID_TRANSFER_ACTIVITY",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY",
"GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY",
"GOMF_PHOSPHOLIPID_BINDING",
"GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY",
"GOMF_STEROID_BINDING",
"GOMF_STEROL_BINDING",
"GOMF_STEROL_TRANSFER_ACTIVITY",
"GOMF_TOXIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"KEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2",
"MEK_UP.V1_UP",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_HDL_REMODELING",
"REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING",
"REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX",
"REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE",
"REACTOME_PLASMA_LIPOPROTEIN_REMODELING",
"REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"TGFB_UP.V1_UP",
"WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES",
"WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS",
"WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS",
"WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY"
] |
ABCG2
|
Q9UNQ0
|
Broad substrate specificity ATP-binding cassette transporter ABCG2
|
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562, PubMed:36749388). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the vitamins riboflavin and biotin into milk (By similarity). Involved in the excretion of the riboflavin-derived compound lumichrome into the intestinal lumen and in its secretion into milk (PubMed:39337371). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response
|
[
"ABC transporter",
"ABC transmembrane type-2"
] |
[
"ABCG2",
"ENPP1",
"PIM1",
"UBC",
"ABCG2"
] |
[
"C:apical plasma membrane",
"C:brush border membrane",
"C:external side of apical plasma membrane",
"C:membrane raft",
"C:mitochondrial membrane",
"C:nucleoplasm",
"C:plasma membrane",
"F:ABC-type xenobiotic transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:biotin transmembrane transporter activity",
"F:efflux transmembrane transporter activity",
"F:identical protein binding",
"F:organic anion transmembrane transporter activity",
"F:protein homodimerization activity",
"F:riboflavin transmembrane transporter activity",
"F:sphingolipid transporter activity",
"F:urate transmembrane transporter activity",
"F:xenobiotic transmembrane transporter activity",
"P:biotin transport",
"P:cellular detoxification",
"P:export across plasma membrane",
"P:organic anion transport",
"P:renal urate salt excretion",
"P:riboflavin transport",
"P:sphingolipid biosynthetic process",
"P:transepithelial transport",
"P:transmembrane transport",
"P:transport across blood-brain barrier",
"P:urate metabolic process",
"P:xenobiotic transport across blood-brain barrier"
] |
[
"E2F3_UP.V1_UP",
"GOBP_AMIDE_TRANSPORT",
"GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE",
"GOBP_CIRCULATORY_SYSTEM_PROCESS",
"GOBP_DETOXIFICATION",
"GOBP_EXCRETION",
"GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE",
"GOBP_EXPORT_FROM_CELL",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_TRANSPORT",
"GOBP_NITROGEN_COMPOUND_TRANSPORT",
"GOBP_ORGANIC_ACID_TRANSPORT",
"GOBP_ORGANIC_ANION_TRANSPORT",
"GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_RENAL_SYSTEM_PROCESS",
"GOBP_RENAL_TUBULAR_SECRETION",
"GOBP_RESPONSE_TO_TOXIC_SUBSTANCE",
"GOBP_RIBOFLAVIN_TRANSPORT",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_SPHINGOLIPID_METABOLIC_PROCESS",
"GOBP_SULFUR_COMPOUND_TRANSPORT",
"GOBP_TRANSEPITHELIAL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOBP_URATE_METABOLIC_PROCESS",
"GOBP_URATE_TRANSPORT",
"GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM",
"GOBP_VASCULAR_TRANSPORT",
"GOBP_VITAMIN_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT",
"GOBP_XENOBIOTIC_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_BRUSH_BORDER",
"GOCC_BRUSH_BORDER_MEMBRANE",
"GOCC_CELL_PROJECTION_MEMBRANE",
"GOCC_CELL_SURFACE",
"GOCC_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS",
"GOCC_EXTERNAL_SIDE_OF_APICAL_PLASMA_MEMBRANE",
"GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE",
"GOCC_MEMBRANE_MICRODOMAIN",
"GOCC_MITOCHONDRIAL_ENVELOPE",
"GOCC_MITOCHONDRION",
"GOCC_ORGANELLE_ENVELOPE",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_SIDE_OF_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY",
"GOMF_RIBOFLAVIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SALT_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY",
"GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"HALLMARK_HEME_METABOLISM",
"KEGG_ABC_TRANSPORTERS",
"LTE2_UP.V1_UP",
"PID_HIF1_TFPATHWAY",
"PID_HIF2PATHWAY",
"RB_P130_DN.V1_DN",
"REACTOME_ABACAVIR_ADME",
"REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT",
"REACTOME_CELLULAR_RESPONSES_TO_STIMULI",
"REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS",
"REACTOME_CIPROFLOXACIN_ADME",
"REACTOME_DEVELOPMENTAL_CELL_LINEAGES",
"REACTOME_DIFFERENTIATION_OF_KERATINOCYTES_IN_INTERFOLLICULAR_EPIDERMIS_IN_MAMMALIAN_SKIN",
"REACTOME_DRUG_ADME",
"REACTOME_HEME_BIOSYNTHESIS",
"REACTOME_HEME_DEGRADATION",
"REACTOME_IRON_UPTAKE_AND_TRANSPORT",
"REACTOME_KEAP1_NFE2L2_PATHWAY",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_METABOLISM_OF_PORPHYRINS",
"REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES",
"REACTOME_NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2",
"REACTOME_PARACETAMOL_ADME",
"REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS",
"REACTOME_SPHINGOLIPID_METABOLISM",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_FLUOROPYRIMIDINE_ACTIVITY",
"WP_IMATINIB_AND_CHRONIC_MYELOID_LEUKEMIA",
"WP_IRINOTECAN_PATHWAY",
"WP_MIRTARGETED_GENES_IN_LYMPHOCYTES",
"WP_MIRTARGETED_GENES_IN_MUSCLE_CELL",
"WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING",
"WP_PROXIMAL_TUBULE_TRANSPORT"
] |
ABCG4
|
Q9H172
|
ATP-binding cassette sub-family G member 4
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15240127, PubMed:33141061). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (PubMed:27228027)
|
[
"ABC transporter",
"ABC transmembrane type-2"
] |
[
"ABCG1",
"GPR152",
"PLEKHF2",
"SGTB",
"TMEM50A",
"WFS1"
] |
[
"C:cytoplasmic vesicle",
"C:endosome membrane",
"C:plasma membrane",
"F:ABC-type sterol transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:identical protein binding",
"F:protein heterodimerization activity",
"F:protein homodimerization activity",
"P:cellular response to high density lipoprotein particle stimulus",
"P:cellular response to leukemia inhibitory factor",
"P:cholesterol efflux",
"P:cholesterol homeostasis",
"P:positive regulation of cholesterol biosynthetic process",
"P:positive regulation of cholesterol efflux",
"P:regulation of DNA-templated transcription",
"P:transmembrane transport"
] |
[
"CRX_NRL_DN.V1_UP",
"GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS",
"GOBP_ALCOHOL_METABOLIC_PROCESS",
"GOBP_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_POSITIVE_REGULATION_OF_TRANSPORT",
"GOBP_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX",
"GOBP_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_TRANSPORT",
"GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_STEROL_TRANSPORT",
"GOBP_REGULATION_OF_TRANSPORT",
"GOBP_RESPONSE_TO_LEUKEMIA_INHIBITORY_FACTOR",
"GOBP_RESPONSE_TO_PEPTIDE",
"GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_STEROID_BIOSYNTHETIC_PROCESS",
