id stringlengths 36 36 | case_id int64 128 13.6k | language stringclasses 2
values | system_prompt stringclasses 1
value | question stringlengths 105 16k | tags dict | rubrics listlengths 11 37 |
|---|---|---|---|---|---|---|
af865a52-51d3-4d3e-b170-d8d249e57f95 | 8,156 | global | You are an orthodontist seeing a 14-year-old male whose chief complaint is protrusive anterior teeth, progressively worsening over the past five years.
Family history: both parents have essentially normal facial profiles, while the grandmother exhibits a similar convex facial pattern. The family acknowledges that this ... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Dentistry"
]
} | [
{
"rubric_detail": "Diagnose skeletal Class II based on SNA and SNB (i.e., an elevated ANB indicating a skeletal Class II relationship).",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 6
},
{
"rubric_detail": "Based on SN–MP = 42°, conclude a high-angle pattern an... | |
68922ab6-13c7-422c-9e0c-2429a4fafd7b | 8,473 | global | The patient was diagnosed with chronic Hepatitis B during a physical examination 20 years ago but did not receive standardized treatment. About one year ago, without obvious precipitating factors, the patient experienced upper abdominal pain. The patient visited a local hospital where 'primary liver cancer' was suspect... | {
"time_sensitivity": {
"day": "17",
"time_sensitivity": "Strongly time-sensitive",
"year_month": "2022-06"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Hepatobiliary and Pancreatic Surgery"
]
} | [
{
"rubric_detail": "Suggests performing a whole-body PET-CT or a contrast-enhanced CT covering the chest, whole abdomen, and pelvis to complete a comprehensive restaging evaluation.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 5
},
{
"rubric_detail": "Lists Chi... | |
82664b2b-6471-4f66-a496-e35a67a18d40 | 8,610 | global | Case information:
A 42-year-old woman was brought to the emergency department for “nausea and vomiting with confusion for 2 hours.” Her family reports a history of “depression,” long-term use of multiple medications (details unknown), and suicidal ideation 6 months ago.
On arrival: T 38.5°C, P 115/min, R 28/min, BP 11... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Emergency and Critical Care Medicine"
]
} | [
{
"rubric_detail": "For seizures and acidosis, the first-line pharmacologic intervention is intravenous bolus administration of high-concentration sodium bicarbonate (NaHCO3).",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 10
},
{
"rubric_detail": "The therapeuti... | |
f003d40a-1190-409d-841e-84da045d24cc | 8,660 | global | Patient: Male, 58 years old. Admitted due to "right upper quadrant abdominal distension and pain accompanied by weight loss and yellowing of the skin and sclera for 2 months." History of chronic hepatitis B for 20 years without regular antiviral treatment; history of long-term alcohol consumption. Physical Examination:... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Hepatobiliary and Pancreatic Surgery"
]
} | [
{
"rubric_detail": "The diagnosis section indicates that a diagnosis of pure hepatocellular carcinoma (HCC) is incomplete or contradictory, and the possibility of combined hepatocellular-cholangiocarcinoma (cHCC-CCA) or synchronous double primary malignancies must be considered.",
"rubric_number": 1,
"r... | |
a4119dbd-d5aa-4b1f-a215-d2f1b7285165 | 8,684 | global | Patient Li XX, female, 67 years old, was admitted due to chest pain persisting for 6 hours. Post-admission electrocardiogram (ECG) indicated ST-segment elevation in leads II, III, and aVF. Emergency cardiac biomarker panel revealed: LDH 205 U/L, CK 288 U/L, CK-MB 57 U/L, and cardiac troponin I (cTnI): 5.04 ng/mL. The p... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Cardiovascular Medicine"
]
} | [
{
"rubric_detail": "The model did not explicitly recommend a pharmacological loading dose comprising chewing 300 mg of Aspirin Enteric-coated Tablets combined with oral administration of 600 mg of Clopidogrel Bisulfate Tablets.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weigh... | |
bb0a8654-2760-4fa0-9fa6-0e047c0d8d71 | 8,710 | global | A 28-year-old woman was admitted to the emergency department due to "severe colicky abdominal pain involving the entire abdomen accompanied by vomiting and limb weakness for 12 hours." She had experienced two similar episodes in the past, both triggered by "dieting for weight loss" or the "premenstrual period." An expl... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Neurology"
]
} | [
{
"rubric_detail": "Barbiturates (e.g., thiopental sodium) are explicitly listed as absolute contraindications for anesthetic induction.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 10
},
{
"rubric_detail": "Omission of: \"Etomidate, by inhibiting 11β-hydroxyla... | |
669ccd28-509f-4e5b-a3c6-f4cc7d8930cf | 9,022 | global | A 56-year-old male patient was admitted to the ICU via the Emergency Department due to 'sudden onset of confusion accompanied by hematemesis for 2 hours.' The patient has a 15-year history of chronic hepatitis B without regular antiviral therapy; liver cirrhosis (compensated stage) was diagnosed 5 years ago; he has a s... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Hepatobiliary and Pancreatic Surgery"
]
} | [
{
"rubric_detail": "Explicitly states that the patient does not present any indications for active anti-tumor treatment (including systemic therapy)",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 10
},
{
"rubric_detail": "The response fails to mention evaluation ... | |
f223b123-621c-466f-b9fc-8e0cbe2785bd | 9,061 | global | You are an orthodontist. You have received a 10-year-old female patient whose parents' chief complaint is dental misalignment and "protrusive maxillary incisors" (buck teeth), which have gradually worsened over the past 2 years. There is no family history of similar facial features.
Upon taking the medical history, it ... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Dentistry"
]
} | [
{
"rubric_detail": "Diagnose Angle Class II malocclusion based on the distal molar relationship.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 5
},
{
"rubric_detail": "Diagnose skeletal Class II malocclusion based on SNA, SNB, and ANB values.",
"rubric_numbe... | |
d9a3a37b-2fde-46f3-90c6-48a6d2215322 | 9,126 | global | Topic: An Anomalous Case of "Fulminant Myocarditis"
Role Setting: You are a Clinical Instructor in the Cardiac Care Unit (CCU).
Case Background: The patient, a 29-year-old female, was admitted to the emergency department due to "fever and generalized myalgia for 3 days, followed by shortness of breath and chest tightne... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Emergency and Critical Care Medicine"
]
} | [
{
"rubric_detail": "Explicitly state that the most likely diagnosis is \"Immune-Mediated Necrotizing Myopathy (IMNM).\"\n",
"rubric_number": 1,
"rubric_tag": "Instructions Following",
"rubric_weight": 10
},
{
"rubric_detail": "Explicitly state that confirmation requires testing for \"Anti-SR... | |
2b54a7d1-2d11-45ff-985e-5ce390ec0e1c | 9,238 | global | An 81-year-old female patient presented with a gastric mass. A submucosal tumor of approximately 15mm in the antrum of the stomach was found on a routine physical examination. She was asymptomatic at that time and was followed up. One year later, a follow-up gastroscopy revealed that the tumor had grown to 20mm, with a... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Gastrointestinal Surgery"
]
} | [
{
"rubric_detail": "List the differential diagnoses that should include GIST (gastrointestinal stromal tumor) and PF (plexiform fibromyxoma).",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 10
},
{
"rubric_detail": "Clearly states that the gold standard for diagn... | |
9fe8853f-42c5-41d4-8622-79e5b6a9a753 | 9,257 | global | Female patient, 60 years old, admitted on February 19, 2016, due to "recurrent upper abdominal distension and pain for over 2 years, aggravated for over 1 month." Over the past 2 years, the patient developed upper abdominal distension and pain without obvious triggers, which became more pronounced after eating or walki... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Gastrointestinal Surgery"
]
} | [
{
"rubric_detail": "The diagnostic conclusion fails to explicitly identify the patient as suffering from juxtarenal abdominal aortic occlusion.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": -10
},
{
"rubric_detail": "Explicitly provides a diagnosis of chronic me... | |
ec20a6b0-7320-454e-8398-8f382a89efd2 | 9,287 | global | Ms. Li, 32 years old, presented with amenorrhea for 9 weeks, with no embryonic cardiac activity detected on ultrasound. A review of her medical history reveals 3 spontaneous abortions within the last 3 years: the 1st was a biochemical pregnancy at 6 weeks, the 2nd involved an empty gestational sac at 9 weeks, and the c... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Obstetrics and Gynecology"
]
} | [
{
"rubric_detail": "Explicitly determine that Ms. Li's condition meets the diagnostic criteria for Recurrent Spontaneous Abortion (RSA).",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 8
},
{
"rubric_detail": "The model fails to correctly define Recurrent Spontane... | |
d19a66bd-6552-4d0f-9574-6128f4f7ff05 | 9,309 | global | I am using HEK-293T cell samples to perform Western Blot (WB) detection of the target protein Nrf2 (approximately 100 kDa). Across multiple experiments, I have frequently observed an absence of signal or extremely weak signal, whereas the internal control protein β-actin (approximately 42 kDa) on the same gel shows cle... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Basic Medicine",
"Molecular Biology"
]
} | [
{
"rubric_detail": "The model iteratively repeats the experimental parameters provided in the user input, resulting in content redundancy.",
"rubric_number": 1,
"rubric_tag": "Structure and Formatting",
"rubric_weight": -5
},
{
"rubric_detail": "The layout is disorganized, lacking clear subh... | |
c437a033-7f62-473c-810d-35ed79d60df6 | 9,462 | global | A 52-year-old female patient was admitted due to "fever and joint pain accompanied by rash for 2 weeks, exacerbated for 3 days." Two weeks prior, the patient developed a fever without an obvious precipitating factor, with body temperature fluctuating between 38.5-39.8°C, accompanied by symmetric swelling and pain in th... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Medical Laboratory Science"
]
} | [
{
"rubric_detail": "Explicitly identifies the patient's most likely preliminary diagnosis as Systemic Lupus Erythematosus (SLE).",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 10
},
{
"rubric_detail": "Diagnostic basis mentions specific mucocutaneous symptoms suc... | |
308de99f-a853-45a6-be11-67be5b113333 | 9,582 | global | Patient: Male, 46 years old. Admitted to the ICU via the emergency department due to "fever, progressive dyspnea accompanied by dry cough for 2 weeks, exacerbated for 2 days." The patient underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloid leukemia (AML) 18 months ago. Admission p... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Respiratory Medicine"
]
} | [
{
"rubric_detail": "Explicitly identifies the patient's core diagnosis as Bronchiolitis Obliterans Syndrome (BOS), a manifestation of chronic Graft-versus-Host Disease (cGVHD) after allo-HSCT",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 8
},
{
"rubric_detail": ... | |
7bcf6aef-2235-45cd-8b02-02e8d9a00a39 | 9,769 | global | I harvested a mouse spleen and mechanically dissociated it to generate a single-cell suspension. I want to use flow cytometry to stain and assess activation of regulatory T cells (Tregs). My current staining panel is: CD3, CD8, Foxp3, and CD44. By flow cytometry, the proportion of Tregs is 0.05%.
Please help me analyz... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Basic Biomedical Sciences",
"Immunology"
]
} | [
{
"rubric_detail": "Identifies improper gating strategy as a possible cause of an abnormally low Treg frequency in flow-cytometry results.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 5
},
{
"rubric_detail": "Argues that Foxp3 antibody inactivation or fluoroph... | |
85a7c05e-2235-4d0c-ba8c-a2cca33ab401 | 9,854 | global | Chief complaint: Elevated blood glucose for over 20 years; poor appetite for 4 days.