"GOBP_STEROID_METABOLIC_PROCESS",
"GOBP_STEROL_BIOSYNTHETIC_PROCESS",
"GOBP_STEROL_HOMEOSTASIS",
"GOBP_STEROL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"HALLMARK_KRAS_SIGNALING_DN",
"KEGG_ABC_TRANSPORTERS",
"KRAS.600_UP.V1_DN",
"KRAS.PROSTATE_UP.V1_DN",
"RB_P130_DN.V1_UP",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS"
] |
ABCG5
|
Q9H222
|
ATP-binding cassette sub-family G member 5
|
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11138003, PubMed:15054092, PubMed:27144356). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11138003, PubMed:15054092). The heterodimer with ABCG8 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356)
|
[
"ABC transporter",
"ABC transmembrane type-2"
] |
[
"ABCG8",
"NCK1",
"ABCG8"
] |
[
"C:apical plasma membrane",
"C:ATP-binding cassette (ABC) transporter complex",
"C:plasma membrane",
"C:receptor complex",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:cholesterol transfer activity",
"F:metal ion binding",
"F:protein heterodimerization activity",
"P:cholesterol efflux",
"P:cholesterol homeostasis",
"P:intestinal cholesterol absorption",
"P:negative regulation of intestinal cholesterol absorption",
"P:negative regulation of intestinal phytosterol absorption",
"P:response to ionizing radiation",
"P:response to muscle activity",
"P:response to nutrient",
"P:response to xenobiotic stimulus",
"P:sterol transport",
"P:transmembrane transport",
"P:triglyceride homeostasis"
] |
[
"ATM_DN.V1_UP",
"BIOCARTA_NUCLEARRS_PATHWAY",
"GOBP_ACYLGLYCEROL_HOMEOSTASIS",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_DIGESTION",
"GOBP_DIGESTIVE_SYSTEM_PROCESS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_INTESTINAL_ABSORPTION",
"GOBP_INTESTINAL_CHOLESTEROL_ABSORPTION",
"GOBP_INTESTINAL_LIPID_ABSORPTION",
"GOBP_LIPID_DIGESTION",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_INTESTINAL_ABSORPTION",
"GOBP_REGULATION_OF_INTESTINAL_CHOLESTEROL_ABSORPTION",
"GOBP_REGULATION_OF_INTESTINAL_LIPID_ABSORPTION",
"GOBP_REGULATION_OF_SYSTEM_PROCESS",
"GOBP_RESPONSE_TO_ABIOTIC_STIMULUS",
"GOBP_RESPONSE_TO_ACTIVITY",
"GOBP_RESPONSE_TO_IONIZING_RADIATION",
"GOBP_RESPONSE_TO_MUSCLE_ACTIVITY",
"GOBP_RESPONSE_TO_NUTRIENT",
"GOBP_RESPONSE_TO_NUTRIENT_LEVELS",
"GOBP_RESPONSE_TO_RADIATION",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_STEROL_HOMEOSTASIS",
"GOBP_STEROL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX",
"GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX",
"GOCC_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_RECEPTOR_COMPLEX",
"GOCC_TRANSPORTER_COMPLEX",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_CHOLESTEROL_TRANSFER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSFER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY",
"GOMF_STEROL_TRANSFER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"KEGG_ABC_TRANSPORTERS",
"KRAS.AMP.LUNG_UP.V1_UP",
"P53_DN.V2_DN",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING",
"REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX",
"REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY",
"WP_BILE_ACID_SYNTHESIS_AND_ENTEROHEPATIC_CIRCULATION",
"WP_CHOLESTASIS",
"WP_CHOLESTEROL_METABOLISM",
"WP_ENTEROCYTE_CHOLESTEROL_METABOLISM",
"WP_LIVER_X_RECEPTOR_PATHWAY",
"WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY",
"WP_NUCLEAR_RECEPTORS_METAPATHWAY",
"WP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION",
"WP_VITAMIN_A_AND_CAROTENOID_METABOLISM"
] |
ABCG8
|
Q9H221
|
ATP-binding cassette sub-family G member 8
|
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:15054092, PubMed:27144356). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356)
|
[
"ABC transporter",
"ABC transmembrane type-2"
] |
[
"ABCG5",
"MESD",
"ABCG5"
] |
[
"C:apical plasma membrane",
"C:ATP-binding cassette (ABC) transporter complex",
"C:plasma membrane",
"C:receptor complex",
"F:ABC-type transporter activity",
"F:ATP binding",
"F:ATP hydrolysis activity",
"F:ATPase-coupled transmembrane transporter activity",
"F:cholesterol transfer activity",
"F:metal ion binding",
"F:protein heterodimerization activity",
"P:cholesterol efflux",
"P:cholesterol homeostasis",
"P:intestinal cholesterol absorption",
"P:negative regulation of intestinal cholesterol absorption",
"P:negative regulation of intestinal phytosterol absorption",
"P:phospholipid transport",
"P:response to muscle activity",
"P:response to nutrient",
"P:response to xenobiotic stimulus",
"P:sterol transport",
"P:transmembrane transport",
"P:triglyceride homeostasis"
] |
[
"GOBP_ACYLGLYCEROL_HOMEOSTASIS",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CHOLESTEROL_EFFLUX",
"GOBP_DIGESTION",
"GOBP_DIGESTIVE_SYSTEM_PROCESS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_INTESTINAL_ABSORPTION",
"GOBP_INTESTINAL_CHOLESTEROL_ABSORPTION",
"GOBP_INTESTINAL_LIPID_ABSORPTION",
"GOBP_LIPID_DIGESTION",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT",
"GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT",
"GOBP_PHOSPHOLIPID_TRANSPORT",
"GOBP_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_INTESTINAL_ABSORPTION",
"GOBP_REGULATION_OF_INTESTINAL_CHOLESTEROL_ABSORPTION",
"GOBP_REGULATION_OF_INTESTINAL_LIPID_ABSORPTION",
"GOBP_REGULATION_OF_SYSTEM_PROCESS",
"GOBP_RESPONSE_TO_ACTIVITY",
"GOBP_RESPONSE_TO_MUSCLE_ACTIVITY",
"GOBP_RESPONSE_TO_NUTRIENT",
"GOBP_RESPONSE_TO_NUTRIENT_LEVELS",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_STEROL_HOMEOSTASIS",
"GOBP_STEROL_TRANSPORT",
"GOBP_TRANSMEMBRANE_TRANSPORT",
"GOCC_APICAL_PART_OF_CELL",
"GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX",
"GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX",
"GOCC_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_RECEPTOR_COMPLEX",
"GOCC_TRANSPORTER_COMPLEX",
"GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY",
"GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ADENYL_NUCLEOTIDE_BINDING",
"GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_ATP_DEPENDENT_ACTIVITY",
"GOMF_ATP_HYDROLYSIS_ACTIVITY",
"GOMF_CHOLESTEROL_TRANSFER_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES",
"GOMF_LIPID_TRANSFER_ACTIVITY",
"GOMF_LIPID_TRANSPORTER_ACTIVITY",
"GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY",
"GOMF_PROTEIN_DIMERIZATION_ACTIVITY",
"GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY",
"GOMF_STEROL_TRANSFER_ACTIVITY",
"GOMF_TRANSPORTER_ACTIVITY",
"HALLMARK_BILE_ACID_METABOLISM",
"KEGG_ABC_TRANSPORTERS",
"REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT",
"REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS",
"REACTOME_ABC_TRANSPORTER_DISORDERS",
"REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS",
"REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING",
"REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX",
"REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS",
"REACTOME_TRANSPORT_OF_SMALL_MOLECULES",
"WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY",
"WP_BILE_ACID_SYNTHESIS_AND_ENTEROHEPATIC_CIRCULATION",
"WP_CHOLESTASIS",
"WP_CHOLESTEROL_METABOLISM",
"WP_ENTEROCYTE_CHOLESTEROL_METABOLISM",
"WP_LIVER_X_RECEPTOR_PATHWAY",
"WP_NUCLEAR_RECEPTORS_METAPATHWAY",
"WP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION",
"WP_VITAMIN_A_AND_CAROTENOID_METABOLISM"
] |
ABHD1
|
Q96SE0
|
Protein ABHD1
|
[
"AB hydrolase-1"
] |
[
"KASH5"