History of present illness: More than 20 years ago, a routine health check revealed fasting plasma glucose (FPG) of 10 mmol/L. The patient had no polydipsia, polyphagia, polyuria, or weight loss. He visited our outpatient clinic and w... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Endocrinology and Metabolic Diseases"
]
} | [
{
"rubric_detail": "The diagnostic conclusion explicitly includes type 2 diabetes mellitus and diabetic ketoacidosis (DKA).",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 10
},
{
"rubric_detail": "The diagnostic conclusion includes diabetic peripheral neuropathy.... | |
4e906852-19f1-4380-9fc8-7f39af4ad3ca | 9,890 | global | Patient Profile
Patient: 45-year-old male. BMI 16.5 kg/m² (severe malnutrition), altered mental status (GCS 13), blood pressure 85/50 mmHg (on dopamine infusion).
Core Diagnosis:
Severe Pulmonary Tuberculosis (Type III, critical): Extensive bilateral cavitary destruction, complicated by septic shock.
Severe Acute Resp... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Respiratory Medicine"
]
} | [
{
"rubric_detail": "Did not suggest the immediate discontinuation of the three first-line anti-tuberculosis drugs: Isoniazid, Rifampicin, and Pyrazinamide.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": -8
},
{
"rubric_detail": "Pointed out that the reason for d... | |
31fe657a-50a8-46c8-8186-f6b8da611584 | 9,921 | global | The patient is a 59-year-old male diagnosed with right lung neuroendocrine carcinoma with brain metastases for over one year. His history includes first-line treatment with the "Adebrelimab + EP regimen," followed by maintenance therapy with "Adebrelimab + Etoposide." During maintenance therapy, he underwent radiothera... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Oncology"
]
} | [
{
"rubric_detail": "The preliminary diagnosis explicitly indicates Grade IV myelosuppression, specifically including suppression of leukocytes, neutrophils, and platelets.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 10
},
{
"rubric_detail": "Preliminarily iden... | |
5cc4e65d-8984-4352-8dc4-f707c9da5eb1 | 9,952 | global | Patient Profile: 51-year-old female, premenopausal, no family history of malignancy. ECOG Performance Status 0.
Core Diagnosis: Left triple-negative breast cancer (TNBC) (cT3N1M0, Stage IIIA). Core needle biopsy pathology: Invasive carcinoma of no special type (NST). Immunohistochemistry: ER (-), PR (-), HER2 (0). Ki-6... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Healthcare and Medicine",
"Clinical Medicine",
"Oncology"
]
} | [
{
"rubric_detail": "Explicitly state that since the patient achieved pCR, no additional postoperative adjuvant chemotherapy is required.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 8
},
{
"rubric_detail": "Recommend continuing pembrolizumab for postoperative a... | |
9a22b80c-9d00-488b-9e1e-7f9579efe2c2 | 10,086 | cn | 患者，68 岁，女性，因“多关节疼痛进行性加重、乏力伴食欲下降 3 个月，体检发现肾功能异常”由外院转入。患者近 1 年双膝疼痛明显加重，行走距离显著缩短，夜间疼痛影响睡眠，自述晨起关节僵硬明显，双手小关节反复肿胀、疼痛。骨科门诊影像学评估提示双膝关节结构性破坏明显，认为符合手术指征，拟在进一步完善评估后于 6–8 周内择期行全膝关节置换术（TKA）。术前常规检查发现肾功能异常并合并贫血，骨科建议住院进一步评估，由肾内科牵头开展多学科联合决策。沟通过程中患者多次强调“目前最影响生活的是无法行走，只要能把手术做了，其他问题可以暂时放一放”，对肾功能长期预后及透析相关风险理解有限，家属亦更关注近期疼痛缓解与功能恢复情况。
既往史方面，... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"肾内科"
]
} | [
{
"rubric_detail": "模型应在全文中始终坚持“慢性肾脏病基础上的急性肾损伤（AKI on CKD）”作为唯一诊断框架进行论证，诊断锚点前后一致，所有风险判断与干预取舍均围绕该框架展开，论据与结论逻辑自洽，未混杂其他诊断框架的核心判断或并行叙事。",
"rubric_number": 1,
"rubric_tag": "指令遵循",
"rubric_weight": 8
},
{
"rubric_detail": "需明确指出，仅凭 Scr 多时间点稳定不足以支持“单纯 CKD 自然进展”。",
"rubric_number": 2,
"rubr... | |
e71191ec-40f7-4156-b68d-b70754672fc4 | 10,144 | cn | 患者李某，男，37岁， 1 h前因车祸致伤头部，具体受伤经过不详，患者伤后意识不清，频繁呕吐，由家属陪同120送至我院急诊。
家属诉既往胃溃疡病史，长期口服奥美拉唑治疗。否认高血压、糖尿病、心脏病病史。否认输血史，否认食物药物过敏史，否认肝炎结核等传染病史；按时预防接种。
体格检查：体温36.5℃，心率71次/分，呼吸频率15次/分，血压112/61 mmHg，指脉氧：99%。发育正常，营养良好，昏迷，呼之不应，急性面容，平车推入病房。全身及局部淋巴结无肿大，颈部强直，颈动脉搏动正常，气管居中。呼吸音正常，双肺未闻及干湿性啰音。心率73次/分，心律齐，未闻及心脏杂音。腹部外形正常，腹壁柔软，腹部无压痛，腹部无反跳痛。四肢外观正常。
... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"神经外科"
]
} | [
{
"rubric_detail": "诊断明确列出关键诊断:重型颅脑损伤",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "诊断内容完整涵盖急性硬膜下血肿（ASDH）、硬膜外血肿（EDH）及创伤性蛛网膜下腔出血（tSAH）",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 8
},
{
"rubric_detail": "诊断中需要包含：胃溃疡... | |
b6502878-bfac-4be7-9851-d7364dd2ed3c | 10,185 | cn | 现病史与体格检查：患者，男，58岁，因“咯血伴呼吸困难2天，尿量减少12小时”由急诊科收住入ICU。患者2周前曾有“感冒”病史，随后出现乏力、肌肉酸痛及间断发热。体检：体温 38.2℃，脉搏 112次/分，呼吸 28次/分，血压 145/95mmHg。神志清，消瘦貌，双肺底可闻及湿啰音。双下肢轻度凹陷性水肿。急诊胸部CT示：双肺弥漫性磨玻璃影及斑片状浸润影，以中下肺野为主。辅助检查：血常规：WBC 12.8×109/L，Hb 85g/L。尿常规：尿蛋白(++)，红细胞满视野/HP，可见红细胞管型。生化：血肌酐（SCr）由3天前的 110μmol/L 急剧升至 420μmol/L。免疫学指标：p-ANCA（MPO抗体）强阳性，c-AN... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"肾内科"
]
} | [
{
"rubric_detail": "回复中应包含甲泼尼龙静脉冲击治疗（如500-1000mg/d），并给出后续口服糖皮质激素的具体减量计划（如提及PEXIVAS减量方案或具体的起始剂量）",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 7
},
{
"rubric_detail": "明确指出第2周需要快速减量，并提及第15天（或2周结束时）剂量应减至 30 mg/d",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_wei... | |
c91c56f9-e432-484a-aaeb-867c7143d4bd | 2,860 | cn | CAR-T细胞疗法中，CAR-T细胞的体外制备一直是一个难题。目前的主流制备方法是使用慢病毒感染法，即通过工程化慢病毒感染目标T细胞，将其在体外改造为表达CAR结构的CAR-T细胞。某学生在通过慢病毒感染T细胞的实验中，在通过CD3/CD28磁珠和IL-2细胞因子激活T细胞后，使用1×10e8 TU/ml滴度的慢病毒，以MOI为10的条件下感染T细胞，发现T细胞的感染效率极低，CAR表达阳性的T细胞比例低于10%。请帮助该学生提升T细胞感染效率，从T细胞状态、感染条件和慢病毒质量这三个方面进行论述。 | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"制药与生物技术",
"基因与细胞治疗 (CGT)"
]
} | [
{
"rubric_detail": "明确给出病毒滴度的定义，详细说明病毒滴度至少分为感染滴度和物理滴度两种，",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 10
},
{
"rubric_detail": "必须说明通过T细胞与慢病毒共孵育开始时，使用800~1200xg的条件，32摄氏度离心30~90min可以显著提高慢病毒的感染效率",
"rubric_number": 2,
"rubric_tag": "观点分析",
"rubric_weight": 8
},
... | |
908f40e1-2d85-4e57-9320-cfc6fc450037 | 3,596 | cn | 病例：
患者，女，72 岁。主诉：“腹痛、发热伴呕吐 5 天，加重 1 天”。5 天前出现右下腹持续性疼痛，伴恶心、呕吐、食欲差，2 天前出现发热（最高 38.9℃），自行口服抗生素无效。近 24 小时腹痛明显加重，出现腹胀、肛门停止排气排便。既往史：2 型糖尿病 20 年，胰岛素治疗，HbA1c 8.9%。类风湿关节炎 18 年，长期口服甲氨蝶呤 12.5 mg/周 + 泼尼松 7.5 mg/d。冠心病，3 年前置入支架，长期服用阿司匹林。慢性肾功能不全（CKD 3a 期）。查体：
T 38.5℃，HR 112 次/分，BP 96/58 mmHg。腹部膨隆，右下腹压痛明显，反跳痛（+），肌紧张（+），肠鸣音减弱。
实验室检查：WB... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"胃肠外科"
]
} | [
{
"rubric_detail": "明确否定暂缓手术的空间，指出抗生素无法修补穿孔或逆转坏死，且脓肿难以渗透",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 7
},
{
"rubric_detail": "指出增强CT中回盲部肠壁分层结构消失提示肠壁血供受损，存在缺血或坏死的高度可能",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 6
},
{
"rubric_detail": "指出游... | |
578de37e-4cff-4436-8c44-d2cdc176d598 | 4,623 | cn | ChIP‑qPCR 富集信号弱、重复性差
在做转录因子 ChIP‑qPCR 时：
阳性靶点位点在第一次实验中富集约 5–8 fold（相对 IgG 对照），第二次仅 1.5–2 fold；
阴性对照位点富集始终接近 1；
Input DNA 质量和浓度在两次实验中相近，qPCR 标准曲线表现良好。
问题：请提出 4–5 个最可能与“免疫沉淀步骤”本身相关的原因，并针对每一条设计验证与优化方案（如：交联条件、裂解/剪切、抗体质量与用量、洗涤强度、珠子饱和性等），要求明确：如何通过对照设置和 readout 指标判断某一环节是主要问题来源。 | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"基础医学",
"病理生理学"
]
} | [
{
"rubric_detail": "模型提出了 4-5 个与免疫沉淀步骤相关的具体原因（交联条件不当、染色质片段化程度、抗体效价/批次差异、洗涤缓冲液严谨度、磁珠结合载量、非特异性结合等）。",
"rubric_number": 1,
"rubric_tag": "指令遵循",
"rubric_weight": 7
},
{
"rubric_detail": "模型针对每一个提出的原因，都包含了具体的验证方案（如通过设置不同条件的对照组进行验证）和优化策略（如调整实验参数、更换试剂等）。例如，针对抗体问题，验证方案可包括抗体滴定，优化方案可包括更换为ChIP级别认证的抗体。... | |
7b7fe40e-e5d7-4cc0-887b-3c1d216bee06 | 4,803 | cn | 患者男性，52岁，因“右上腹隐痛2月，加重1周”入院。既往有乙肝病史20余年，未规范抗病毒治疗。有长期饮酒史。入院查体：慢性肝病面容，皮肤巩膜轻度黄染，腹部膨隆，移动性浊音阳性。辅助检查：肝功能Child-Pugh B级（8分），CT示：肝右叶巨块型肝癌（最大径10cm），门静脉右支癌栓形成，左肝外叶见2个卫星灶（直径约1.5cm、2.0cm），少量腹水。甲胎蛋白（AFP）>1200 ng/mL。ECOG评分1分。请结合该病例，回答以下问题：1.该患者目前最主要的治疗矛盾是什么，阐述治疗决策的核心思路与优先顺序。2.请为患者设计一个初步的、具有逻辑顺序的综合治疗方案，并详细说明每一步选择的具体理由和预期目标。3.假设患者在初步治疗后... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"肝胆胰外科"
]
} | [
{
"rubric_detail": "准确识别核心矛盾：明确指出“高肿瘤负荷（巨块原发灶+门静脉癌栓+卫星灶）与有限且不稳定的肝功能储备（Child-Pugh B级伴腹水）之间的尖锐冲突”是限制所有治疗决策的根本矛盾。",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "确立正确的治疗优先级：清晰阐述“保肝支持（控制腹水、改善一般情况）→病因治疗（立即启动强效抗病毒）→抗肿瘤治疗”的不可动摇的先后顺序。",
"rubric_number": 2,
... | |
cd123b23-75a5-4619-8b9e-c77c7f5d9672 | 5,217 | cn | Western Blot 目标条带缺失但出现强烈非特异条带
在检测某膜受体蛋白（预期分子量约 140 kDa）时：
使用商业单克隆抗体 A，在 3 个不同细胞系中：
细胞系 1（高表达阳性对照）：在 ~140 kDa 处有清晰条带，并有一个 ~70 kDa 的额外强条带；
细胞系 2（中等表达）：140 kDa 条带较弱，但 70 kDa 条带非常强；
细胞系 3（CRISPR 敲除该基因的克隆）：140 kDa 条带完全消失，但 70 kDa 条带仍然强烈存在；
更换另一家公司的多克隆抗体 B，同样条件下：
140 kDa 条带在细胞系 1、2 中均可见，在 KO 细胞中消失；
70 kDa 条带明显减弱或消失。
问题：请列出 ... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"基础医学",
"病理生理学"
]
} | [
{
"rubric_detail": "回答指出可能原因之一是单克隆抗体A存在非特异性交叉反应（Off-target），识别了无关的70 kDa蛋白",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 7
},
{
"rubric_detail": "回答基于KO细胞中140 kDa消失但70 kDa保留的现象，逻辑推导得出70 kDa条带极有可能源自非目标基因产物",
"rubric_number": 2,
"rubric_tag": "观点分析",
"rubric_weight":... | |
c6b234bb-2142-4b26-993d-a0c2984a3943 | 5,259 | cn | 病例信息：