] |
[
"C:membrane",
"F:acetylesterase activity",
"F:monoacylglycerol lipase activity",
"P:medium-chain fatty acid biosynthetic process",
"P:medium-chain fatty acid catabolic process"
] |
[
"CAHOY_ASTROCYTIC",
"GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MEDIUM_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_MEDIUM_CHAIN_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_MEDIUM_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOMF_ACETYLESTERASE_ACTIVITY",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY",
"GOMF_SHORT_CHAIN_CARBOXYLESTERASE_ACTIVITY"
] |
|
ABHD10
|
Q9NUJ1
|
Palmitoyl-protein thioesterase ABHD10, mitochondrial
|
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed:31740833). Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (PubMed:22294686)
|
[
"AB hydrolase-1"
] |
[
"HSPBAP1"
] |
[
"C:cytosol",
"C:mitochondrial matrix",
"C:mitochondrion",
"F:hydrolase activity, hydrolyzing O-glycosyl compounds",
"F:mycophenolic acid acyl-glucuronide esterase activity",
"F:palmitoyl-(protein) hydrolase activity",
"P:glucuronate metabolic process",
"P:protein depalmitoylation",
"P:xenobiotic metabolic process"
] |
[
"GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_LIPOPROTEIN_CATABOLIC_PROCESS",
"GOBP_LIPOPROTEIN_METABOLIC_PROCESS",
"GOBP_MACROMOLECULE_CATABOLIC_PROCESS",
"GOBP_MACROMOLECULE_DEACYLATION",
"GOBP_MACROMOLECULE_DEPALMITOYLATION",
"GOBP_PROTEIN_CATABOLIC_PROCESS",
"GOBP_PROTEIN_DEACYLATION",
"GOBP_PROTEIN_DEPALMITOYLATION",
"GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS",
"GOBP_XENOBIOTIC_METABOLIC_PROCESS",
"GOCC_MITOCHONDRIAL_MATRIX",
"GOCC_MITOCHONDRION",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS",
"GOMF_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS",
"GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY",
"GOMF_THIOLESTER_HYDROLASE_ACTIVITY",
"KRAS.DF.V1_UP",
"REACTOME_BIOLOGICAL_OXIDATIONS",
"REACTOME_GLUCURONIDATION",
"REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS",
"WP_MIRTARGETED_GENES_IN_LYMPHOCYTES",
"WP_MIRTARGETED_GENES_IN_MUSCLE_CELL"
] |
ABHD11
|
Q8NFV4
|
sn-1-specific diacylglycerol lipase ABHD11
|
Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol (PubMed:32579589). 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols (By similarity). The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts (PubMed:32792488). In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (By similarity)
|
[] |
[
"ANKRD11",
"CSTF2",
"DOK6",
"DTX2",
"FNDC3B",
"GCA",
"HR",
"MDFI",
"MORN3",
"PATZ1",
"PITX1",
"PRKAB2",
"PROP1",
"PRR35",
"RUSC1",
"USHBP1",
"VAC14",
"VENTX",
"VPS37C",
"WWOX",
"YTHDF1",
"ZIC1"
] |
[
"C:mitochondrial matrix",
"C:mitochondrion",
"C:oxoglutarate dehydrogenase complex",
"F:carboxylic ester hydrolase activity",
"F:lipase activity",
"P:lipid metabolic process"
] |
[
"GOBP_LIPID_METABOLIC_PROCESS",
"GOCC_ALPHA_KETOACID_DEHYDROGENASE_COMPLEX",
"GOCC_CATALYTIC_COMPLEX",
"GOCC_MITOCHONDRIAL_MATRIX",
"GOCC_MITOCHONDRION",
"GOCC_OXIDOREDUCTASE_COMPLEX",
"GOCC_OXOGLUTARATE_DEHYDROGENASE_COMPLEX",
"GOCC_TRICARBOXYLIC_ACID_CYCLE_HETEROMERIC_ENZYME_COMPLEX",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"WP_7Q1123_COPY_NUMBER_VARIATION_SYNDROME",
"WP_MIRTARGETED_GENES_IN_LYMPHOCYTES"
] |
ABHD12
|
Q8N2K0
|
Lysophosphatidylserine lipase ABHD12
|
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30643283, PubMed:30720278). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167)
|
[] |
[] |
[
"C:AMPA glutamate receptor complex",
"C:dendrite cytoplasm",
"C:endoplasmic reticulum membrane",
"C:membrane",
"C:plasma membrane",
"F:monoacylglycerol lipase activity",
"F:palmitoyl-(protein) hydrolase activity",
"F:phosphatidylcholine lysophospholipase activity",
"F:phosphatidylserine lysophospholipase activity",
"F:phospholipase activity",
"P:acylglycerol catabolic process",
"P:adult walking behavior",
"P:arachidonate metabolic process",
"P:glycerophospholipid catabolic process",
"P:monoacylglycerol catabolic process",
"P:phosphatidylserine catabolic process",
"P:phospholipid catabolic process",
"P:regulation of inflammatory response",
"P:response to auditory stimulus"
] |
[
"GOBP_ADULT_BEHAVIOR",
"GOBP_ADULT_LOCOMOTORY_BEHAVIOR",
"GOBP_ARACHIDONATE_METABOLIC_PROCESS",
"GOBP_BEHAVIOR",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_ICOSANOID_METABOLIC_PROCESS",
"GOBP_INFLAMMATORY_RESPONSE",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LOCOMOTORY_BEHAVIOR",
"GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_MACROMOLECULE_DEACYLATION",
"GOBP_MACROMOLECULE_DEPALMITOYLATION",
"GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS",
"GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS",
"GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDYLSERINE_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_REGULATION_OF_INFLAMMATORY_RESPONSE",
"GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_REGULATION_OF_RESPONSE_TO_STRESS",
"GOBP_RESPONSE_TO_ABIOTIC_STIMULUS",
"GOBP_RESPONSE_TO_AUDITORY_STIMULUS",
"GOBP_RESPONSE_TO_MECHANICAL_STIMULUS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_WALKING_BEHAVIOR",
"GOCC_AMPA_GLUTAMATE_RECEPTOR_COMPLEX",
"GOCC_CYTOPLASMIC_REGION",
"GOCC_DENDRITE_CYTOPLASM",
"GOCC_DENDRITIC_TREE",
"GOCC_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX",
"GOCC_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX",
"GOCC_NEURON_PROJECTION",
"GOCC_NEURON_PROJECTION_CYTOPLASM",
"GOCC_NEUROTRANSMITTER_RECEPTOR_COMPLEX",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_PLASMA_MEMBRANE_SIGNALING_RECEPTOR_COMPLEX",
"GOCC_RECEPTOR_COMPLEX",
"GOCC_SOMATODENDRITIC_COMPARTMENT",
"GOCC_TRANSPORTER_COMPLEX",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"GOMF_LYSOPHOSPHOLIPASE_ACTIVITY",
"GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY",
"GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY",
"GOMF_PHOSPHOLIPASE_ACTIVITY",
"GOMF_THIOLESTER_HYDROLASE_ACTIVITY",
"REACTOME_ARACHIDONATE_PRODUCTION_FROM_DAG",
"REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS",
"REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS",
"REACTOME_HEMOSTASIS",
"REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION",
"REACTOME_SIGNALING_BY_GPCR"
] |
ABHD12B
|
Q7Z5M8
|
Protein ABHD12B
|
[] |
[
"LAMP2",
"SH3GLB1"
] |
[
"C:endoplasmic reticulum membrane",
"F:monoacylglycerol lipase activity",
"F:phosphatidylcholine lysophospholipase activity",
"P:monoacylglycerol catabolic process",
"P:phosphatidylserine catabolic process"
] |
[
"GOBP_GLYCEROLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS",
"GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDYLSERINE_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"GOMF_LYSOPHOSPHOLIPASE_ACTIVITY",
"GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY",
"GOMF_PHOSPHOLIPASE_ACTIVITY"
] |
|
ABHD13
|
Q7L211
|
Protein ABHD13
|
[] |
[] |
[
"C:dendrite cytoplasm",
"C:membrane",
"F:palmitoyl-(protein) hydrolase activity"
] |
[
"GOBP_MACROMOLECULE_DEACYLATION",
"GOBP_MACROMOLECULE_DEPALMITOYLATION",
"GOCC_CYTOPLASMIC_REGION",
"GOCC_DENDRITE_CYTOPLASM",
"GOCC_DENDRITIC_TREE",
"GOCC_NEURON_PROJECTION",
"GOCC_NEURON_PROJECTION_CYTOPLASM",
"GOCC_SOMATODENDRITIC_COMPARTMENT",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY",
"GOMF_THIOLESTER_HYDROLASE_ACTIVITY"
] |
|
ABHD14A
|
Q9BUJ0