患者，男，65岁，主诉“吞咽困难伴胸痛3个月，近1个月进食哽咽感明显，不能进固体食物”入院。患者有吸烟史40年（每日20支），饮酒史30年，既往有慢性支气管炎病史，否认高血压、糖尿病及心脏病史。3个月前无明显诱因出现吞咽困难，初为固体食物，后逐渐发展至半流质，伴进食后胸骨后疼痛，体重下降8kg。入院查体：消瘦，浅表淋巴结未触及肿大，双肺呼吸音粗，未闻及干湿啰音，心腹查体无异常。辅助检查：血常规正常，肿瘤标志物CEA 8.2ng/ml、CYFRA21-1 12.5ng/ml升高；上消化道造影示食管中下段长约8cm不规则狭窄，黏膜破坏中断；胸部增强CT示食管中下段管壁不规则增厚（最大厚度18mm），管腔明显狭窄，纵隔多发淋巴... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"心血管外科/胸外科"
]
} | [
{
"rubric_detail": "回答指出患者因合并中度COPD且处于III期，直接手术风险高且非最优策略，应先行新辅助治疗",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 7
},
{
"rubric_detail": "明确指出当肺功能下降至FEV1<50%时，治疗策略转变为根治性放化疗",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 7
},
{
"rubric_detail": ... | |
4bb63011-2170-4483-b171-2c74d2bf6102 | 5,555 | cn | 病例信息：
患者，女性，45岁，主诉“发现颈前肿块2个月，伴声音嘶哑1个月”。2个月前无意中触及颈前无痛性肿块，逐渐增大，近1个月出现声音嘶哑，无吞咽困难、呼吸困难，无怕热多汗、心悸等症状。既往体健，无放射线暴露史，家族中无甲状腺癌病史。查体：颈前右侧可触及一约4cm×3cm肿块，质硬、表面不光滑、边界不清，随吞咽活动差，左侧甲状腺未触及异常；无颈部淋巴结肿大。间接喉镜检查：右侧声带固定于正中位。甲状腺功能正常，Tg 85 ng/ml（正常<55），TgAb、TPOAb阴性。颈部超声：右侧甲状腺叶内4.2cm低回声结节，形态不规则、边界不清、纵横比>1，内见粗大钙化及丰富血流信号，TI-RADS 5类；左侧甲状腺正常；未见明显肿大淋... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"甲乳外科"
]
} | [
{
"rubric_detail": "明确将本例患者肿瘤分期判定为T4a期",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 10
},
{
"rubric_detail": "阐述了进行全甲状腺切除的理由之一是为术后放射性碘（RAI）治疗做准备及便于Tg监测",
"rubric_number": 2,
"rubric_tag": "观点分析",
"rubric_weight": 7
},
{
"rubric_detail": "模型错误地建议使用‘剃刀技术’保留神... | |
06be9028-f633-4737-98f3-b523421b1276 | 5,766 | cn | 在进行人类肝细胞癌样本石蜡切片的免疫组织化学染谷氨酰胺合成酶（GS）时，我发现仅有部分切片上染出了正常的GS阳性信号，而GS作为HCC的标志性marker之一，一般而言在HCC中广泛表达。已知所有样本的IHC染色均是同一批次、同一组内完成的，请你帮忙分析其中可能的原因。 | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"基础医学",
"病理学"
]
} | [
{
"rubric_detail": "指出肿瘤异质性是导致部分切片未染出GS阳性信号的生物学原因，（包括分化程度差异和分子分型差异）",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 5
},
{
"rubric_detail": "提及GS在肝细胞癌中通常呈弥漫性表达，但并非所有病例均有表达，低分化亚型和非β-catenin激活型的肝细胞癌可能存在GS表达减弱或缺失的情况",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_we... | |
81e7a86e-6dfc-4a5b-8fdc-281924e24a45 | 6,111 | cn | 70岁女性，近2月阴道出现异常分泌物，伴异味，无阴道出血，伴下腹不适。患者就诊于当地某医院，行B超提示：宫腔线分离5mm。患者于当地医院住院，入院当天出现咳嗽，行胸部CT示：双下肺肺炎。遂给予莫西沙星静滴3天后，于静脉麻醉下行宫腔镜检查，镜下见：宫腔积脓，冲洗宫腔后行诊刮术。术后1小时患者出现寒战，体温升高至38.6℃，血氧饱和度90%，心率100次/分。请考虑患者发热的原因及需要完善的相关检验检查。 | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"妇产科学"
]
} | [
{
"rubric_detail": "首要诊断识别出患者可能出现脓毒症（Sepsis）或菌血症，甚至处于感染性休克早期",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 5
},
{
"rubric_detail": "指出根据《宫腔积脓诊治中国专家共识2023年版》，宫腔积脓时子宫内膜呈急性炎症改变，诊断性刮宫可能引发菌血症或败血症等全身感染，加重病情，不推荐常规进行。",
"rubric_number": 2,
"rubric_tag": "观点分析",
"rubric_wei... | |
b9616065-9034-471b-8410-d53f231f1b5a | 6,178 | cn | 54岁女性患者，既往有类风湿关节炎病史8年，长期服用甲氨蝶呤15mg/周+羟氯喹200mg bid治疗，1周前出现发热症状，体温高达38.8、有干咳，伴进行性呼吸困难，入院完善胸部CT示双肺磨玻璃影。血常规：白细胞4.2×10⁹/L，淋巴细胞0.8×10⁹/L，CRP 65mg/L；新冠核酸阴性，痰培养结果显示无致病菌生长，自身抗体谱（抗核抗体、抗ENA）较半年前无明显变化。
问题：请明确该患者肺部病变最可能的病因，说明鉴别诊断要点，给出针对性治疗方案及停药/换药的具体依据，同时列出治疗期间需监测的关键指标及预警阈值。 | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"风湿免疫科"
]
} | [
{
"rubric_detail": "回答中明确指出：该患者最可能的诊断为长期服用免疫抑制剂后导致的肺孢子菌肺炎（PJP/PCP）",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 9
},
{
"rubric_detail": "回答中指出：诊断依据中提及该患者实验室检查淋巴细胞减少是发生PJP的独立危险因素",
"rubric_number": 2,
"rubric_tag": "观点分析",
"rubric_weight": 7
},
{
"rubric_de... | |
8ab658c4-f8c5-4533-9025-1dbcc2dad0ae | 6,342 | cn | 在进行临床试验设计时，我们通常需要精心设计采血点。对于司普奇拜单抗这个药物，说明书适应症是特异性皮炎，考虑到司普奇拜单抗是白介素4α受体抑制剂，以及此受体近年来在肿瘤领域被深入研究。我们计划联合司普奇拜和PD1/PDL1抑制剂来进行针对淋巴瘤患者的二期单臂临床试验。请你设计针PK与PD的稀疏采样采血点。最好以表格形式进行呈现。（司普奇拜SC，频率Q3W;PD1/PDL1抑制剂为IV，频率Q3W） | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"制药与生物技术",
"生物药 (大分子)"
]
} | [
{
"rubric_detail": "纳武利尤单抗（ICI）的采样点包含输注结束后15分钟内的输液结束点",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "依据司普奇拜说明书，C1 Day4被设定为最早达峰时间点",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 8
},
{
"rubric_detail": "第一周期的采样点包含了Day4、... | |
1135b8c9-60eb-4cd1-abfa-3d11bd522bb8 | 6,817 | cn | 你是一名主治医师。你需要为一名复杂的骨质疏松症合并肾功能不全的患者指定一个诊疗方案。
患者核心诉求：患者既往长期腰背部疼痛，由于合并肾功能不全，希望控制疾病发展同时避免肾功能受损。
病人关键信息：女性，69岁，主诉“腰背部疼痛5个月，加重伴乏力2周”
现病史：腰背部疼痛5个月，加重伴乏力2周。无发热。患者自发病以来体重、食欲、睡眠无明显变化。
既往史：高血压病史15年，慢性肾功能不全4年。
个人史：否认烟酒史。否认外伤史、手术史。否认药物过敏史。
体格检查：脊柱胸腰段存在压痛，双下肢轻度水肿，四肢肌力正常，未触及明显包块。
辅助检查：肌酐280umol/L，肾小球滤过率eGFR≈25mL/min/1.73m2。甲状旁腺激素（PTH）... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"骨科"
]
} | [
{
"rubric_detail": "应该确定治疗的先后顺序：优先控制肾功能不全合并矿物质与骨异常（CKD-MBD），在CKD-MBD相关指标（如钙、磷、PTH）得到控制后再治疗骨质疏松",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 10
},
{
"rubric_detail": "补钙方案指出需在血磷控制在1.8mmol/L以下后，再开展补钙治疗，服用碳酸钙600mg bid",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubr... | |
1d156a89-d475-4c7a-8f19-ffc4a8514323 | 6,944 | cn | 一个遗传学研究团队收集了一个呈现 “早发性多系统神经发育障碍伴特殊面容” 的散发病例（先证者）。患者父母表型正常，无家族史。初步的染色体微阵列分析（CMA）和常见综合征的靶向基因检测均为阴性。团队决定对先证者及其父母（核心家系）进行家系全外显子组测序（Trio-WES），以期发现致病基因。现Trio-WES已完成，平均测序深度>100X，覆盖度>98%。初步生物信息学流程（比对、变异检出、注释）已得到包含约5-7万个变异位点的初始数据集。请设计一个逐步 “过滤” 变异以缩小候选基因范围的具体流程。并说明每一步的筛选标准和生物学/遗传学依据。 | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"基础医学",
"分子生物学"
]
} | [
{
"rubric_detail": "鉴于先证者散发且父母表型正常的背景，回答需将新发显性（De novo Dominant）列为最高优先级的遗传模式",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 10
},
{
"rubric_detail": "分析中需包含对X连锁隐性遗传模式的考量，指出若先证者为男性，致病变异可能源自母亲携带",
"rubric_number": 2,
"rubric_tag": "观点分析",
"rubric_weight": 10
},
{
... | |
de587f91-b1b2-4ec5-aa58-e48b2c9e5fb9 | 7,240 | cn | 一名55岁男性糖尿病患者，患病10年，血糖控制较差，HbA1c为8.5%。患者未出现明显视力下降，但在定期眼底检查中，发现双眼有微血管改变，左眼视网膜呈现多处微血管瘤和轻度出血斑，右眼则有少量渗出和微血管瘤。患者近期出现夜间视物模糊和低光环境下视力不清。请分析该患者的病情并根据眼底检查结果提供相应的治疗建议。你认为该患者属于哪一临床分期？该如何处理？ | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"眼科"
]
} | [
{
"rubric_detail": "右眼的临床分期被明确判定为中度非增殖性糖尿病视网膜病变（NPDR）",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 8
},
{
"rubric_detail": "左眼的临床分期被明确判定为中度非增殖性糖尿病视网膜病变（NPDR）",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 8
},
{
"rubric_detail": "分期依据中指出了虽然存在... | |
673490a8-a490-4809-8a7c-f2950685c331 | 7,459 | cn | 不同区域（如肿瘤中心、边缘、浸润前沿）的细胞组成、空间排布及其与癌细胞的相互作用，是导致治疗效果不佳和复发的关键因素。空间组学技术（如空间转录组学或空间基因组学）为研究这些问题提供了强有力的工具。
请选择一种你熟悉的空间组学技术（如空间转录组学的 Visium 技术），并结合 HCC 研究的具体场景，回答以下问题，不超过800字：
实验设计与数据分析：为了研究 HCC 的空间异质性，你会如何设计一个具体的实验方案？在数据分析层面，你需要重点关注哪些生物信息学工具或方法来解决空间坐标与基因表达数据的整合问题？
科学问题与应用价值：利用该技术，你期望能回答 HCC 研究中的哪些关键科学问题？该技术在指导 HCC 的精准治疗或预后评估方面... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"基础医学",
"医学遗传学"
]
} | [
{
"rubric_detail": "明确选择了一种具体的空间组学技术（如Visium）作为回答的基础技术手段",
"rubric_number": 1,
"rubric_tag": "指令遵循",
"rubric_weight": 5
},
{
"rubric_detail": "样本处理步骤具体描述了制备冰冻切片（如10μm）及在芯片上进行固定、透化和mRNA捕获的过程",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detai... | |
44847f8f-e10a-493b-a867-e505808f510f | 7,947 | cn | 病例信息：
患者，女，38岁。因“反复多发性骨痛伴肌无力2年余，加重伴体重减轻6个月”就诊。2年来患者无明显诱因出现全身多处骨痛，以腰背部、四肢为主，呈进行性加重，伴肌肉无力、行走困难，近6个月体重减轻约10kg。既往有反复肾结石病史3年，曾多次发作右侧肾绞痛，经体外碎石及对症治疗后缓解。否认颈部放射史及类似疾病家族史。
体格检查：身高较既往缩短约3cm，脊柱后凸畸形，四肢近端肌力Ⅳ级，腰椎、髋关节及双侧膝关节叩痛阳性，无明显红肿。实验室检查：血钙3.25mmol/L（参考值2.10～2.60mmol/L），血磷0.65mmol/L（参考值0.80～1.45mmol/L），碱性磷酸酶820U/L（参考值40～150U/L），血肌酐、... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"甲乳外科"
]
} | [
{
"rubric_detail": "明确指出在拟定手术方案前必须排除的疾病是甲状旁腺癌（PC）",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "列举不支持恶性诊断的证据时，指出长期重度PHPT本身可引起代谢亢进、厌食导致消瘦",
"rubric_number": 2,
"rubric_tag": "观点分析",
"rubric_weight": 10
},
{
"rubric_detail": "针对术中发现粘... | |
653c82d5-3dfa-44f7-b570-ca9ae59aa715 | 8,083 | cn | 患者小李今年50岁，自诉近一年来自觉牙齿隐痛不适、松动，牙龈肿大伴有出血症状，近三日来发热，右侧后牙区疼痛，夜间加重无法入眠，自行服用“甲硝唑”未见缓解，现张口不适，右侧面部有肿胀感。询问既往史，小李有“高血压”十余年，自行服用降压药，血压稳定，否认其他全身系统性疾病。口内检查：口腔卫生不良，下前牙区牙龈充血水肿、增生，牙石Ⅱ°-Ⅲ°，12、11、21、22、31、32、41、42 松动度Ⅱ°，余牙松动度轻微到Ⅰ°；36 伸长，远中邻面颈部及深龋入髓，无探痛，叩痛（+），松动度Ⅰ°，颊侧牙龈探及瘘管溢脓；47 伸长，远中牙体有缺损，探痛（++），叩痛（+），松动度Ⅱ°；48 水平阻生，远中龈瓣覆盖，龈瓣边缘充血水肿，46-48 颊侧... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"口腔医学"
]
} | [
{
"rubric_detail": "主诉诊断明确指出了48冠周炎",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "主诉诊断中包含了咬肌间隙感染的可能性",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 7
},
{
"rubric_detail": "确诊检查建议中包含了血常规化验",
"rubric_number": 3,
... | |
b625b3c1-a92d-4234-911a-dfab5072dd51 | 8,156 | cn | 你是一名正畸医生，接诊了一位14岁的男性患者。主诉前牙前突，近五年来逐渐加重。
家族史：其父母面型基本正常，祖母存在类似凸面型特征。家属虽承认家族中存在相应面型，但因父母面型正常，故认为该问题应该非遗传因素所致。并提及患者乳牙列期间面型正常，替牙期间前突逐渐显现。
家属表示曾通过网络渠道了解到部分类似病例未行拔牙矫治亦取得良好效果，因此明确要求进行不拔牙矫正方案，并对最终美学效果抱有较高期望。
口外检查显示患者上颌前凸、下颌后缩、颏部肌肉紧张；面下1/3长；正面基本对称，可见黑眼圈。患者已经变声，有胡茬。口内检查可见：上牙列及下牙列拥挤度均为2mm。上下前牙唇倾，前牙深覆盖III度，覆合正常。双侧磨牙远中关系。头影测量显示：SNA=... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"口腔医学"
]
} | [
{
"rubric_detail": "根据sna和snb得出骨性II类诊断",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 6
},
{
"rubric_detail": "依据SN-MP=42度，得出高角或垂直生长型",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 6
},
{
"rubric_detail": "建议前往耳鼻喉科排查鼻炎、腺样体或扁桃体肥大等呼吸道问题",
"ru... | |