|
Protein ABHD14A
|
Possible role in granule neuron development
|
[] |
[] |
[
"C:cytoplasm",
"C:membrane",
"F:hydrolase activity"
] |
[
"AKT_UP_MTOR_DN.V1_DN",
"CRX_NRL_DN.V1_UP",
"SNF5_DN.V1_UP"
] |
ABHD14B
|
Q96IU4
|
Putative protein-lysine deacylase ABHD14B
|
Acts as an atypical protein-lysine deacetylase in vitro (PubMed:31478652). Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues (PubMed:31478652). Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo (Probable). Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate (PubMed:14672934, PubMed:31478652). May activate transcription (PubMed:14672934)
|
[] |
[] |
[
"C:cytoplasm",
"C:cytosol",
"C:extracellular exosome",
"C:nucleolus",
"C:nucleoplasm",
"C:nucleus",
"F:hydrolase activity",
"F:protein-lysine-acetyltransferase activity",
"P:3'-phosphoadenosine 5'-phosphosulfate metabolic process",
"P:positive regulation of transcription by RNA polymerase II"
] |
[
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_NUCLEOTIDE_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_RNA_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II",
"GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS",
"GOBP_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS",
"GOBP_RIBOSE_PHOSPHATE_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS",
"GOCC_NUCLEOLUS",
"GOMF_ACETYLTRANSFERASE_ACTIVITY",
"GOMF_ACYLTRANSFERASE_ACTIVITY",
"GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS",
"GOMF_N_ACETYLTRANSFERASE_ACTIVITY",
"GOMF_N_ACYLTRANSFERASE_ACTIVITY",
"GOMF_PROTEIN_N_ACETYLTRANSFERASE_ACTIVITY",
"KEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2",
"REACTOME_BIOLOGICAL_OXIDATIONS",
"REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES",
"REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS",
"STK33_DN",
"STK33_NOMO_DN",
"STK33_SKM_DN"
] |
ABHD15
|
Q6UXT9
|
Protein ABHD15
|
May regulate adipocyte lipolysis and liver lipid accumulation
|
[] |
[
"KRT34",
"MTUS2",
"SAT1",
"VWC2",
"WTAP"
] |
[
"C:extracellular region",
"C:membrane",
"F:monoacylglycerol lipase activity",
"F:short-chain carboxylesterase activity",
"P:adipose tissue development",
"P:lipid catabolic process",
"P:lipid metabolic process"
] |
[
"E2F3_UP.V1_UP",
"GOBP_ADIPOSE_TISSUE_DEVELOPMENT",
"GOBP_CONNECTIVE_TISSUE_DEVELOPMENT",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY",
"GOMF_SHORT_CHAIN_CARBOXYLESTERASE_ACTIVITY"
] |
ABHD16A
|
O95870
|
Phosphatidylserine lipase ABHD16A
|
Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914)
|
[
"AB hydrolase-1"
] |
[
"AGPAT3",
"AQP6",
"AQP7",
"ATP5PF",
"BRI3",
"CBARP",
"CIDEB",
"CYP1A2",
"DTX2",
"EBP",
"ERGIC3",
"FDPS",
"FKBP7",
"GDAP1",
"GJA5",
"GOLT1A",
"GORAB",
"GPR152",
"GYPC",
"HSD17B13",
"IFITM3",
"ITGAM",
"LTA",
"PERP",
"PKMYT1",
"POLE",
"PRAF2",
"RETREG3",
"RHBDD2",
"RHBDL1",
"RNF5",
"SEC22B",
"SERF1B",
"SLC10A1",
"SLC30A2",
"SLC7A8",
"SPAG4",
"STMN4",
"STX1B",
"TM4SF19",
"TMEM139",
"TMEM143",
"TMEM147",
"TMEM14B",
"TMEM237",
"TMEM65",
"TSPAN2",
"UNC93A",
"VAMP5",
"VMA21",
"WBP1L",
"6"
] |
[
"C:membrane",
"F:monoacylglycerol lipase activity",
"F:phospholipase activity",
"P:monoacylglycerol catabolic process",
"P:phosphatidylserine catabolic process",
"P:prostaglandin catabolic process"
] |
[
"GOBP_FATTY_ACID_DERIVATIVE_CATABOLIC_PROCESS",
"GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_ICOSANOID_CATABOLIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS",
"GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDYLSERINE_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"GOMF_LYSOPHOSPHOLIPASE_ACTIVITY",
"GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY",
"GOMF_PHOSPHOLIPASE_ACTIVITY",
"WP_IL18_SIGNALING"
] |
ABHD16B
|
Q9H3Z7
|
ABHD16B
|
Hydrolyzes the sn-1 position of glycerophospholipids with high specificity towards phosphatidylserine (PS), PS-PLA1 enzyme (PubMed:36841071). Also hydrolyzes the acyl chain of glycerolipids with a preference for the monoacylglycerol (MAG) 1-acylglycerol, MAG lipase (PubMed:36841071). Plays a regulatory role in cellular lipid homeostasis by modulating genes involved in neutral lipid degradation and in phospholipid synthesis and composition (PubMed:37944658)
|
[
"AB hydrolase-1"
] |
[] |
[
"C:nucleoplasm",
"F:monoacylglycerol lipase activity",
"F:phospholipase activity",
"P:monoacylglycerol catabolic process",
"P:phosphatidylserine catabolic process"
] |
[
"GOBP_GLYCEROLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS",
"GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS",
"GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS",
"GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDYLSERINE_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY",
"GOMF_PHOSPHOLIPASE_ACTIVITY"
] |
ABHD17A
|
Q96GS6
|
Alpha/beta hydrolase domain-containing protein 17A
|
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards NRAS (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). May have depalmitoylating activity towards MAP6 (By similarity)
|
[] |
[
"HPGDS",
"Hoxa1"
] |
[
"C:dendritic spine",
"C:endosome membrane",
"C:glutamatergic synapse",
"C:membrane",
"C:nuclear speck",
"C:plasma membrane",
"C:postsynaptic density membrane",
"C:postsynaptic recycling endosome membrane",
"C:recycling endosome membrane",
"F:palmitoyl-(protein) hydrolase activity",
"P:negative regulation of NLRP3 inflammasome complex assembly",
"P:negative regulation of protein localization to microtubule",
"P:positive regulation of protein localization to endosome",
"P:protein depalmitoylation",
"P:protein localization to membrane",
"P:regulation of postsynapse organization"
] |
[
"GOBP_ACTIVATION_OF_IMMUNE_RESPONSE",
"GOBP_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE",
"GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS",
"GOBP_CELL_JUNCTION_ORGANIZATION",
"GOBP_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM",
"GOBP_DEFENSE_RESPONSE_TO_SYMBIONT",
"GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY",
"GOBP_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY",
"GOBP_INFLAMMATORY_RESPONSE",
"GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_LIPOPROTEIN_CATABOLIC_PROCESS",
"GOBP_LIPOPROTEIN_METABOLIC_PROCESS",
"GOBP_LOCALIZATION_WITHIN_MEMBRANE",
"GOBP_MACROMOLECULE_CATABOLIC_PROCESS",
"GOBP_MACROMOLECULE_DEACYLATION",
"GOBP_MACROMOLECULE_DEPALMITOYLATION",
"GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_NEGATIVE_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY",
"GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION",
"GOBP_NEGATIVE_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MICROTUBULE",
"GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS",
"GOBP_NEGATIVE_REGULATION_OF_SIGNALING",
"GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE",
"GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS",
"GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_POSTSYNAPSE_ORGANIZATION",
"GOBP_PROTEIN_CATABOLIC_PROCESS",
"GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION",
"GOBP_PROTEIN_DEACYLATION",
"GOBP_PROTEIN_DEPALMITOYLATION",
"GOBP_PROTEIN_LOCALIZATION_TO_CYTOSKELETON",
"GOBP_PROTEIN_LOCALIZATION_TO_ENDOSOME",
"GOBP_PROTEIN_LOCALIZATION_TO_MICROTUBULE",
"GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE",
"GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_REGULATION_OF_IMMUNE_RESPONSE",
"GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE",
"GOBP_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_POSTSYNAPSE_ORGANIZATION",
"GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY",
"GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_ENDOSOME",
"GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS",
"GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_REGULATION_OF_RESPONSE_TO_STRESS",
"GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY",
"GOBP_SYNAPSE_ORGANIZATION",
"GOCC_DENDRITIC_TREE",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_GLUTAMATERGIC_SYNAPSE",
"GOCC_NEURON_PROJECTION",
"GOCC_NEURON_SPINE",
"GOCC_NEURON_TO_NEURON_SYNAPSE",
"GOCC_NUCLEAR_BODY",
"GOCC_NUCLEAR_SPECK",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_POSTSYNAPSE",
"GOCC_POSTSYNAPTIC_DENSITY_MEMBRANE",
"GOCC_POSTSYNAPTIC_ENDOSOME",
"GOCC_POSTSYNAPTIC_ENDOSOME_MEMBRANE",
"GOCC_POSTSYNAPTIC_MEMBRANE",
"GOCC_POSTSYNAPTIC_RECYCLING_ENDOSOME",
"GOCC_POSTSYNAPTIC_RECYCLING_ENDOSOME_MEMBRANE",
"GOCC_POSTSYNAPTIC_SPECIALIZATION",
"GOCC_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE",
"GOCC_RECYCLING_ENDOSOME",
"GOCC_RECYCLING_ENDOSOME_MEMBRANE",
"GOCC_SOMATODENDRITIC_COMPARTMENT",
"GOCC_SYNAPSE",
"GOCC_SYNAPTIC_MEMBRANE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY",
"GOMF_THIOLESTER_HYDROLASE_ACTIVITY",
"REACTOME_MAPK1_MAPK3_SIGNALING",
"REACTOME_MAPK_FAMILY_SIGNALING_CASCADES",
"REACTOME_RAS_PROCESSING"
] |
ABHD17B
|
Q5VST6
|
Alpha/beta hydrolase domain-containing protein 17B
|
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913)
|
[] |
[] |
[
"C:dendritic spine",
"C:endosome membrane",
"C:glutamatergic synapse",
"C:membrane",
"C:plasma membrane",
"C:postsynaptic density membrane",
"C:postsynaptic recycling endosome membrane",
"C:recycling endosome membrane",
"F:palmitoyl-(protein) hydrolase activity",
"P:negative regulation of protein localization to microtubule",
"P:positive regulation of protein localization to endosome",
"P:protein depalmitoylation",
"P:regulation of dendritic spine maintenance",
"P:regulation of postsynapse organization",
"P:regulation of protein localization to synapse"
] |
[
"GOBP_CELLULAR_COMPONENT_MAINTENANCE",
"GOBP_CELL_JUNCTION_ORGANIZATION",
"GOBP_CELL_PROJECTION_ORGANIZATION",
"GOBP_DENDRITIC_SPINE_MAINTENANCE",
"GOBP_LIPOPROTEIN_CATABOLIC_PROCESS",
"GOBP_LIPOPROTEIN_METABOLIC_PROCESS",
"GOBP_MACROMOLECULE_CATABOLIC_PROCESS",
"GOBP_MACROMOLECULE_DEACYLATION",
"GOBP_MACROMOLECULE_DEPALMITOYLATION",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MICROTUBULE",
"GOBP_NEURON_PROJECTION_ORGANIZATION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_POSTSYNAPSE_ORGANIZATION",
"GOBP_PROTEIN_CATABOLIC_PROCESS",
"GOBP_PROTEIN_DEACYLATION",
"GOBP_PROTEIN_DEPALMITOYLATION",
"GOBP_PROTEIN_LOCALIZATION_TO_CELL_JUNCTION",
"GOBP_PROTEIN_LOCALIZATION_TO_CYTOSKELETON",
"GOBP_PROTEIN_LOCALIZATION_TO_ENDOSOME",
"GOBP_PROTEIN_LOCALIZATION_TO_MICROTUBULE",
"GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE",
"GOBP_PROTEIN_LOCALIZATION_TO_SYNAPSE",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION",
"GOBP_REGULATION_OF_DENDRITIC_SPINE_MAINTENANCE",
"GOBP_REGULATION_OF_POSTSYNAPSE_ORGANIZATION",
"GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_ENDOSOME",
"GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_SYNAPSE",
"GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY",
"GOBP_SYNAPSE_ORGANIZATION",
"GOCC_DENDRITIC_TREE",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_GLUTAMATERGIC_SYNAPSE",
"GOCC_NEURON_PROJECTION",
"GOCC_NEURON_SPINE",
"GOCC_NEURON_TO_NEURON_SYNAPSE",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_POSTSYNAPSE",
"GOCC_POSTSYNAPTIC_DENSITY_MEMBRANE",
"GOCC_POSTSYNAPTIC_ENDOSOME",
"GOCC_POSTSYNAPTIC_ENDOSOME_MEMBRANE",
"GOCC_POSTSYNAPTIC_MEMBRANE",
"GOCC_POSTSYNAPTIC_RECYCLING_ENDOSOME",
"GOCC_POSTSYNAPTIC_RECYCLING_ENDOSOME_MEMBRANE",
"GOCC_POSTSYNAPTIC_SPECIALIZATION",
"GOCC_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE",
"GOCC_RECYCLING_ENDOSOME",
"GOCC_RECYCLING_ENDOSOME_MEMBRANE",
"GOCC_SOMATODENDRITIC_COMPARTMENT",
"GOCC_SYNAPSE",
"GOCC_SYNAPTIC_MEMBRANE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY",
"GOMF_THIOLESTER_HYDROLASE_ACTIVITY",
"REACTOME_MAPK1_MAPK3_SIGNALING",
"REACTOME_MAPK_FAMILY_SIGNALING_CASCADES",
"REACTOME_RAS_PROCESSING"
] |
ABHD17C
|
Q6PCB6
|
Alpha/beta hydrolase domain-containing protein 17C
|
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95
|
[] |
[
"A2M",
"APBB2",
"ATXN3",
"DNM2",
"HTT",
"MECP2",
"OPTN",
"PEX26",
"PHYH",
"PMP22",
"SMN2",
"SNCA",
"TOR1A",
"TOR1A"
] |
[
"C:dendritic spine",
"C:endosome membrane",
"C:glutamatergic synapse",
"C:plasma membrane",
"C:postsynaptic density membrane",
"C:recycling endosome membrane",
"F:palmitoyl-(protein) hydrolase activity",
"P:negative regulation of protein localization to microtubule",
"P:positive regulation of protein localization to endosome",
"P:protein depalmitoylation",
"P:regulation of postsynapse organization"
] |
[
"GOBP_CELL_JUNCTION_ORGANIZATION",
"GOBP_LIPOPROTEIN_CATABOLIC_PROCESS",
"GOBP_LIPOPROTEIN_METABOLIC_PROCESS",
"GOBP_MACROMOLECULE_CATABOLIC_PROCESS",
"GOBP_MACROMOLECULE_DEACYLATION",
"GOBP_MACROMOLECULE_DEPALMITOYLATION",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MICROTUBULE",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION",
"GOBP_POSTSYNAPSE_ORGANIZATION",
"GOBP_PROTEIN_CATABOLIC_PROCESS",
"GOBP_PROTEIN_DEACYLATION",
"GOBP_PROTEIN_DEPALMITOYLATION",
"GOBP_PROTEIN_LOCALIZATION_TO_CYTOSKELETON",
"GOBP_PROTEIN_LOCALIZATION_TO_ENDOSOME",
"GOBP_PROTEIN_LOCALIZATION_TO_MICROTUBULE",
"GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE",
"GOBP_REGULATION_OF_CELLULAR_LOCALIZATION",
"GOBP_REGULATION_OF_POSTSYNAPSE_ORGANIZATION",
"GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_ENDOSOME",
"GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY",
"GOBP_SYNAPSE_ORGANIZATION",
"GOCC_DENDRITIC_TREE",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_GLUTAMATERGIC_SYNAPSE",
"GOCC_NEURON_PROJECTION",
"GOCC_NEURON_SPINE",
"GOCC_NEURON_TO_NEURON_SYNAPSE",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_POSTSYNAPSE",
"GOCC_POSTSYNAPTIC_DENSITY_MEMBRANE",
"GOCC_POSTSYNAPTIC_MEMBRANE",
"GOCC_POSTSYNAPTIC_SPECIALIZATION",
"GOCC_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE",
"GOCC_RECYCLING_ENDOSOME",
"GOCC_RECYCLING_ENDOSOME_MEMBRANE",
"GOCC_SOMATODENDRITIC_COMPARTMENT",
"GOCC_SYNAPSE",
"GOCC_SYNAPTIC_MEMBRANE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY",
"GOMF_THIOLESTER_HYDROLASE_ACTIVITY",
"REACTOME_MAPK1_MAPK3_SIGNALING",
"REACTOME_MAPK_FAMILY_SIGNALING_CASCADES",
"REACTOME_RAS_PROCESSING"
] |
ABHD18
|
Q0P651
|
Protein ABHD18
|
[] |
[] |
[
"C:extracellular region",
"C:mitochondrion"
] |
[
"GOCC_MITOCHONDRION",
"JAK2_DN.V1_DN"
] |
|
ABHD2
|
P08910
|
Monoacylglycerol lipase ABHD2
|
Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity)
|
[
"AB hydrolase-1"
] |
[] |
[
"C:acrosomal vesicle",
"C:sperm flagellum",
"C:sperm plasma membrane",
"F:acetylesterase activity",
"F:diacylglycerol lipase activity",
"F:hormone binding",
"F:monoacylglycerol lipase activity",
"F:nuclear steroid receptor activity",
"F:triacylglycerol lipase activity",
"P:acrosome reaction",
"P:acylglycerol catabolic process",