86b11c02-b600-44ff-9806-176a723cdddf | 8,473 | cn | 患者于20年前体检时确诊为慢性乙型病毒性肝炎，未予规范治疗。1年前余无明显诱因出现上腹部疼痛，就诊于当地医院，怀疑“原发性肝癌”，遂就诊于肿瘤医院，确诊“原发性肝癌”，给予口服“仑伐替尼”10月及TACE治疗8次。现长期口服靶向药物"瑞戈非尼"治疗。我院门诊行上腹部磁共振平扫加增强示:1、肝右叶较大混杂信号多结节病灶治疗后改变,大部病灶未见明显强化，肝顶外侧病灶周围团片状强化,提示该病灶周围肿瘤组织复活。2、胆囊窝处类圆形软组织信号影混杂信号影充填,似见其与胆囊管相连,胆囊结石可能,请结合临床病史及相关检查。3、左肾囊肿。甲胎蛋白测定(AFP)[2022-6-1711:00:33]:甲胎蛋白1920.000ng/mL。请你对该病人给... | {
"time_sensitivity": {
"day": "17",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "2022-06"
},
"topics": [
"医疗健康",
"临床医学",
"肝胆胰外科"
]
} | [
{
"rubric_detail": "建议进行全身PET-CT或涵盖胸部、全腹部、盆腔的增强CT检查以完成全面再分期评估",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 5
},
{
"rubric_detail": "列出了Child-Pugh分级或ICG-15分钟滞留率作为肝功能储备评估的具体指标",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 5
},
{
"rubric_detail... | |
3107f221-d3cc-4401-b0e1-0b2fe36264f4 | 8,610 | cn | 病例信息：
患者，女性，42岁，因“恶心、呕吐伴意识模糊2小时”被送至急诊。家属诉患者既往有“抑郁症”病史，长期服用多种药物（具体不详），半年前曾有自杀倾向。入院查体：T 38.5°C，P 115次/分，R 28次/分，BP 110/70 mmHg。患者表现为躁动不安，面部潮红，双侧瞳孔直径约5mm，对光反射迟钝。皮肤干燥、无汗。肺部听诊（-），腹部平软，肠鸣音极度减弱。四肢肌张力增高，双侧腱反射亢进，Babinski征（-）。
辅助检查：血气分析示 pH 7.32，PaCO2 30 mmHg，PaO2 95 mmHg，HCO3− 16 mmol/L，乳酸 3.2 mmol/L。血常规：WBC 12.5×109/L，N 82%。心电... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"急诊与危重症"
]
} | [
{
"rubric_detail": "针对抽搐和酸中毒，首选药物方案为静脉推注高浓度碳酸氢钠（NaHCO3）",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "碳酸氢钠治疗的目标是将血浆pH值维持在7.45-7.55之间,QRS波时限(＜100 ms)",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 4
},
{
"rubric_detail... | |
eb90ce6e-8a53-4fc4-8b71-4fc2f6913cdc | 8,660 | cn | 患者男性，58岁，因“右上腹胀痛伴消瘦、皮肤巩膜黄染2月”入院。有慢性乙型肝炎病史20年，未规律抗病毒治疗，有长期饮酒史。查体：皮肤巩膜中度黄染，肝肋下3cm可及，质硬，边缘不规则，无压痛。实验室检查：血常规示轻度贫血；肝功能：ALT 120 U/L，AST 185 U/L，TBil 85 μmol/L，DBil 70 μmol/L，ALB 32 g/L；乙肝两对半示HBsAg、HBeAb、HBcAb阳性，HBV-DNA 5.6×10⁴ IU/mL；肿瘤标志物：AFP 1250 ng/mL，CEA 35 ng/mL，CA19-9 480 U/mL。上腹部增强CT显示：肝右叶可见一大小约6.5cm×5.8cm的不规则肿块，动脉期明显不... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"肝胆胰外科"
]
} | [
{
"rubric_detail": "诊断部分指出单纯的肝细胞癌（HCC）诊断不完整或存在矛盾，需考虑混合型肝细胞-胆管癌（cHCC-CCA）或双原发癌的可能性",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "依据中提及AFP显著升高且右叶病灶呈“快进快出”典型表现，支持HCC成分的存在",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 8
},
{... | |
4c394bc9-4f72-4b9d-b5ec-7b26968c8d68 | 8,684 | cn | 患者李xx，女，67岁，因胸痛6小时入院。入院后心电图提示II、III、AVF导联ST段抬高。急诊心肌酶检查提示：LDH 205U/L，CK 288U/L，CKMB 57U/L，肌钙蛋白I（cTnI）：5.04ng/ml。患者既往高血压10年，最高达210/118mmHg，长期口服苯磺酸左氨氯地平片（5mg/日）及缬沙坦（80mg/日），自诉血压控制尚可，入院后测血压138/89mmHg。否认糖尿病史。既往胃溃疡病史，2年前曾发生胃溃疡出血，服用抑酸、保护胃黏膜等药物后治愈。入院后查体：急性面容，神志清。听诊心率98次/分，律齐，未闻及心音分裂，各瓣膜听诊区未闻及病理性杂音。双肺底可闻及少许湿性啰音。现针对该患者，请给出紧急和后续治... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"心血管内科"
]
} | [
{
"rubric_detail": "模型没有明确推荐以阿司匹林肠溶片300mg嚼服联合硫酸氢氯吡格雷片600mg口服进行药物负荷",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": -10
},
{
"rubric_detail": "模型给出的诊断应包括心功能评级，明确为Killip分级（2级）",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 3
},
{
"rubric_detail": ... | |
fe491b1f-b37b-4f37-8e93-509ebcd000e9 | 8,710 | cn | 患者，女性，28岁，因“全腹剧烈绞痛伴呕吐、四肢无力12小时”急诊入院。患者既往有类似发作史两次，均在“减肥节食”或“月经前期”诱发，曾行剖腹探查术未见异常，诊断为“肠功能紊乱”。查体：T 37.4°C，P 118次/分，R 22次/分，BP 165/105 mmHg。神志清楚，表情极其痛苦，呼叫呻吟；双侧瞳孔等大等圆，对光反射存在；腹部平软，全腹轻压痛，但无固定压痛点，无反跳痛及肌紧张，肠鸣音减弱。神经系统检查：四肢肌力3级，腱反射减弱，病理征阴性。
实验室检查：血常规及淀粉酶正常；血钠126 mmol/L，血钾3.4 mmol/L；尿常规示尿蛋白（-），隐血（-），但家属反映患者近两次尿液在放置阳光下观察后，颜色似乎有所加深，呈... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"神经内科"
]
} | [
{
"rubric_detail": "巴比妥类药物（如硫喷妥钠）被明确列为麻醉诱导的绝对禁忌药物",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "遗漏了“依托咪酯因抑制11β-羟化酶干扰皮质醇合成，应被认定为禁忌药物”",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": -20
},
{
"rubric_detail": "未识别出氯胺酮在本例... | |
7cc331b2-297b-4311-ba03-a5ed0a27996b | 9,022 | cn | 患者男性，56岁，因“突发神志模糊伴呕吐鲜血2小时”由急诊科送入ICU。患者既往有慢性乙型肝炎病史15年，未规律抗病毒治疗；5年前发现肝硬化（代偿期）；吸烟史30年。查体：T 37.2℃，P 128次/分，R 26次/分，BP 85/50 mmHg。深昏迷，皮肤巩膜中度黄染，前胸可见数枚蜘蛛痣，腹部膨隆，移动性浊音（+）。实验室检查示：HGB 65g/L，WBC 12.0×109/L，PLT 45×109/L；总胆红素 58μmol/L，白蛋白 26g/L，凝血酶原活动度（PTA） 42%；AFP 850ng/mL。急诊胃镜示食管静脉曲张破裂出血（EVB），已行硬化剂治疗，目前生命体征在快速补液及血管加压素维持下趋于稳定。入ICU后... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"肝胆胰外科"
]
} | [
{
"rubric_detail": "明确指出该患者不具备任何积极抗肿瘤治疗（包括系统治疗）的指征",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "回复中未提及肝移植评估。",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": -8
},
{
"rubric_detail": "依据患者腹水、黄疸、凝血功能及神志状况，判定其肝功能分级为Child... | |
81bf36b9-d2b6-40e6-9f4e-870fa0212b31 | 9,061 | cn | 你是一名口腔正畸医生，接诊了一名10岁的女性患儿，其家长主诉是牙齿不整齐和龅牙，近2年逐渐加重。家族中未见类似面容。
询问病史后得知患儿有夜间口呼吸习惯，于耳鼻喉科就诊发现腺样体肥大，重度阻塞性睡眠呼吸暂停，药物治疗3个月未见明显改善。
口外检查可见侧貌凸，上颌前突，下颌后缩，面下1/3长。口内检查可见：混合牙列，上下前牙中度拥挤不齐，上牙弓狭窄，前牙II度深覆盖，I度深覆合，双侧磨牙远中关系。
头影测量可见C2锥体下缘出现凹陷，C3及C4椎体下缘平坦，SNA=80度，SNB=74度，SN-MP=32度，U1-PP=120°，L1-MP=90°。
经家属在网上了解及其他诊所就诊，提出以下诉求：
1、不可以拔牙矫正，否则以后牙齿会稀疏... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"口腔医学"
]
} | [
{
"rubric_detail": "根据磨牙远中关系，诊断为安氏Ⅱ类错颌畸形",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 5
},
{
"rubric_detail": "依据SNA、SNB及ANB数值，诊断为骨性II类错颌",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 5
},
{
"rubric_detail": "根据颈椎椎体形态，得出发育处于CS2期，正值生长发育高峰期前",... | |
611c260e-93ef-4391-bbdd-0beda5f267de | 9,126 | cn | 题目：不合常理的“爆发性心肌炎”
身份设定： 你是心内科ICU（CCU）的带教老师。
病例背景： 患者，女性，29岁，因“发热、全身肌肉酸痛3天，气促、胸闷6小时”急诊入院。 现病史： 患者3天前无诱因出现低热、乏力及大腿肌肉酸痛。6小时前突发呼吸困难。急诊查心电图示：窦性心动过速（130次/分），广泛ST-T改变。心肌酶谱显著升高：cTnI 15.6ng/ml（参考值<0.03），CK 18,500U/L，CK-MB 420U/L。NT-proBNP 4500pg/ml。超声心动图（UCG）示：左室壁弥漫性运动减弱，LVEF 35%。初步诊断为“急性爆发性心肌炎、心源性休克”。 转折点： 入院后予以ECMO（体外膜肺氧合）支持，... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"急诊与危重症"
]
} | [
{
"rubric_detail": "明确指出最可能诊断为“免疫介导坏死性肌病（IMNM）”。\n",
"rubric_number": 1,
"rubric_tag": "指令遵循",
"rubric_weight": 10
},
{
"rubric_detail": "明确指出确诊需检测“抗SRP抗体”。\t",
"rubric_number": 2,
"rubric_tag": "指令遵循",
"rubric_weight": 8
},
{
"rubric_detail": "提出治疗需使用“IVIG（静脉注射免疫球蛋白）”或“利... | |
dcfde4cd-fcb9-4390-94ea-3b8016158250 | 9,238 | cn | 一位81岁女性患者，既往体检发现胃窦部有一约15mm的黏膜下肿瘤，当时无症状，予以随访。1年后复查胃镜，发现肿瘤增大至20mm，且表面出现中心凹陷，伴有贫血。超声内镜（EUS）显示病变起源于胃壁黏膜肌层，呈均匀低回声，固有肌层完整，大小约14.2 x 8 mm。CT检查未见淋巴结肿大或远处转移。
问题：
1、基于病变进展及影像学特征，你首先考虑的鉴别诊断有哪些？确诊的金标准是什么？
2、针对该病变的大小和形态特征，获取术前病理的最佳活检方式是什么？并说明理由。
3、若活检病理提示“梭形细胞增生，SMA(+)，Desmin(-)，c-KIT(-)，CD34(-)，S100(-)”，确诊为何种肿瘤？
4、考虑到肿瘤位置靠近幽门及性质，... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"胃肠外科"
]
} | [
{
"rubric_detail": "列举出鉴别诊断需包括GIST（胃肠道间质瘤）及PF（丛状纤维黏液瘤）。",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 10
},
{
"rubric_detail": "明确指出确诊的金标准是组织病理学及免疫组化。",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 6
},
{
"rubric_detail": "推荐针对凹陷进行咬取活检",
"... | |
dd646f83-7a44-4e24-8240-f626624fa179 | 9,257 | cn | 患者女，60岁，因"反复上腹部胀痛2年余，加重1个月余"于2016年2月19日入院。患者近2年来无明显诱因出现上腹部胀痛，进食或行走后明显，多次在外院诊治，诊断为"胃炎"，给予对症支持治疗后症状可稍缓解。近1个月来，上述症状加重伴恶心、呕吐，呕吐物为胃内容物，伴反酸、胸部烧灼感，乏力、乏味，无咯血、出血及血便，伴胸闷、心慌、头昏、头晕，伴腰部及下肢疼痛，可耐受，无发热。既往高血压史10余年，规律服用降压药，血压控制尚可。查体：脉搏79次/min，律齐；血压147/73 mmHg(1 mmHg＝0.133 kPa)；双下肢无水肿，皮温皮色可，肌力正常，活动可；双侧股动脉、腘动脉、足背动脉搏动减弱；左侧踝肱指数(ABI )为0.93、右... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"胃肠外科"
]
} | [
{
"rubric_detail": "诊断结论中未明确指出患者患有近肾腹主动脉闭塞症",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": -10
},
{
"rubric_detail": "明确给出慢性肠系膜缺血诊断",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 5
},
{
"rubric_detail": "明确给出下肢动脉粥样硬化性闭塞症诊断",
"rubric_number"... | |
f6d9a7e6-6d20-4f89-9937-1c9ba7836e73 | 9,287 | cn | 李女士，32岁，因“停经9周，超声未见胎心”前来就诊。病史回顾显示，她近3年内共有3次自然流产史：第1次为孕6周的生化妊娠，第2次为孕9周的空孕囊，本次为第3次。她非常焦虑，希望进行全面的检查以明确原因。问题：根据2025年复发性流产病因分级筛查临床实践中国专家共识，李女士的情况是否可诊断为“复发性流产（RSA）”？请阐述诊断标准及其背后的临床考量。假设你计划为李女士启动病因筛查，请基于病因分级筛查的理念，列出应首先进行的一级筛查可能包含的主要方面（至少四个方面），并简要说明理由。 | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"妇产科学"
]
} | [
{
"rubric_detail": "明确判定李女士的情况符合复发性流产（RSA）的诊断标准。",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 8
},
{
"rubric_detail": "模型未正确定义复发性流产（RSA），或未指出其包含生化妊娠、发生在妊娠28周前等关键要素。",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": -5
},
{
"rubric_detail": "导致生化... | |
d97af248-9a73-4a5b-8e9b-a406004cb5b2 | 9,309 | cn | 我在使用HEK-293T细胞样本对目标蛋白Nrf2(约100 kDa)进行WB检测时，多次实验发现经常会出现无信号或信号极弱的情况。而同一块胶上的内参蛋白β-actin（约42 kDa）条带清晰可见。已知我采用的是1.5 mm厚的15孔7.5%浓度的SDS-PAGE胶，NC膜，湿转法100V恒压转膜100分钟，5%脱脂奶粉室温封闭一小时，一抗1：1000四度摇床孵育过夜，采用一抗对应种属的HRP二抗，室温孵育一小时，并使用化学发光法成像。在不更换细胞系种类、SDS-PAGE胶、电泳、转膜、封闭条件及一抗及其孵育条件的情况下，请分析Nrf2无信号/信号弱的可能原因，并给出相应的实验方案建议。 | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"基础医学",
"分子生物学"
]
} | [
{
"rubric_detail": "模型多次复述了用户输入中已提供的实验条件参数，导致内容冗余。",
"rubric_number": 1,
"rubric_tag": "行文结构和格式",
"rubric_weight": -5
},
{
"rubric_detail": "排版混乱，缺乏清晰的小标题或列表结构，导致阅读困难",
"rubric_number": 2,
"rubric_tag": "行文结构和格式",
"rubric_weight": -5
},
{
"rubric_detail": "模型应指出Nrf2蛋白具有半衰... | |
d99d37b8-14d6-4df3-ada7-f5b3721747cb | 9,462 | cn | 一名52岁女性患者，因“发热、关节痛伴皮疹2周，加重3天”入院，患者2周前无明显诱因出现发热，体温波动在38.5-39.8℃，伴有双手腕、膝关节对称性肿痛，同时面颊部出现无明显瘙痒的红色皮疹，日晒后加重，近3天出现活动后气短和夜间不能平卧，患者自述有反复口腔溃疡史但未就医，既往有高血压病史5年服用氨氯地平控制可，无明确肾脏病或肝炎病史，入院查体T 39.1℃，BP 145/90mmHg，神清，面部蝶形红斑，双肺底可闻及细湿啰音，心界向左下扩大，心尖区闻及2/6级收缩期杂音，腹部无压痛，双下肢中度凹陷性水肿，辅助检查示血常规WBC 3.2×10⁹/L，Hb 82g/L，PLT 85×10⁹/L，尿常规示蛋白（+++），颗粒管型5-8... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"医学检验"