"P:medium-chain fatty acid biosynthetic process",
"P:medium-chain fatty acid catabolic process",
"P:negative regulation of smooth muscle cell migration",
"P:response to progesterone",
"P:response to wounding",
"P:smooth muscle cell migration",
"P:sperm capacitation",
"P:steroid hormone receptor signaling pathway"
] |
[
"GOBP_ACROSOME_REACTION",
"GOBP_ANATOMICAL_STRUCTURE_MATURATION",
"GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM",
"GOBP_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS",
"GOBP_CELLULAR_RESPONSE_TO_LIPID",
"GOBP_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS",
"GOBP_CELL_MATURATION",
"GOBP_CELL_MOTILITY",
"GOBP_DEVELOPMENTAL_MATURATION",
"GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION",
"GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_FERTILIZATION",
"GOBP_GAMETE_GENERATION",
"GOBP_GLYCEROLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_HORMONE_MEDIATED_SIGNALING_PATHWAY",
"GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LOCOMOTION",
"GOBP_MALE_GAMETE_GENERATION",
"GOBP_MEDIUM_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_MEDIUM_CHAIN_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_MEDIUM_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_MULTICELLULAR_ORGANISMAL_REPRODUCTIVE_PROCESS",
"GOBP_MUSCLE_CELL_MIGRATION",
"GOBP_NEGATIVE_REGULATION_OF_LOCOMOTION",
"GOBP_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION",
"GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS",
"GOBP_NUCLEAR_RECEPTOR_MEDIATED_SIGNALING_PATHWAY",
"GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LOCOMOTION",
"GOBP_REPRODUCTIVE_PROCESS",
"GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS",
"GOBP_RESPONSE_TO_HORMONE",
"GOBP_RESPONSE_TO_KETONE",
"GOBP_RESPONSE_TO_LIPID",
"GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND",
"GOBP_RESPONSE_TO_PROGESTERONE",
"GOBP_RESPONSE_TO_STEROID_HORMONE",
"GOBP_RESPONSE_TO_WOUNDING",
"GOBP_SEXUAL_REPRODUCTION",
"GOBP_SINGLE_FERTILIZATION",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_SMOOTH_MUSCLE_CELL_MIGRATION",
"GOBP_SPERMATID_DIFFERENTIATION",
"GOBP_SPERM_CAPACITATION",
"GOBP_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY",
"GOCC_9PLUS2_MOTILE_CILIUM",
"GOCC_ACROSOMAL_VESICLE",
"GOCC_CILIUM",
"GOCC_MOTILE_CILIUM",
"GOCC_SECRETORY_GRANULE",
"GOCC_SECRETORY_VESICLE",
"GOCC_SPERM_PLASMA_MEMBRANE",
"GOMF_ACETYLESTERASE_ACTIVITY",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY",
"GOMF_HORMONE_BINDING",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIGAND_MODULATED_TRANSCRIPTION_FACTOR_ACTIVITY",
"GOMF_LIPASE_ACTIVITY",
"GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY",
"GOMF_NUCLEAR_STEROID_RECEPTOR_ACTIVITY",
"GOMF_SHORT_CHAIN_CARBOXYLESTERASE_ACTIVITY",
"GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY",
"GOMF_TRIACYLGLYCEROL_LIPASE_ACTIVITY",
"HALLMARK_ANDROGEN_RESPONSE",
"HALLMARK_ESTROGEN_RESPONSE_EARLY",
"HALLMARK_ESTROGEN_RESPONSE_LATE",
"JNK_DN.V1_DN",
"STK33_NOMO_UP",
"STK33_UP",
"WP_GLUCOCORTICOID_RECEPTOR_PATHWAY",
"WP_NUCLEAR_RECEPTORS_METAPATHWAY"
] |
ABHD3
|
Q8WU67
|
Phospholipase ABHD3
|
Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids
|
[
"AB hydrolase-1"
] |
[] |
[
"C:plasma membrane",
"F:acetylesterase activity",
"F:monoacylglycerol lipase activity",
"F:phospholipase A1 activity",
"F:phospholipase A2 activity",
"P:medium-chain fatty acid biosynthetic process",
"P:medium-chain fatty acid catabolic process",
"P:phosphatidylcholine biosynthetic process",
"P:phosphatidylcholine metabolic process"
] |
[
"GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MEDIUM_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_MEDIUM_CHAIN_FATTY_ACID_CATABOLIC_PROCESS",
"GOBP_MEDIUM_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANIC_ACID_CATABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS",
"GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS",
"GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOMF_ACETYLESTERASE_ACTIVITY",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY",
"GOMF_PHOSPHOLIPASE_A1_ACTIVITY",
"GOMF_PHOSPHOLIPASE_A2_ACTIVITY",
"GOMF_PHOSPHOLIPASE_ACTIVITY",
"GOMF_SHORT_CHAIN_CARBOXYLESTERASE_ACTIVITY",
"MYC_UP.V1_DN",
"NRL_DN.V1_DN",
"REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_PHOSPHOLIPID_METABOLISM",
"REACTOME_SYNTHESIS_OF_PC",
"SRC_UP.V1_DN",
"VEGF_A_UP.V1_UP"
] |
ABHD4
|
Q8TB40
|
(Lyso)-N-acylphosphatidylethanolamine lipase
|
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine
|
[
"AB hydrolase-1"
] |
[
"AURKAIP1",
"BNIP2",
"CMTM5",
"COL4A5",
"DERL1",
"DGAT2L6",
"HTATIP2",
"IGFBP5",
"INSIG2",
"PLIN3",
"RABAC1",
"REEP5"
] |
[
"C:endoplasmic reticulum membrane",
"C:lipid droplet",
"F:hydrolase activity",
"F:lysophosphatidic acid acyltransferase activity",
"F:phosphatidylcholine lysophospholipase activity",
"P:lipid catabolic process",
"P:lipid homeostasis",
"P:N-acylphosphatidylethanolamine metabolic process",
"P:phosphatidic acid biosynthetic process",
"P:phosphatidylethanolamine acyl-chain remodeling"
] |
[
"GOBP_AMIDE_METABOLIC_PROCESS",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_N_ACYLPHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDIC_ACID_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING",
"GOBP_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOCC_LIPID_DROPLET",
"GOCC_MITOCHONDRION",
"GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK",
"GOCC_ORGANELLE_SUBCOMPARTMENT",
"GOMF_ACYLTRANSFERASE_ACTIVITY",
"GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"GOMF_LYSOPHOSPHOLIPASE_ACTIVITY",
"GOMF_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY",
"GOMF_PHOSPHOLIPASE_ACTIVITY",
"HALLMARK_P53_PATHWAY",
"NFE2L2.V2",
"REACTOME_ACYL_CHAIN_REMODELLING_OF_PE",
"REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_PHOSPHOLIPID_METABOLISM"
] |
ABHD5
|
Q8WTS1
|
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
|
Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid (PubMed:18606822). Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity)
|
[
"AB hydrolase-1"
] |
[
"CERCAM",
"CLCN4",
"COQ8A",
"DGAT2L6",
"GAD2",
"GET1",
"GRIA4",
"MIEF1",
"PCNX2",
"PLIN2",
"PLIN3",
"PLIN5",
"RBFA",
"RNF24",
"RUSC1",
"SH3GLB1",
"SLC44A3",
"TMEM14B",
"TPD52L2",
"ZCCHC12"
] |
[
"C:cytosol",
"C:lipid droplet",
"C:nucleoplasm",
"F:1-acylglycerol-3-phosphate O-acyltransferase activity",
"F:carboxylic ester hydrolase activity",
"F:lipase activator activity",
"F:lysophosphatidic acid acyltransferase activity",
"P:cell differentiation",
"P:fatty acid metabolic process",
"P:lipid homeostasis",
"P:negative regulation of triglyceride storage",
"P:phosphatidic acid biosynthetic process",
"P:positive regulation of triglyceride catabolic process"
] |
[
"ESC_J1_UP_LATE.V1_UP",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCEROLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_LOCALIZATION",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_NEGATIVE_REGULATION_OF_LIPID_STORAGE",
"GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS",
"GOBP_NUTRIENT_STORAGE",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDIC_ACID_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_LOCALIZATION",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_STORAGE",
"GOBP_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS",