]
} | [
{
"rubric_detail": "明确指出患者最可能的初步诊断为系统性红斑狼疮（SLE）",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "诊断依据中提及了蝶形红斑、光过敏或口腔溃疡等具体的皮肤黏膜症状",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 5
},
{
"rubric_detail": "鉴别诊断的疾病列表中包含感染性心内膜炎... | |
f0597e81-d2ba-4069-a6de-8f86d29964e4 | 9,582 | cn | 患者，男，46岁。因“发热、进行性呼吸困难伴干咳2周，加重2天”由急诊收入ICU。患者于18个月前因急性髓系白血病（AML）接受了异基因造血干细胞移植（allo-HSCT）。入室查体：T 38.4°C，P 118次/分，R 28次/分，BP 105/65 mmHg。神志清楚，精神萎靡，胸部听诊双肺呼吸音减弱，未闻及明显干湿啰音，可见皮肤硬化表现及口腔溃疡。血气分析（鼻导管吸氧5L/min）：pH 7.42，PaO2 62 mmHg，PaCO2 32 mmHg。床旁胸片显示双肺透亮度增加，未见明显渗出影。
急诊初步拟诊“重症肺炎、I型呼吸衰竭”，并给予经验性广谱抗生素及抗真菌治疗。完善进一步检查：胸部高分辨率CT（HRCT）示双肺弥漫... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"呼吸内科"
]
} | [
{
"rubric_detail": "明确指出患者的核心诊断为异基因造血干细胞移植后慢性移植物抗宿主病（cGVHD）表现出的闭塞性细支气管炎综合征（BOS）",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 8
},
{
"rubric_detail": "根据患者肺功能FEV1数值判定其病情严重程度为重度（Severe）",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"ru... | |
ba4bb671-0fcc-4f6d-bb37-ea12aab8e5d8 | 9,769 | cn | 我取了小鼠脾脏，研磨制成单细胞悬液，我想用于流式染色检测调节性T细胞的活化，我使用的染色方案是：CD3，CD8，Foxp3，CD44，流式染色发现调节性T细胞的比例为0.05%，请帮我分析原因，并帮我设计完整的调节性T细胞染色方案：包含流式染色的实验步骤和染色使用的抗体方案 | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"基础医学",
"免疫学"
]
} | [
{
"rubric_detail": "指出流式细胞术结果中调节性T细胞比例过低可能源于圈门策略设置不当",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": 5
},
{
"rubric_detail": "分析认为Foxp3抗体失活或荧光基团淬灭是导致检测比例异常的潜在原因",
"rubric_number": 2,
"rubric_tag": "观点分析",
"rubric_weight": 7
},
{
"rubric_detail": "明确指出Foxp3蛋白属... | |
12ec26fa-84c0-4639-b5c5-9e00c62dca0c | 9,854 | cn | 主诉：发现血糖升高20余年，纳差4天
患者20余年前体检发现空腹血糖10mmol/L，无多饮、多食、多尿、无体重减轻，就诊于我院门诊，考虑“糖尿病”，后规律口服阿卡波糖100mgTID、格华止500mgTID、瑞格列奈1mgTID降糖治疗，监测血糖餐前5～7mmol/L，餐后9-11mmol/L。9个月前无明显诱因出现四肢肢体末端麻木感，双足肿胀感，自测空腹血糖8～10mmol/L，餐后11-13mmol/L，未调整降糖方案。2个月前测空腹血糖10.9mmol/L，餐后血糖12.5mmol/L，复查糖化血红蛋白7.9%，尿糖 2+，尿酮体 -，血糖控制欠佳于门诊调整为恩格列净10mgQD、吡格列酮30mgQD、拜唐苹50mgTID... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"内分泌与代谢病"
]
} | [
{
"rubric_detail": "诊断结论中明确包含2型糖尿病、糖尿病酮症酸中毒（DKA）",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "诊断结论中包含糖尿病周围神经病变",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 8
},
{
"rubric_detail": "诊断结论中包含糖尿病肾病（或早期糖尿病肾病）",
"rub... | |
8eb9fe93-8198-491c-a0ae-2d59b62b635a | 9,890 | cn | 患者基本情况
患者：45岁，男性。BMI 16.5 kg/m²（重度营养不良），神志模糊（GCS 13分），血压 85/50 mmHg（多巴胺维持中）。
核心诊断：
重症肺结核（III型 危重症型）：双肺广泛空洞破坏，合并脓毒性休克。
重度急性呼吸窘迫综合征（ARDS）：PaO₂/FiO₂ = 95 mmHg，目前气管插管机械通气中。
药物性肝损伤（DILI）高风险：既往有长期饮酒史，入院查 ALT 125 U/L（3倍正常值上限），总胆红素 38 μmol/L。
疑似侵袭性肺曲霉病：痰培养提示曲霉菌属阳性，G试验阳性。
当前用药（外院带入）：利福平 0.45g QD（鼻饲）、异烟肼 0.3g QD（鼻饲）、吡嗪酰胺 1.5... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"呼吸内科"
]
} | [
{
"rubric_detail": "未建议立即停用异烟肼、利福平和吡嗪酰胺这三种一线抗结核药物",
"rubric_number": 1,
"rubric_tag": "观点分析",
"rubric_weight": -8
},
{
"rubric_detail": "指出停用异烟肼、利福平和吡嗪酰胺这三种一线抗结核药物的原因包括患者ALT已达到正常值上限的3倍，符合肝损伤停药标准",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 7
},
{
"rubric_d... | |
ce8ed8a0-8312-4464-ac08-cd33095eb019 | 9,921 | cn | 患者为59岁男性，确诊右肺神经内分泌癌并脑转移1年余，既往一线治疗予“阿得贝利单抗联合EP方案”治疗后行“阿得贝利单抗联合依托泊苷”维持治疗，维持治疗期间行脑部转移病灶放疗，随后患者因出现肝脏新发转移病灶来诊，后续入组临床药物研究，给予“QLC5508+QL1706+卡铂”方案治疗一周期，用药后一周，此次来院门诊行相关检查结果提示(异常值)：血常规 白细胞计数0.67×10∧9/L，血小板计数14×10∧9/L，PCT 1.17ng/ml，粪便常规提示潜血阳性，凝血六项结果提示血浆纤维蛋白原6.86g/L，血浆D-二聚体3.32mg/L，纤维蛋白降解产物（FDP）11.24 ug/ml，CRP 250.18mg/L，尿常规提示尿潜血... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"肿瘤学"
]
} | [
{
"rubric_detail": "初步诊断明确指出了IV度骨髓抑制，具体包含白细胞、中性粒细胞及血小板的抑制",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 10
},
{
"rubric_detail": "初步明确诊断肝功能异常",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 3
},
{
"rubric_detail": "诊断结论中涵盖了肺神经内分泌癌伴脑转移及肝转移的基础病情"... | |
2008063e-3dd5-4b76-831f-f06ef4e7d739 | 9,952 | cn | 患者基本情况：51岁，绝经前女性，无肿瘤家族史。ECOG评分0分。
核心诊断：左乳三阴性乳腺癌（cT3N1M0，IIIA期）。空心针穿刺活检病理：浸润性导管癌，非特殊类型。免疫组化：ER（-），PR（-），HER2（0）。Ki-67指数：70%。
关键生物标志物：
PD-L1检测：肿瘤浸润免疫细胞阳性（≥1%）。
BRCA1/2基因检测：未发现致病性胚系突变。
治疗经过：新辅助治疗：接受8周期“白蛋白紫杉醇+卡铂+帕博利珠单抗”方案治疗。治疗期间出现2级周围神经病变及1级免疫相关性甲状腺功能减退（已补充左甲状腺素控制良好）。
手术治疗：完成新辅助治疗后行“左乳癌改良根治术+腋窝淋巴结清扫术”。
术后病理：乳腺原发灶内未见残留浸润性癌... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"医疗健康",
"临床医学",
"肿瘤学"
]
} | [
{
"rubric_detail": "明确指出由于患者达到pCR，术后无需追加辅助化疗",
"rubric_number": 1,
"rubric_tag": "事实信息",
"rubric_weight": 8
},
{
"rubric_detail": "建议术后继续使用帕博利珠单抗进行辅助治疗满1年",
"rubric_number": 2,
"rubric_tag": "事实信息",
"rubric_weight": 8
},
{
"rubric_detail": "依据患者初始分期cT3N1判定即使达到pCR仍需进行放疗",
... | |
1dbd3e38-1c81-4cf1-94eb-d1d24f9a2d49 | 10,181 | global | A high-speed stamping production line at an automotive parts factory uses a PROFINET industrial communication system. The main equipment includes: one Siemens S7-1500 controller; eight KUKA robots (controlling die open/close and part handling); and four Keyence vision inspection cameras (real-time measurement of stampe... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "Accurately identify that the protocol issue is operation in Real Time (RT) rather than the more interference-resilient Isochronous Real Time (IRT), resulting in data errors and retransmissions.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 10
},
... | |
6c34d48e-cc4e-4193-be63-a1094f541fe8 | 10,298 | global | In order to tap into new business growth areas, a provincial operator plans to carry out a trial deployment of Rel-18 5G-Advanced NR-DC technology in the live network. This trial will use the FR2 high-frequency band as the primary coverage band, with the core objective of fully supporting MR-DC scenarios. In combinatio... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "The model enumerates the Early TA acquisition methods as primarily UE autonomous measurement, with PDCCH order–triggered RACH procedure as a fallback.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 5
},
{
"rubric_detail": "The model analyzes t... | |
2b4583f1-f332-43c6-999e-9166e6d2c6e5 | 10,308 | global | Title: Review the Fatal Bug in This LLaMA W8A8 Quantized Operator
Problem Description:
I am an architect responsible for inference engine optimization. Recently, in order to run LLaMA-7B on an edge device (NVIDIA Orin), I asked an intern to hand-write a custom W8A8 (INT8 weights, INT8 activations) matrix multiplicatio... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Machine Learning",
"Machine Learning"
]
} | [
{
"rubric_detail": "The answer should compute an arithmetic intensity of approximately 1 Op/Byte (or 2 Ops / 2 Bytes), or explicitly state that the kernel falls into the memory-bound region of the Roofline model and is limited by global memory bandwidth.",
"rubric_number": 1,
"rubric_tag": "Analytical R... | |
364cfadc-3764-4ffd-a2c2-2688ae800950 | 10,447 | global | I am a data development engineer and have recently been responsible for maintaining a user data pipeline. In this pipeline, user registration data is written to MongoDB (the `users` collection). The `created_at` field is provided by the frontend in the format "2026-01-06 10:30:00" (without any timezone information), an... | {
"time_sensitivity": {
"day": "6",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "2026-01"
},
"topics": [
"Industry",
"Databases and Data Engineering",
"Databases and Data Engineering"
]
} | [
{
"rubric_detail": "The report explicitly states that the number of soft-deleted users is 23.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 7
},
{
"rubric_detail": "Based on MongoDB’s total user count of 1,302, the answer correctly calculates that approximately ... | |
deabcd1e-64ae-4659-82ac-646b517cdfc2 | 10,631 | global | Given a non-empty integer array `nums`, where each element can be any integer, and the array may contain one or multiple elements, fully decompose and regroup every digit of every number in the array, and concatenate them to form the smallest possible integer, subject to all the following rules:
[1] Every digit of eve... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Backend Development",
"Backend Development"
]
} | [
{
"rubric_detail": "The code section uses line-level comments (# comments), violating the requirement that only paragraph comments are allowed.",
"rubric_number": 1,
"rubric_tag": "Structure and Formatting",
"rubric_weight": -10
},
{
"rubric_detail": "The answer is organized in the order of:... | |
c68fc03a-3fdc-4cca-824f-f14db3730027 | 10,704 | global | I am a graduate student in the Department of Road and Bridge Engineering, currently participating in professional practice to design a concrete mix proportion for a project. While learning concrete mix design methods, my supervisor explained the specific surface area method. However, preliminary tests indicated issues ... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Civil Engineering",