"GOBP_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_TRIGLYCERIDE_CATABOLIC_PROCESS",
"GOBP_TRIGLYCERIDE_METABOLIC_PROCESS",
"GOBP_TRIGLYCERIDE_STORAGE",
"GOCC_LIPID_DROPLET",
"GOCC_MITOCHONDRION",
"GOMF_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY",
"GOMF_ACYLTRANSFERASE_ACTIVITY",
"GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_ENZYME_ACTIVATOR_ACTIVITY",
"GOMF_ENZYME_REGULATOR_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVATOR_ACTIVITY",
"GOMF_LIPASE_ACTIVITY",
"GOMF_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY",
"GOMF_MOLECULAR_FUNCTION_ACTIVATOR_ACTIVITY",
"GOMF_O_ACYLTRANSFERASE_ACTIVITY",
"GOMF_TRIACYLGLYCEROL_LIPASE_ACTIVITY",
"REACTOME_METABOLISM_OF_LIPIDS",
"REACTOME_TRIGLYCERIDE_CATABOLISM",
"REACTOME_TRIGLYCERIDE_METABOLISM",
"WP_5Q35_COPY_NUMBER_VARIATION",
"WP_LIPID_METABOLISM_PATHWAY"
] |
ABHD6
|
Q9BV23
|
Monoacylglycerol lipase ABHD6
|
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015)
|
[
"AB hydrolase-1"
] |
[
"FIS1",
"RTP2",
"SCAMP4",
"TVP23B"
] |
[
"C:AMPA glutamate receptor complex",
"C:GABA-ergic synapse",
"C:glutamatergic synapse",
"C:late endosome membrane",
"C:lysosomal membrane",
"C:membrane",
"C:mitochondrial membrane",
"C:plasma membrane",
"C:postsynaptic membrane",
"F:monoacylglycerol lipase activity",
"F:phospholipase activity",
"P:acylglycerol catabolic process",
"P:arachidonate metabolic process",
"P:long-term synaptic depression",
"P:lysobisphosphatidic acid metabolic process",
"P:monoacylglycerol catabolic process",
"P:negative regulation of cell migration",
"P:negative regulation of cold-induced thermogenesis",
"P:phospholipid catabolic process",
"P:positive regulation of lipid biosynthetic process",
"P:regulation of endocannabinoid signaling pathway",
"P:regulation of retrograde trans-synaptic signaling by endocanabinoid"
] |
[
"GOBP_ADAPTIVE_THERMOGENESIS",
"GOBP_ALDITOL_PHOSPHATE_METABOLIC_PROCESS",
"GOBP_ARACHIDONATE_METABOLIC_PROCESS",
"GOBP_CANNABINOID_SIGNALING_PATHWAY",
"GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS",
"GOBP_CELL_CELL_SIGNALING",
"GOBP_CELL_MOTILITY",
"GOBP_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_CATABOLIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_ICOSANOID_METABOLIC_PROCESS",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_CATABOLIC_PROCESS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_LOCOMOTION",
"GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS",
"GOBP_LONG_TERM_SYNAPTIC_DEPRESSION",
"GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS",
"GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS",
"GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS",
"GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS",
"GOBP_NEGATIVE_REGULATION_OF_COLD_INDUCED_THERMOGENESIS",
"GOBP_NEGATIVE_REGULATION_OF_LOCOMOTION",
"GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_SIGNALING",
"GOBP_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION",
"GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS",
"GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS",
"GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS",
"GOBP_ORGANIC_ACID_METABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_LOCOMOTION",
"GOBP_REGULATION_OF_SYNAPTIC_PLASTICITY",
"GOBP_REGULATION_OF_TRANS_SYNAPTIC_SIGNALING",
"GOBP_RETROGRADE_TRANS_SYNAPTIC_SIGNALING",
"GOBP_RETROGRADE_TRANS_SYNAPTIC_SIGNALING_BY_LIPID",
"GOBP_SMALL_MOLECULE_METABOLIC_PROCESS",
"GOBP_SYNAPTIC_SIGNALING",
"GOBP_TEMPERATURE_HOMEOSTASIS",
"GOBP_TRANS_SYNAPTIC_SIGNALING_BY_LIPID",
"GOBP_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS",
"GOCC_AMPA_GLUTAMATE_RECEPTOR_COMPLEX",
"GOCC_ENDOSOME",
"GOCC_ENDOSOME_MEMBRANE",
"GOCC_GABA_ERGIC_SYNAPSE",
"GOCC_GLUTAMATERGIC_SYNAPSE",
"GOCC_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX",
"GOCC_LATE_ENDOSOME",
"GOCC_LATE_ENDOSOME_MEMBRANE",
"GOCC_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_MITOCHONDRIAL_ENVELOPE",
"GOCC_MITOCHONDRION",
"GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX",
"GOCC_NEUROTRANSMITTER_RECEPTOR_COMPLEX",
"GOCC_ORGANELLE_ENVELOPE",
"GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX",
"GOCC_PLASMA_MEMBRANE_REGION",
"GOCC_PLASMA_MEMBRANE_SIGNALING_RECEPTOR_COMPLEX",
"GOCC_POSTSYNAPSE",
"GOCC_POSTSYNAPTIC_MEMBRANE",
"GOCC_RECEPTOR_COMPLEX",
"GOCC_SYNAPSE",
"GOCC_SYNAPTIC_MEMBRANE",
"GOCC_TRANSPORTER_COMPLEX",
"GOCC_VACUOLAR_MEMBRANE",
"GOCC_VACUOLE",
"GOCC_VESICLE_MEMBRANE",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LIPASE_ACTIVITY",
"GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY",
"GOMF_PHOSPHOLIPASE_ACTIVITY",
"HALLMARK_XENOBIOTIC_METABOLISM",
"MTOR_UP.N4.V1_UP",
"RAF_UP.V1_UP",
"REACTOME_ARACHIDONATE_PRODUCTION_FROM_DAG",
"REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS",
"REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS",
"REACTOME_HEMOSTASIS",
"REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION",
"REACTOME_SIGNALING_BY_GPCR"
] |
ABHD8
|
Q96I13
|
Protein ABHD8
|
Negatively regulates NLRP3-driven inflammation (PubMed:39225180). Promotes NLRP3 degradation through the chaperone-mediated autophagy (CMA) pathway, hence attenuating inflammasome activation and IL1B secretion. Acts by recruiting palmitoyltransferase ZDHHC12 to NLRP3, facilitating NLRP3 palmitoylation and subsequent degradation (PubMed:39225180)
|
[
"AB hydrolase-1"
] |
[
"FNDC3B",
"ZNF410"
] |
[
"C:cytoplasm",
"C:extracellular exosome",
"F:carboxylic ester hydrolase activity",
"F:lysophosphatidic acid acyltransferase activity",
"P:inflammatory response",
"P:lipid homeostasis",
"P:negative regulation of NLRP3 inflammasome complex assembly",
"P:phosphatidic acid biosynthetic process"
] |
[
"ALK_DN.V1_DN",
"ATF2_S_UP.V1_DN",
"BMI1_DN.V1_DN",
"CAHOY_OLIGODENDROCUTIC",
"GOBP_ACTIVATION_OF_IMMUNE_RESPONSE",
"GOBP_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE",
"GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS",
"GOBP_CHEMICAL_HOMEOSTASIS",
"GOBP_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM",
"GOBP_DEFENSE_RESPONSE_TO_SYMBIONT",
"GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCEROLIPID_METABOLIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_HOMEOSTATIC_PROCESS",
"GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY",
"GOBP_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY",
"GOBP_INFLAMMATORY_RESPONSE",
"GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_LIPID_BIOSYNTHETIC_PROCESS",
"GOBP_LIPID_HOMEOSTASIS",
"GOBP_LIPID_METABOLIC_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION",
"GOBP_NEGATIVE_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_NEGATIVE_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY",
"GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION",
"GOBP_NEGATIVE_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY",
"GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY",
"GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS",
"GOBP_NEGATIVE_REGULATION_OF_SIGNALING",
"GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS",
"GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS",
"GOBP_PHOSPHATIDIC_ACID_METABOLIC_PROCESS",
"GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS",
"GOBP_PHOSPHOLIPID_METABOLIC_PROCESS",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE",
"GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS",
"GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION",
"GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS",
"GOBP_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_DEFENSE_RESPONSE",
"GOBP_REGULATION_OF_IMMUNE_RESPONSE",
"GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS",
"GOBP_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE",
"GOBP_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY",
"GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY",
"GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS",
"GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS",
"GOBP_REGULATION_OF_RESPONSE_TO_STRESS",
"GOCC_MITOCHONDRION",
"GOMF_ACYLTRANSFERASE_ACTIVITY",
"GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS",
"GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY",
"GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS",
"GOMF_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY",
"KRAS.PROSTATE_UP.V1_UP"
] |
ABI1
|
Q8IZP0
|
Abl interactor 1
|
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons
|
[
"t-SNARE coiled-coil homology",
"SH3"
] |
[
"ABL1",
"ABL2",
"BAIAP2",
"CACNA1A",
"CBLB",
"CYFIP1",
"CYFIP2",
"HSPA8",
"NCF1",
"NCK1",
"NCKAP1",
"PIK3R1",
"PIK3R3",
"RASA1",
"SOCS7",
"SOS1",
"SPTA1",
"VAV1",
"VAV2",
"WASF1",
"WASF2",
"Eps8",
"Pik3r1",
"CBL",
"ITGA4",
"Abl1",
"ABI2",
"C22orf15",
"CCDC57",
"CCHCR1",
"DTNB",
"EIF3H",
"ENKD1",
"FAM124B",
"FBXL19",
"FHL2",
"HHEX",
"HNRNPK",
"HOMER1",
"HOMER3",
"KIAA1217",
"LMO1",
"MAB21L2",
"NFASC",
"NHSL2",
"PRKAA2",
"RBM15",
"RCOR3",
"SMARCD1",
"SORBS2",
"TRIP10",
"TTC23",
"VARS2",
"VASP"
] |
[
"C:actin-based cell projection",
"C:cytoskeleton",
"C:cytosol",
"C:endoplasmic reticulum",
"C:extracellular exosome",
"C:filopodium tip",
"C:growth cone",
"C:lamellipodium",
"C:nucleus",
"C:postsynaptic density",
"C:SCAR complex",
"F:cadherin binding",
"F:cytoskeletal protein binding",
"F:protein tyrosine kinase activator activity",
"F:SH3 domain binding",
"F:signaling adaptor activity",
"P:actin polymerization or depolymerization",
"P:cell projection morphogenesis",
"P:cell surface receptor protein tyrosine kinase signaling pathway",
"P:dendrite morphogenesis",
"P:lamellipodium morphogenesis",
"P:megakaryocyte development",
"P:negative regulation of cell population proliferation",
"P:neuron migration",
"P:positive regulation of protein tyrosine kinase activity",
"P:somitogenesis"
] |
[
"GOBP_ACTIN_FILAMENT_BASED_PROCESS",
"GOBP_ACTIN_FILAMENT_ORGANIZATION",
"GOBP_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION",
"GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS",
"GOBP_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION",
"GOBP_CELL_MORPHOGENESIS",
"GOBP_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION",
"GOBP_CELL_MOTILITY",
"GOBP_CELL_PROJECTION_MORPHOGENESIS",
"GOBP_CELL_PROJECTION_ORGANIZATION",
"GOBP_CELL_SURFACE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY",
"GOBP_CYTOSKELETON_ORGANIZATION",
"GOBP_DENDRITE_DEVELOPMENT",
"GOBP_DENDRITE_MORPHOGENESIS",
"GOBP_EMBRYO_DEVELOPMENT",
"GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING",
"GOBP_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY",
"GOBP_EPITHELIUM_DEVELOPMENT",
"GOBP_GENERATION_OF_NEURONS",
"GOBP_HEMOPOIESIS",
"GOBP_LAMELLIPODIUM_MORPHOGENESIS",
"GOBP_LAMELLIPODIUM_ORGANIZATION",
"GOBP_MEGAKARYOCYTE_DEVELOPMENT",
"GOBP_MEGAKARYOCYTE_DIFFERENTIATION",
"GOBP_MYELOID_CELL_DEVELOPMENT",
"GOBP_MYELOID_CELL_DIFFERENTIATION",
"GOBP_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION",
"GOBP_NEUROGENESIS",
"GOBP_NEURON_DEVELOPMENT",
"GOBP_NEURON_MIGRATION",
"GOBP_PATTERN_SPECIFICATION_PROCESS",
"GOBP_PEPTIDYL_AMINO_ACID_MODIFICATION",
"GOBP_PEPTIDYL_TYROSINE_MODIFICATION",
"GOBP_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_PHOSPHORYLATION",
"GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY",
"GOBP_POSITIVE_REGULATION_OF_KINASE_ACTIVITY",
"GOBP_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION",
"GOBP_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION",
"GOBP_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_PHOSPHORYLATION",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS",
"GOBP_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY",
"GOBP_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY",
"GOBP_REGULATION_OF_CATALYTIC_ACTIVITY",
"GOBP_REGULATION_OF_CELL_POPULATION_PROLIFERATION",
"GOBP_REGULATION_OF_KINASE_ACTIVITY",
"GOBP_REGULATION_OF_MOLECULAR_FUNCTION",
"GOBP_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION",
"GOBP_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_PHOSPHORYLATION",
"GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS",
"GOBP_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS",
"GOBP_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY",
"GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY",
"GOBP_SEGMENTATION",
"GOBP_SOMITE_DEVELOPMENT",
"GOBP_SOMITOGENESIS",
"GOBP_SUPRAMOLECULAR_FIBER_ORGANIZATION",
"GOCC_ACTIN_BASED_CELL_PROJECTION",
"GOCC_AXON",
"GOCC_CELL_LEADING_EDGE",
"GOCC_DISTAL_AXON",
"GOCC_FILOPODIUM",
"GOCC_FILOPODIUM_TIP",
"GOCC_LAMELLIPODIUM",
"GOCC_NEURON_PROJECTION",
"GOCC_NEURON_TO_NEURON_SYNAPSE",
"GOCC_POSTSYNAPSE",
"GOCC_POSTSYNAPTIC_SPECIALIZATION",
"GOCC_SCAR_COMPLEX",
"GOCC_SITE_OF_POLARIZED_GROWTH",
"GOCC_SYNAPSE",
"GOMF_CADHERIN_BINDING",
"GOMF_CELL_ADHESION_MOLECULE_BINDING",
"GOMF_CYTOSKELETAL_PROTEIN_BINDING",
"GOMF_ENZYME_ACTIVATOR_ACTIVITY",
"GOMF_ENZYME_REGULATOR_ACTIVITY",
"GOMF_KINASE_ACTIVATOR_ACTIVITY",
"GOMF_KINASE_ACTIVITY",
"GOMF_KINASE_REGULATOR_ACTIVITY",
"GOMF_MOLECULAR_ADAPTOR_ACTIVITY",
"GOMF_MOLECULAR_FUNCTION_ACTIVATOR_ACTIVITY",
"GOMF_PROTEIN_DOMAIN_SPECIFIC_BINDING",
"GOMF_PROTEIN_KINASE_ACTIVITY",
"GOMF_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY",
"GOMF_PROTEIN_TYROSINE_KINASE_ACTIVITY",
"GOMF_SH3_DOMAIN_BINDING",
"GOMF_SIGNALING_ADAPTOR_ACTIVITY",
"GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS",
"HALLMARK_ALLOGRAFT_REJECTION",
"HALLMARK_INFLAMMATORY_RESPONSE",
"HALLMARK_MITOTIC_SPINDLE",
"KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_ESPT_TO_RAC_SIGNALING_PATHWAY",
"KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY",
"KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_TO_RAC_SIGNALING_PATHWAY",
"KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGD_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY",
"KEGG_MEDICUS_REFERENCE_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY",
"PID_ECADHERIN_NASCENT_AJ_PATHWAY",
"PID_ECADHERIN_STABILIZATION_PATHWAY",
"PID_ERBB1_DOWNSTREAM_PATHWAY",
"PID_INTEGRIN_A4B1_PATHWAY",
"PID_PDGFRB_PATHWAY",
"PID_RAC1_PATHWAY",
"PID_RAC1_REG_PATHWAY",
"REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS",
"REACTOME_INFECTIOUS_DISEASE",
"REACTOME_INNATE_IMMUNE_SYSTEM",
"REACTOME_LEISHMANIA_INFECTION",
"REACTOME_PARASITE_INFECTION",
"REACTOME_RAC1_GTPASE_CYCLE",
"REACTOME_RAC2_GTPASE_CYCLE",
"REACTOME_RAC3_GTPASE_CYCLE",
"REACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES",
"REACTOME_RHO_GTPASE_CYCLE",
"REACTOME_RHO_GTPASE_EFFECTORS",
"REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES",
"REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3",
"REACTOME_SIGNALING_BY_VEGF",
"WP_EGFEGFR_SIGNALING"
] |
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