"Civil Engineering"
]
} | [
{
"rubric_detail": "The answer explicitly identifies the specific surface area values of modern cement and explains that cement fineness has changed, increasing from less than 300 m²/kg in the past to the current 330~350 m²/kg (for 42.5 cement) or exceeding 380 m²/kg (for 52.5 cement).",
"rubric_number": 1,... | |
0d785b81-fc88-438c-964b-e4c8256f9f42 | 10,724 | global | I am a graduate student at Beijing Institute of Technology. My current research focuses on solid electrolytes for sodium-ion batteries, mainly the sodium superionic solid electrolyte NZSP. The core issues to address are low ionic conductivity and the wettability between the electrolyte and the metal electrode. I intend... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Chemical Engineering and Materials",
"Chemical Engineering and Materials"
]
} | [
{
"rubric_detail": "Both NZSP and NHSP electrolytes belong to the NASICON-type (sodium superionic conductor) crystal structure.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 8
},
{
"rubric_detail": "The microstructure of NZSP consists of PO4/SiO4 tetrahedra and ... | |
8276aec4-036f-459b-8770-2f15f693edd2 | 10,767 | global | Graph Neural Networks (GNNs) are a class of machine learning methods that take graph structure into account. One of the most classic algorithms is the Graph Convolutional Network (GCN). This GitHub repository (https://github.com/iDC-NEU/iDC-MlSys_interview) contains an unoptimized GCN implementation written in C++. I a... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Machine Learning",
"Machine Learning"
]
} | [
{
"rubric_detail": "The model suggests converting the graph storage structure from an adjacency list or adjacency matrix to CSR (Compressed Sparse Row) or CSC format.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 4
},
{
"rubric_detail": "The model analyzes two b... | |
d6357459-83e7-4bb6-8cbd-d2ff97c46a2f | 10,838 | global | For a residential project in Sichuan Province, the above-ground portion consists of Class II high-rise residential buildings, and the basement is a single underground level, with the first basement level (B1) serving as a motor-vehicle garage and equipment rooms. Where the basement motor-vehicle garage is divided into ... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Industry",
"Architectural Design",
"Architectural Design"
]
} | [
{
"rubric_detail": "Cite Item 4 of Article 7.1.1 of the \"Points for Technical Review of Fire Protection Design of Housing Construction Projects in Sichuan Province\" (2025 Edition) as the primary basis:\n\"The area of each charging vehicle fire unit in the basement shall not exceed 1000 m². Each fire unit shal... | |
44b07f0a-d6c2-4b74-bfdd-2c7b5a87e1c7 | 10,854 | global | Assume you are a researcher working on agricultural robotics and are designing a robotic manipulator capable of operating efficiently in greenhouse tomato pollination and harvesting tasks. However, you encounter difficulties during path planning for the manipulator:
1. Joint-space planning methods (such as RRT, RRT*, ... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Systems / Embedded / 3D Rendering",
"Systems / Embedded / 3D Rendering"
]
} | [
{
"rubric_detail": "Explicitly proposes a Relaxed-IK inverse kinematics strategy.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 6
},
{
"rubric_detail": "The proposal clearly distinguishes task targets (e.g., tomato fruits, flowers) from environmental obstacles (... | |
ee809a60-d4e2-4514-a3b5-175eb591f21e | 10,904 | global | ```js
const logs = [];
const log = (msg) => logs.push(msg);
const buffer = new Proxy(
{ val: 0 },
{
set(target, prop, value) {
log(`B:Set:${value}`);
target[prop] = value;
return true;
},
}
);
const scheduler = {
then: (resolve) => {
log("Sched:Then");
Promise.resolve().then(... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Frontend Development",
"Frontend Development"
]
} | [
{
"rubric_detail": "Correctly identifies that the object being awaited (`scheduler`) is not a native Promise but a Thenable object, and that its `then` method invocation is wrapped into a microtask rather than being executed synchronously.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
... | |
fd1f36d1-c29a-4077-91f4-b0d23cb38f5b | 10,915 | global | The binary-to-ternary switching of organic electrochemical transistors has always been a relatively complex engineering task. Studies have found that this switching can also be achieved by using near-infrared light. Please elaborate in detail how near-infrared light can be utilized, via the light–ion–electron coupling ... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Semiconductors",
"Semiconductors"
]
} | [
{
"rubric_detail": "The stage of cooperative doping by ions and photogenerated holes involves the migration of I− ions dissolved in the electrolyte into the polymer channel.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 10
},
{
"rubric_detail": "The increase of ... | |
fad912f4-b576-4cd0-b659-9530ee97ade2 | 10,919 | global | There is a modeling process for a mechanical part as follows:
I. Process of generating volume
Create an isosceles trapezoid, referred to as the initial trapezoid.
Its lower base has a length of 90mm, and its upper base has a length of 30mm. Each leg forms an angle of 45 degrees with the lower base. Extrude this trapezo... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Machinery and Automation",
"Machinery and Automation"
]
} | [
{
"rubric_detail": "The theoretical volume of the final finished part obtained by the model is 132684.424mm³ (a very small error is allowed, but the result must be close to the reference value).",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 10
},
{
"rubric_deta... | |
54246069-1446-41a1-8d17-89a0e5c52dc0 | 11,071 | global | I am conducting research on dissimilar metal resistance spot welding (RSW), utilizing aluminum alloy and low alloy steel as the study materials. The objective is to investigate the evolution of internal mechanisms and the nugget formation process during resistance spot welding. The experimental conditions are as follow... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Materials",
"Materials"
]
} | [
{
"rubric_detail": "During the initial stage of welding, the region of high current density on the low alloy steel side shifts from the electrode-to-steel contact edge to the center of the steel sheet.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 10
},
{
"rubr... | |
f0bc2660-fdb2-4e05-9766-e8db285d52e2 | 11,913 | global | In Chengdu, the ground floor of a detached residence features a south-facing open courtyard measuring 4 square meters (2 m × 2 m) adjacent to the living room. The owner plans to enclose this space to convert it into a sunroom with basic natural ventilation; all requisite planning permissions and property management app... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Strongly time-sensitive",
"year_month": "NA"
},
"topics": [
"Industry",
"Architectural Design",
"Architectural Design"
]
} | [
{
"rubric_detail": "The response cites specific climatic parameters for the Chengdu region, such as annual average sunshine duration of 1,000–1,400 hours or an annual average humidity exceeding 70%.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 8
},
{
"rubric_de... | |
58a83321-05c2-4d66-86d0-1fbca0dc4741 | 11,917 | global | An existing residential unit in Shanghai is located on the 5th floor. A square exterior window is set on its south façade, with a clear area of 2.0 m² (window width approximately 1.41 m, height approximately 1.41 m). The window sill height is 0.6 m above the interior finished floor level. The room exhibits a pronounced... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Architectural Design",
"Architectural design"
]
} | [
{
"rubric_detail": "The answer explicitly identifies Shanghai as belonging to the hot-summer/cold-winter climate zone and provides corresponding parameters: summer daily peak solar radiation can reach 800–900 W/m².",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 8
},
... | |
5e785915-8448-461e-b663-9a8c9c777c4b | 11,975 | global | Sodium metal batteries are currently a hot research topic, and studies have found that the mixed-solvation electrolyte strategy may be beneficial for improving the performance of sodium metal batteries. Please answer:
1. What is the core design concept of mixed-solvation electrolytes, and explain the respective roles a... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Chemical Engineering and Materials",
"Chemical Engineering and Materials"
]
} | [
{
"rubric_detail": "The core design concept of mixed-solvation electrolytes for sodium batteries is clearly defined as achieving a balance between bulk-phase ion transport and electrode interfacial stability through the rational ratio of strong and weak solvents.",
"rubric_number": 1,
"rubric_tag": "Fac... | |
89055e11-d0a5-4e7b-8d15-e1002f4cae54 | 1,238 | global | Background: You are a physical-layer systems engineer at a leading telecommunications equipment manufacturer. You are responsible for optimizing a 5G macro-cell gNB deployment in an Urban Dense area. The environment features high-rise buildings, uneven user distribution, and extensive reflections and blockages—i.e., a ... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "Signaling details for dynamic-TDD CLI coordination: the answer must accurately state which DCI format (e.g., DCI 2_0) carries the Slot Format Indicator (SFI), and explicitly note that SFI configures Flexible symbols at symbol-level granularity.",
"rubric_number": 1,
"rubric_tag": "An... | |
71f76252-1db0-41f8-93bf-338a89f17341 | 1,246 | global | You are a wireless network optimization expert. On February 3rd, in the Hospital South Gate Building 1, Cell -2, the 'no call drop' voice call proportion is 97.6%, which is abnormal; the 'smooth playback' short video service proportion is 97.17%, which is abnormal. The KPI status is as follows:
1) Number of 5G call dro... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Weakly time-sensitive",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "Capacity issue analysis: PRB utilization exceeding reasonable thresholds leads to resource congestion, scheduling delay, and packet loss.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 8
},
{
"rubric_detail": "Interference control optimizatio... | |
6b4ea30a-e9f1-4a30-a3bc-c6c006354ade | 1,378 | global | You are responsible for urban 5G NSA network optimization at a provincial capital carrier's network optimization center. Business District A is a local high-end commercial area which has received a large volume of user complaints over three consecutive months stating that "the phone displays 5G, but the network speed i... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "The model analyzes the problem from three dimensions: \"Coverage/Interference\", \"Capacity/Bearer\", and \"NSA Parameters/Multi-RAT Coordination\".",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 4
},
{
"rubric_detail": "Explicitly points out... | |
6129a42f-a16c-4a28-8912-c60332e70406 | 1,381 | global | An operator requires the deployment of a 5G SA network in an urban area. Recently, a surge of user complaints was received from a high-end commercial building (8 floors total: 2 underground levels for parking and equipment rooms, 6 above-ground levels for retail, dining, and office areas; total gross floor area approxi... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "Accurately identify the three core causes of weak signals on the first basement level (high-frequency penetration loss, insufficient picocell coverage, and metal shielding/blockage in the building).",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 6
... | |
9c2672f2-430f-44cc-823b-2784f3a84a2b | 1,394 | global | You are a senior expert in a metropolitan metro communication network. Recently, Metro Line 2, Line 4, and the control centers of both lines have reported composite communication faults. The phenomena are complex and interrelated, posing a potential risk to operational safety. The faults are concentrated during morning... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "Propose a unified root-cause hypothesis: recent independent municipal pipe jacking construction at two locations has caused physical micro-damage to metro optical cables, with vibration-sensitive and temperature/load-sensitive characteristics. During business peak periods, this damage is cas... | |
d6344516-e4f6-42b3-a2a6-f1329ed16dbf | 161 | global | The transfer of plasmon-generated hot carriers in metal/semiconductor heterojunctions has long faced severe energy dissipation. Recent studies have identified an ultrafast non-thermalized electron transfer pathway at the Au/GaN interface. Please address the following: 1. What is ultrafast non-thermalized electron trans... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Semiconductors",
"Semiconductors"
]
} | [
{
"rubric_detail": "Definition of non-thermalized electron transfer: An ultrafast process wherein electrons are injected directly into the semiconductor without undergoing prior thermalization.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 10
},
{
"rubric_detai... | |
dcc3dbb7-0cbb-4f75-ae06-0efbb8987ad0 | 1,650 | global | In an urban HetNet hotspot environment (e.g., a commercial district) utilizing an LTE Band 7 (2.6 GHz) macro cell as the anchor (MCG) and a dense overlay of NR Band n78 (3.5 GHz) small cells as the Secondary Cell Group (SCG), the network faces severe downlink interference. Specifically, at the NR cell edge, low RSRP/RS... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "Proposes that simultaneous UL transmissions on LTE Band 7 and NR n78 may cause out-of-band emissions exceeding limits due to harmonics or intermodulation products, and explains corresponding UE-side interference management mechanisms such as A-MPR (Additional Maximum Power Reduction).",
... | |
54a18a27-264b-42c7-9762-c030dc97bfe1 | 1,678 | global | Design a 1-to-8 unequal power divider with the following requirements: Operating frequency: 9.3–9.5 GHz. The theoretical distribution (split) losses from Output Port 1 to Output Port 8 are -5.4 dB, -6.0 dB, -7.1 dB, -8.8 dB, -11.3 dB, -14.6 dB, -18.8 dB, and -22.7 dB, respectively. For each branch, the insertion loss e... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "For the preferred scheme, the selected implementation is a low-loss suspended microstripline approach.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 10
},
{
"rubric_detail": "Either the preferred or the alternative scheme adopts a substrate ... | |
36d1050a-72a1-4210-94c8-cd654bc25132 | 1,749 | global | Technological Breakthrough in Blind Adaptive Processing of LFM Radar Signals in Complex Electromagnetic Environments
I. Project Background and Challenges
You are developing a new generation long-range surveillance radar system. Its core mission is to achieve reliable detection and tracking of high-dynamic, low-observa... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "The answer points out that the power spectral density of the local oscillator phase noise at 1kHz offset is -80 dBc/Hz.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 6
},
{
"rubric_detail": "The answer calculates the integrated phase noise po... | |
6267d153-72b8-45ef-81a5-d88db387096c | 1,750 | global | Analyze the 4G/5G NSA network quality in a large mixed-use commercial complex in the city center. The complex includes a shopping mall, cinema, dining, a live streaming base, and office buildings. Complaints are concentrated during weekend evening peak hours (19:00–22:00): users report that during short video live stre... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "Explicitly state that 1080p live streaming requires an uplink rate of approximately ≥4 Mbps with relative stability, and use this to explain why the current network experience is inevitably unstable.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 9
... | |
d46c9edd-b2e7-41f0-83a9-faf219653650 | 1,924 | global | You are an electrical engineer responsible for upgrading an intelligent warehouse management system. You are currently designing the charging module and charging strategy for electric forklifts in an automotive parts factory.
Current factory status:
(1) There are 24 electric forklifts, all using 48 V / 400 Ah lithium ... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "The answer explicitly states the energy of the 48 V / 400 Ah battery and converts it to kWh; the value falls within a reasonable range of 18–20 kWh (e.g., “about 19 kWh”), with units.",
"rubric_number": 1,
"rubric_tag": "Instructions Following",
"rubric_weight": 2
},
{
"r... | |
b0cc7823-86a6-4a3e-acdd-0d20af89806e | 4,039 | global | You are an expert in machine learning, and your current research focuses on underwater image enhancement. You have designed an encoder–decoder architecture and trained the model using Mean Squared Error (MSE) as the loss function. During training, you observe that the MSE on the training set steadily decreases, and the... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Machine Learning",
"Machine Learning"
]
} | [
{
"rubric_detail": "Provide an in-depth analysis of the model and clearly point out the fundamental tendency of the MSE loss to drive the network toward predicting the conditional mean of all possible solutions (i.e., the mean solution).",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"r... | |
bba510cb-38c5-4c70-88e3-14780a0491c6 | 4,164 | global | I am the owner of a recommendation system at an internet company. My team is responsible for a large-scale recommender system, whose core model is a deep-learning-based CTR prediction model used to rank items in the home feed.
In the first quarter of 2025, we upgraded the model from the legacy Model A to Model B. Mode... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Machine Learning",
"Machine Learning"
]
} | [
{
"rubric_detail": "The answer states that it is not possible to directly conclude that Model B is worse than Model A.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 5
},
{
"rubric_detail": "The analysis points out that the 0.3% request failure rate is not rando... | |
f0bfdae8-df07-4c23-8ac0-08abcd0329be | 5,166 | global | Scenario Description:
You are a recommendation algorithm architect at a large e-commerce platform (similar to Taobao or Amazon). The team is refactoring the recall layer (Match Stage) of the "You May Also Like" system, with the goal of efficiently retrieving a Top-1000 candidate set of items that a user may be interest... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Machine Learning",
"Machine Learning"
]
} | [
{
"rubric_detail": "Clearly points out that the inflated AUC of 0.99 is caused by overly simple negative samples (easy negatives), such that the model only learns coarse-grained category-level distinctions.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 10
},
{
... | |
0defb49c-e4f5-451b-9821-807d77e8c8b3 | 5,430 | global | The communication base station RRU (Remote Radio Unit) is deployed in the South China region. During the summer period from June to August, the RRU occasionally experiences disconnection from the DU (Distributed Unit). Analysis of the log files uploaded by the RRU and DU reveals that the specific alarm is caused by the... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "The analytical framework encompasses the investigation of meteorological conditions, such as temperature differentials, rainfall, humidity, or thunderstorms.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 10
},
{
"rubric_detail": "Advises ver... | |
591d5f51-ed05-4c50-8abd-7a79c1333497 | 5,545 | global | Following the launch of Huawei Mate60, user-equipment (UE) capabilities have increased substantially compared with three years ago. As a result, the UE capability field featureSet ID may exceed 32, crossing an assumed boundary and triggering failures in Task No. 67. The main controller board then repeatedly reboots; th... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "The response cites relevant content from 3GPP specifications regarding the definition of UE Capability or the FeatureSet ID range (e.g., TS 38.331).",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 6
},
{
"rubric_detail": "The model points out ... | |
64b0f439-36d8-4fa1-8e81-81d37447cccf | 5,768 | global | A government–enterprise leased line customer reports that their 1000M bandwidth service delivered over GPON experiences severe web page response latency and frequent video conferencing freezes every day between 14:00 and 16:00. However, when a single-thread Speedtest is performed, the downstream rate exceeds 900 Mbps.
... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "Qualitative analysis of optical power critical points:\nThe fault analysis explicitly points out that the ONU receive optical power of -24.5dBm is close to the sensitivity threshold of the optical module.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight":... | |
550f71ad-94fe-40a0-9688-6acad415e987 | 8,614 | global | 【Task Background】
Our company is attempting to pilot a semantic-based low-altitude video downlink/telemetry system within the 5G-Advanced live network (5G-A). This system abandons traditional H.265 encoding/codec in favor of 'Deep Joint Source-Channel Coding (Deep JSCC)' technology. By utilizing an edge-side teacher mo... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "Identify Objective Misalignment in the Loss Function: Point out that JSCC targeting MSE/PSNR will smooth out high-frequency obstacle boundaries.",
"rubric_number": 1,
"rubric_tag": "Analytical Reasoning",
"rubric_weight": 8
},
{
"rubric_detail": "Propose 'Semantic-Native ... | |
302703db-b1c9-43e1-9684-c524139d6545 | 9,591 | global | During R&D, performance verification revealed that the uplink sensitivity was 1–2 dB worse than the 3GPP requirement. Upon environmental inspection, it was confirmed that all device connections were secure, and there were no adjacent-band carrier emissions from nearby RRUs. Please analyze potential causes and provide c... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "The response identifies specific hardware causes for insufficient receive chain (RX chain) gain, including low gain in the Low Noise Amplifier (LNA) or excessive insertion loss in the filter.",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 10
},
{
... | |
025bf5b1-99d0-4d08-872e-5c4c7a77c5dd | 9,682 | global | You are a backend engineer for an e-commerce application. When a user opens a product detail page, the system invokes a core API to return the aggregated data for that page. This aggregation is assembled from four categories of information. The first category is the product’s base information, such as title, images, an... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Backend Development",
"Backend Development"
]
} | [
{
"rubric_detail": "Explicitly identifies that the first key reason for the low hit rate is the user-dimension cache-key design, which leads to low reuse and a cardinality explosion. The analysis mentions the region–product–user cache-key design and ties it to the provided data (180 million keys; tens of thousa... | |
e2487a94-a128-4b67-9ed9-3fb056e28d5b | 9,705 | global | An intelligent production line of an automotive parts manufacturing enterprise adopts a Siemens S7-1500 PLC as the main controller, and connects 28 distributed I/O modules (ET 200SP), 12 servo drives (Sinamics V90 PN), 8 barcode scanners (with Profinet interface), and 4 industrial robots (KUKA KR C4, Profinet device) v... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "When analyzing the causes of Profinet communication timeouts, it is necessary to clearly point out that “unshielded cables laid in the same tray as power cables” leading to electromagnetic interference is the primary core cause, and to explain the mechanism by which this induces CRC errors a... | |
1fb6bbf5-394d-49c7-ae64-bc374b0fcc3b | 9,706 | global | A battery assembly workshop adopts an architecture comprising PLC controller + industrial robot + distributed Input/Output (IO) modules. The core communication utilizes the Profinet IO Industrial Ethernet protocol (including an IRT real-time communication channel with priority level 3), establishing a ring network topo... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "The model accurately identifies the causes of Profinet latency (Electromagnetic coupling interference + IRT bandwidth/priority configuration defects + Ring network synchronization jitter).",
"rubric_number": 1,
"rubric_tag": "Factual Information",
"rubric_weight": 10
},
{
... | |
56cc66ac-2bde-4ce0-9c9e-8c816026020c | 9,804 | global | In an intelligent-manufacturing line-upgrade project for the body-in-white welding shop of a joint-venture automotive plant, the core welding stations adopt a Profinet IO + industrial Ethernet ring architecture. The system includes an S7-1500 PLC (controller/master), 20 IO-Link slave stations (welding-gun positioning s... | {
"time_sensitivity": {
"day": "NA",
"time_sensitivity": "Time-agnostic",
"year_month": "NA"
},
"topics": [
"Industry",
"Telecommunications",
"Telecommunications"
]
} | [
{
"rubric_detail": "When defining troubleshooting steps, it must explicitly require checking all relevant industrial Ethernet switch port error counters (e.g., CRC, FCS, Alignment Errors) and treat them as key evidence to collect for physical- or link-layer issues.",
"rubric_number": 1,
"rubric_tag": "F... |
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